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Credit Name
Rego, A. Cristina
 
Full Name
Rego, Ana Cristina Carvalho
 
Variants
Rego, Ana Cristina
Rego, A. C.
 
 
 
 
Ciência ID
 
Biography
Ana Cristina Rego (Ph.D.) is Associate Professor at the Faculty of Medicine, University of Coimbra (FMUC), lecturing classes of Biochemistry, Neuroscience and Neurobiology, and is head of the research group ‘Mitochondria and Neurodegenerative Disorders’ (current designation) at the Center for Neuroscience and Cell Biology (CNC), Univ. Coimbra (UC), since 2003. AC Rego initiated as Teaching Assistant in 1997 at FMUC, was Assistant Professor since 1999, and received the Tenure positition in 2004 and the 'Agregação' degree in 2010. AC Rego obtained the Master degree in Cell Biology in 1994 and the Ph.D. in Cell Biology in 1999 at UC, under the supervision of Prof. Catarina R. Oliveira, and was postdoctoral researcher in the Lab of Prof. David G. Nicholls, at the Univ. Dundee, Scotland, UK, and visiting researcher at the Buck Institute, Novato, CA, USA (David Nicholls Lab), from 1998-2000. In 2004-05 AC Rego was the coordinator of the BEB PhD Programme at CNC. The research group coordinated by AC Rego at CNC-UC investigates molecular mechanisms of familial and age-related neurodegenerative disorders, including Huntington’s and Alzheimer’s diseases, focusing on changes in mitochondrial function, dynamics and biogenesis and metabolic deregulation, glutamatergic postsynaptic dysfunction, and related exosomal content. Funding has been garnered by HighQ Foundation (USA), Lundbeck Foundation, ‘Instituto de Investigação Interdisciplinar’ (IIIUC), ‘Fundação para a Ciência e a Tecnologia’ (FCT) and EHDN-European Huntington Disease Network projects, two 1st edition major‘prizes/awards promoted by Santa Casa da Misericórdia de Lisboa’ (SCML) and ‘Fundação Luso Americana para o Desenvolvimento’ (FLAD) , as well as through industry contracts (e.g. TEVA, Sigma-Tau, Mycology Lab). AC Rego holds a H-factor of 44 (i10=98, at Google Scholar) and ~6400 citations, published 117 peer-reviewed articles (92 original publications), 23 book chapters (11 in portuguese) and more than 110 abstracts in research meetings. AC Rego also supervised/co-supervised the work of several post-doctoral fellows and a 'Ciência-FCT' researcher, 18 Ph.D. students and 37 Master students (concluded degrees). AC Rego acts as a reviewer for scientific journals and funding bodies, including Parkinson's UK, Alzheimer’s Research UK, Austrian Science Fund (FWF), Agence Nationale de la Recherche (ANR), Auckland Medical Research Foundation (AMRF), Telethon Fondazione, Israel Science Foundation, Wellcome Trust and Alzheimer’s Association. ACR is member of the ERA-Chair recruitment and monitoring team ERAatUC, at University of Coimbra, member of the board of CNC-UC, Vice-President of the Portuguese Brain Council and President of the Portuguese Society for Neuroscience (SPN).
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Estado
Investigador UC
 

Publications

Results 1-76 of 76 (Search time: 0.002 seconds).

Issue DateTitleAuthor(s)TypeAccess
127-Sep-20182B or not 2B that is the question about the synaptic proteasome in glutamatergic synapsesÁguas, Rodolfo das Neves masterThesisopenAccess
2Feb-2015Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human LymphoblastsNaia, Luana ; Ferreira, I. Luísa ; Cunha-Oliveira, Teresa ; Duarte, Ana I. ; Ribeiro, Márcio ; Rosenstock, Tatiana R. ; Laço, Mário N. ; Ribeiro, Maria J. ; Oliveira, Catarina R. ; Saudou, Frédéric ; Humbert, Sandrine ; Rego, A. Cristina articleopenAccess
32007Adaptation to oxidative stress in the chronic effects of cocaine and amphetamineCunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. articleopenAccess
42000Adenosine A2AReceptors Regulate the Extracellular Accumulation of Excitatory Amino Acids upon Metabolic Dysfunction in Chick Cultured Retinal CellsRego, Ana Cristina ; Agostinho, Paula ; Melo, Joana ; Cunha, Rodrigo A. ; Oliveira, Catarina R. articleopenAccess
5Sep-2016Amyloid-beta peptide-evoked Src signaling and redox changes in hippocampal cellsFão, Lígia Vanessa Rocha masterThesisopenAccess
62001Antioxidant effect of flavonoids after ascorbate/Fe2+-induced oxidative stress in cultured retinal cellsAreias, Filipe Miguel ; Rego, A. Cristina ; Oliveira, Catarina R. ; Seabra, Rosa Maria articleopenAccess
714-Jun-2017Autophagy in Neurodegeneration: Latest developments on eating ourselves out of diseaseFigueiredo, Pedro Xavier Pinto de masterThesisopenAccess
8Feb-2015Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium releaseFerreira, Ildete Luísa ; Ferreiro, Elisabete ; Schmidt, Jeannette ; Cardoso, João M ; Pereira, Cláudia M F ; Carvalho, Ana Luísa ; Oliveira, Catarina R ; Rego, A Cristina articleopenAccess
92013Aβ-mediated changes in CREB and ERK activity in cultured cortical neurons : involvement of NMDA receptorsRosa, Valeria de masterThesisopenAccess
102013Aβ-mediated changes in CREB and ERK activity in cultured cortical neurons: involvement of NMDA receptorsDe Rosa, Valeria masterThesisopenAccess
112009BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neuronsAlmeida, S. ; Laço, M. ; Cunha-Oliveira, T. ; Oliveira, C. R. ; Rego, A. C. articleopenAccess
12Sep-2011Bioenergetic dysfunction in Huntington's disease human cybridsFerreira, I Luisa ; Cunha-Oliveira, Teresa ; Nascimento, Maria V ; Ribeiro, Márcio ; Proença, M Teresa ; Januário, Cristina ; Oliveira, Catarina R ; Rego, A Cristina articleopenAccess
132006Caspase-dependent and -independent cell death induced by 3-nitropropionic acid in rat cortical neuronsAlmeida, Sandra ; Brett, Ana C. ; Góis, Inês N. ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
142009Cell therapy in brain neurodegenerative movement disorders :a clinical perspectiveRibeiro, Ana Cláudia Saraiva masterThesisopenAccess
152008Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugsCunha-Oliveira, Teresa ; Rego, Ana Cristina ; Oliveira, Catarina R. articleopenAccess
162012Changes in transcription factors related to mitochondrial biogenesis and antioxidant defense in alzheimer’s disease modelsCaldeira, Gladys Tarcila Lima masterThesisopenAccess
1710-Feb-2015Characterization of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's diseaseLopes, Carla Maria Nunes doctoralThesisembargoedAccess
182016Characterization of mitochondrial function and dynamics in models of Machado-Joseph diseaseAlmeida, Filipa Luísa Lourenço de masterThesisembargoedAccess
1919-Jul-2018Characterization of the postsynaptic density in a transgenic mouse model of Huntington’s diseasePassos, Diogo André Malheiro masterThesisembargoedAccess
20Feb-2012Consequences of mitochondrial dysfunction in Huntington's Disease and protection via phosphorylation pathwaysCunha-Oliveira, Teresa ; Ferreira, Ildete L ; Rego, A Cristina bookPartopenAccess
212003Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosisGil, Joana ; Almeida, Sandra ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
222005Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxideCunha-Oliveira, T. ; Rego, A. C. ; Morgadinho, M. T. ; Sarmento, A. ; Macedo, T. ; Oliveira, C. R. conferenceObjectopenAccess
232006Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxideCunha-Oliveira, Teresa ; Rego, A. Cristina ; Morgadinho, Maria Teresa ; Macedo, Tice ; Oliveira, Catarina Resende articleopenAccess
24Sep-2012Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in micePereira, Frederico ; Cunha-Oliveira, Teresa ; Viana, Sofia ; Travassos, Ana Sofia ; Nunes, Sara ; Silva, Carlos ; Prediger, Rui ; Rego, Ana Cristina ; Ali, Syed ; Fontes Ribeiro, Carlos Alberto articleclosedAccess
251999Distinct Glycolysis Inhibitors Determine Retinal Cell Sensitivity to Glutamate-Mediated InjuryRego, Ana Cristina ; Areias, Filipe ; Santos, Maria Sancha ; Oliveira, Catarina articleopenAccess
262016Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural CellsLopes, Carla ; Aubert, Sophie ; Bourgois-Rocha, Fany ; Barnat, Monia ; Rego, Ana Cristina ; Déglon, Nicole ; Perrier, Anselme L. ; Humbert, Sandrine articleopenAccess
278-Mar-2012Drugs of abuse induce apoptotic features in PC12 cells.Oliveira, M Teresa ; Rego, A Cristina ; Macedo, Tice R ; Oliveira, Catarina R articleopenAccess
28Jan-2014Dysfunctional synapse in Alzheimer’s disease – a focus on NMDA receptorsMota, Sandra I. ; Ferreira, Ildete L. ; Rego, A. Cristina articleopenAccess
292009Dysregulation of CREB Activation and Histone Acetylation in 3-Nitropropionic Acid-Treated Cortical Neurons: Prevention by BDNF and NGFAlmeida, Sandra ; Cunha-Oliveira, Teresa ; Laço, Mário ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
302016Early mitochondrial modifications in YAC128 transgenic model of Huntington’s diseaseMaranga, Carina Sofia Barradas masterThesisembargoedAccess
319-Mar-2012Efeito crónico da heroína e do peróxido de hidrogénio em células PC12Cunha-Oliveira, Teresa ; Rego, A Cristina ; Morgadinho, M Teresa ; Macedo, Tice R ; Oliveira, Catarina R articleopenAccess
322002Effect of amyloid beta-peptide on permeability transition pore: A comparative studyMoreira, Paula I. ; Santos, Maria S. ; Moreno, António ; Rego, A. Cristina ; Oliveira, Catarina articleopenAccess
331998Effect of Glucose Deprivation and Acute Glutamate Exposure in Cultured Retinal CellsRego, Ana Cristina ; Areias, Filipe Miguel ; Santos, Maria Sancha ; Oliveira, Catarina R. articleopenAccess
342011Excitotoxicidade em células granulares do cerebelo que expressam ataxina-3 mutante - relevância para a patogénese da doença de Machado-JosephSousa, Sofia Isabel Oliveira masterThesisopenAccess
358-Mar-2012Expression of NR1/NR2B N-Methyl-d-Aspartate Receptors Enhances Heroin Toxicity in HEK293 CellsDomingues, António ; Cunha-Oliveira, Teresa ; Laço, Mário LN ; Macedo, Tice ; Oliveira, Catarina R ; Rego, A Cristina articleopenAccess
362004FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical culturesAlmeida, Sandra ; Domingues, António ; Rodrigues, Luís ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
372001Glutamate regulates the viability of retinal cells in cultureRego, A. Cristina ; Santos, Maria Sancha ; Areias, Filipe ; Proença, Teresa ; Oliveira, Catarina R. articleopenAccess
381999Glutamate-mediated inhibition of oxidative phosphorylation in cultured retinal cellsRego, Ana Cristina ; Sancha Santos, Maria ; Oliveira, Catarina Resende articleopenAccess
3915-Nov-2012Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cellsRibeiro, Márcio ; Rosenstock, Tatiana ; Cunha-Oliveira, Teresa ; Ferreira, Ildete ; Oliveira, Catarina R. ; Rego, Ana Cristina articleopenAccess
402005Heroin-induced degeneration of cortical neurons involves mitochondria-dependent apoptosisCunha-Oliveira, T. ; Rego, A.C. ; Macedo, T. ; Oliveira, C.R. articleopenAccess
418-Mar-2017Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's DiseaseNaia, Luana ; Cunha-Oliveira, Teresa ; Rodrigues, Joana ; Rosenstock, Tatiana R ; Oliveira, Ana ; Ribeiro, Márcio ; Carmo, Catarina ; Oliveira-Sousa, Sofia I ; Duarte, Ana I ; Hayden, Michael R ; Rego, A Cristina articleopenAccess
422015Increasesd brain levels of hydrogen peroxide in a transgenic mouse model of Huntington's diseaseLaço, Mário Luís Nôro masterThesisembargoedAccess
4312-Nov-2007Influence of oxidative stress and type 2 diabetes mellitus on neuronal function and metabolism : the neuroprotective role of insulinDuarte, Ana Isabel Marques doctoralThesisopenAccess
4421-Jan-1999Influence of reactive oxygen species and glutamate on the cytotoxicity of cultured retinal cells : a model of neuronal ischaemiaRego, Ana Cristina Carvalho doctoralThesisembargoedAccess
451999Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stressRego, Ana Cristina ; Santos, Maria Sancha ; Oliveira, Catarina R. articleopenAccess
461998Influence of vitamin E succinate on retinal cell survivalRego, Ana Cristina ; Santos, Maria Sancha ; Proença, Maria Teresa ; Oliveira, Catarina R. articleopenAccess
47Sep-2014Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cellsRibeiro, Márcio ; Rosenstock, Tatiana R. ; Oliveira, Ana M. ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
48Oct-2006Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stressDuarte, Ana I. ; Proença, Teresa ; Oliveira, Catarina R. ; Santos, Maria S. ; Rego, A. Cristina articleopenAccess
492012Interplay between Alpha-Synuclein and Oxidative Stress in Parkinson´s Disease Cell ModelsPerfeito, Rita Catarina Gonçalves doctoralThesisopenAccess
502008Mechanisms of neurodegeneration in Huntington's diseaseGil, Joana M. ; Rego, Ana Cristina articleopenAccess
5113-Apr-2007Mechanisms of neurodegeneration in transgenic models of Huntington's diseaseGil, Joana Maria do Amaral Campos doctoralThesisopenAccess
522013Medical Toxicology of Drugs of AbuseCunha-Oliveira, Teresa ; Rego, Ana Cristina ; Carvalho, Félix ; Oliveira, Catarina R. bookPartopenAccess
532003Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal culturesRego, A. Cristina ; Monteiro, Nuno M. ; Silva, Ana P. ; Gil, Joana ; Malva, João O. ; Oliveira, Catarina R. articleopenAccess
542006Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamineCunha-Oliveira, T. ; Rego, A. C. ; Cardoso, S. M. ; Borges, F. ; Swerdlow, R. ; Macedo, T. ; Oliveira, C. R. articleopenAccess
552003Mitochondrial Dysfunction and Reactive Oxygen Species in Excitotoxicity and Apoptosis: Implications for the Pathogenesis of Neurodegenerative DiseasesRego, A. Cristina ; Oliveira, Catarina R. articleopenAccess
567-Jul-2017Mitochondrial function analysis in diabetes and chronic periodontitis-derived human blood cells: role of resistinCosta, Ana Solange Gomes masterThesisembargoedAccess
572011Molecular interaction between cocaine and opioids. Implications on Speedball's toxicityCunha-Oliveira, T. ; Silva, L. ; Silva, A. M. ; Santos, M. S. ; Garrido, J. ; Borges, F. ; Rego, A. C. ; Oliveira, C. R. conferenceObjectopenAccess
585-Apr-2017Neurobiology of the circadian clock: Metabolism control & Implications for Alzheimer´s diseaseSilva, Antonio Manuel Carvalho da doctoralThesisopenAccess
597-Nov-2007Neuronal dysfunction induced by drugs of abuseOliveira, Maria Teresa Martins da Cunha doctoralThesisopenAccess
602012Neurotoxicity of cocaineCunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. bookPartopenAccess
618-Mar-2012Neurotoxicity of heroin-cocaine combinations in rat cortical neuronsCunha-Oliveira, Teresa ; Rego, A Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina R articleopenAccess
6228-Aug-2014Oxidative Stress and Drugs of Abuse: An UpdateCunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. articleopenAccess
639-Jul-2014Oxidative stress in Huntington's disease knock-in striatal cellsRibeiro, Márcio José do Coito doctoralThesisopenAccess
64Jul-2010Peripheral and cerebral metabolic features in an animal model of huntington's disease expressing full-length mutant huntingtinLopes, Carla Maria Nunes masterThesisopenAccess
652012Pyruvate dehydrogenase and mitochondrial function in Huntington’s disease – influence of insulin/IGF and histone deacetylase inhibitorsRodrigues, Joana Cristina P. masterThesisopenAccess
6630-Apr-2009The R6 lines of transgenic mice: A model for screening new therapies for Huntington's diseaseGil, Joana M. ; Rego, A. Cristina articleopenAccess
67Sep-2013Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abusePerfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina articleopenAccess
681-Nov-2012Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abusePerfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina articleopenAccess
69Mar-2013Role of alpha-synuclein in neurodegenerationNoronha, Carolina de Freitas masterThesisopenAccess
7025-Jan-2017Role of lysine deacetylases on transcription regulation and mitochondrial function in Huntington's diseaseNaia, Luana Carvalho doctoralThesisopenAccess
712013Role of selective kinases and GDNF on iron-mediated alpha-synuclein phosphorylation-relevance to Parkinson's diseaseSantos, Paulo André Ribeiro dos masterThesisopenAccess
72Sep-2019Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseasesFão, Lígia ; Mota, Sandra ; Rego, Ana Cristina articleopenAccess
732007Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neuronsCunha-Oliveira, Teresa ; Rego, A. Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina Resende articleopenAccess
74Oct-2006Synthesis and Cytotoxic Profile of 3,4-Methylenedioxymethamphetamine (“Ecstasy”) and Its Metabolites on Undifferentiated PC12 Cells: A Putative Structure−Toxicity RelationshipMilhazes, Nuno ; Cunha-Oliveira, Teresa ; Martins, Pedro ; Garrido, Jorge ; Oliveira, Catarina ; Rego, A. Cristina ; Borges, Fernanda articleopenAccess
752015The role of GHSR1 in dentate gyrus adult neurogenesisDias, Inês Saragoça masterThesisopenAccess
768-Mar-2012Toxic Effects of Opioid and Stimulant Drugs on Undifferentiated PC12 CellsOliveira, M Teresa ; Rego, A Cristina ; Morgadinho, M Teresa ; Macedo, Tice R ; Oliveira, Catarina R articleopenAccess