Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105457
Title: | Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma | Authors: | Geva, Michal Gershoni-Emek, Noga Naia, Luana Ly, Philip Mota, Sandra Rego, Ana Cristina Hayden, Michael R. Levin, Leonard A. |
Issue Date: | 9-Nov-2021 | Publisher: | Springer Nature | Serial title, monograph or event: | Scientific Reports | Volume: | 11 | Issue: | 1 | Abstract: | Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes retinal degeneration. Activation of the S1R exerts neuroprotective effects in models of retinal degeneration. Pridopidine is a highly selective and potent S1R agonist in clinical development. We show that pridopidine exerts neuroprotection of retinal ganglion cells in two different rat models of glaucoma. Pridopidine strongly binds melanin, which is highly expressed in the retina. This feature of pridopidine has implications to its ocular distribution, bioavailability, and effective dose. Mitochondria dysfunction is a key contributor to retinal ganglion cell degeneration. Pridopidine rescues mitochondrial function via activation of the S1R, providing support for the potential mechanism driving its neuroprotective effect in retinal ganglion cells. | URI: | https://hdl.handle.net/10316/105457 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-01077-w | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Neuroprotection-of-retinal-ganglion-cells-by-the-sigma1-receptor-agonist-pridopidine-in-models-of-experimental-glaucomaScientific-Reports.pdf | 9.74 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
8
checked on Oct 7, 2024
WEB OF SCIENCETM
Citations
9
checked on Oct 2, 2024
Page view(s)
89
checked on Oct 8, 2024
Download(s)
50
checked on Oct 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License