Grazina, Manuela
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Name
Grazina, Manuela
Variants
Grazina, M.
Unidade de I&D
Ciência ID
Scopus Author ID
Researcher ID
Status
UC Researcher
Biography
Manuela Grazina is specialized in Human Genetics, Biochemical Genetics and Pharmacogenomics, with a major focus in the study of a group of rare diseases, mitochondrial cytopathies, and neuropsychiatric disorders, particularly drug addiction and pain.
She has got her PhD in Biomedical Sciences in the area of Biochemical Genetics (2006), Graduated in Biomedicine (1997), Master in Cell Biology (specialization in Neurogenetics; 2004) and she has a degree in Biochemistry (5 years grade, pre – Bologna, 1991), at the University of Coimbra.
She is member of CNC as Researcher since 1992, and created the Laboratory of Biochemical Genetics (in CNC / FMUC) in 1995, at the University of Coimbra, with development of biochemical and genetic tests as tools for reverse translational research and diagnostics, with a strong component of Services to the community. She is the Head of the Laboratory of Biochemical Genetics, Center for Neuroscience of Coimbra, since March 1995.
She has established several international collaborations aiming to bring new developments to the research group, namely at the Baylor College of Medicine (Houston, USA), University of Newcastle upon Type (UK), Mitochondrial Biology Unit - Medical Research Council (Cambridge , UK) and CICAB Clinical Research Centre Extremadura University Hospital and Medical School, (Badajoz, Spain).
She has settled a study group of Pharmacogenomics Research in 2007, with the goal of identifying complete genetic and metabolic profiles influencing metabolism and toxicity of xenobiotics (eg drugs) and Manuela Grazina is a member of the CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics (RIBEF) since February 2012.
Manuela Grazina coordinates a group of Reverse Translational Research in Mitochondrial Bigenomics and Pharmacogenomics, at the CNC, in close liaison with the Faculty of Medicine, University of Coimbra, since 2008.
She is an Assistant Professor at the Faculty of Medicine, University of Coimbra, where she has been teaching since 1996. Manuela Grazina is also teaching the discipline of Human Genetics in Universities of Évora (since 2010) and Algarve (since 2008), under the scope of cooperation between Universities, and collaborates in teaching with other Universities / Colleges (Faculties of Pharmacy of Lisbon and Coimbra, Institute of Biomedical Sciences Abel Salazar - Porto). Additionally, Manuela Grazina has been dedicated to the Certification of Quality and she is Director of Quality at CNC since 2006.
Manuela Grazina has a strong experience in organizing Advanced Courses (14, since 2010) and has also organized several scientific meetings, workshops and seminars.
She is the co -author of 32 "peer -reviewed" publications, including 4 book chapters and 74 abstracts published in proceedings of scientific meetings (majority indexed and peer-reviewed), as well as 380 scientific communications, 252 of which are posters , 48 conferences by invitation and 80 oral presentations.
Manuela Grazina is responsible for the supervision of 12 PhD theses (1 completed), 32 MSc (26 completed) and 20 monographs (all completed). She has been participating in 17 research funded projects, includes 2 (FCT), in which she is the Principal Investigator.
She has got her PhD in Biomedical Sciences in the area of Biochemical Genetics (2006), Graduated in Biomedicine (1997), Master in Cell Biology (specialization in Neurogenetics; 2004) and she has a degree in Biochemistry (5 years grade, pre – Bologna, 1991), at the University of Coimbra.
She is member of CNC as Researcher since 1992, and created the Laboratory of Biochemical Genetics (in CNC / FMUC) in 1995, at the University of Coimbra, with development of biochemical and genetic tests as tools for reverse translational research and diagnostics, with a strong component of Services to the community. She is the Head of the Laboratory of Biochemical Genetics, Center for Neuroscience of Coimbra, since March 1995.
She has established several international collaborations aiming to bring new developments to the research group, namely at the Baylor College of Medicine (Houston, USA), University of Newcastle upon Type (UK), Mitochondrial Biology Unit - Medical Research Council (Cambridge , UK) and CICAB Clinical Research Centre Extremadura University Hospital and Medical School, (Badajoz, Spain).
She has settled a study group of Pharmacogenomics Research in 2007, with the goal of identifying complete genetic and metabolic profiles influencing metabolism and toxicity of xenobiotics (eg drugs) and Manuela Grazina is a member of the CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics (RIBEF) since February 2012.
Manuela Grazina coordinates a group of Reverse Translational Research in Mitochondrial Bigenomics and Pharmacogenomics, at the CNC, in close liaison with the Faculty of Medicine, University of Coimbra, since 2008.
She is an Assistant Professor at the Faculty of Medicine, University of Coimbra, where she has been teaching since 1996. Manuela Grazina is also teaching the discipline of Human Genetics in Universities of Évora (since 2010) and Algarve (since 2008), under the scope of cooperation between Universities, and collaborates in teaching with other Universities / Colleges (Faculties of Pharmacy of Lisbon and Coimbra, Institute of Biomedical Sciences Abel Salazar - Porto). Additionally, Manuela Grazina has been dedicated to the Certification of Quality and she is Director of Quality at CNC since 2006.
Manuela Grazina has a strong experience in organizing Advanced Courses (14, since 2010) and has also organized several scientific meetings, workshops and seminars.
She is the co -author of 32 "peer -reviewed" publications, including 4 book chapters and 74 abstracts published in proceedings of scientific meetings (majority indexed and peer-reviewed), as well as 380 scientific communications, 252 of which are posters , 48 conferences by invitation and 80 oral presentations.
Manuela Grazina is responsible for the supervision of 12 PhD theses (1 completed), 32 MSc (26 completed) and 20 monographs (all completed). She has been participating in 17 research funded projects, includes 2 (FCT), in which she is the Principal Investigator.
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Results 1-49 of 49 (Search time: 1.217 seconds).
| Issue Date | Title | Author(s) | Type | Access | |
|---|---|---|---|---|---|
| 1 | 2010 | Abordagem farmacogenómica na doença de Alzheimer : variação genética associada a CYP2D6 | Martins, Patrícia Andreia Gabriel | masterThesis | openAccess |
| 2 | 16-Sep-2015 | Analysis of mitochondrial genome in frontotemporal lobar degeneration: Contribution of RNRs and correlation with the Biochemical Phenotype | Tavares, Raquel Inês Fernandes Martins | masterThesis | openAccess |
| 3 | 2011 | Análise do gene DGUOK em crianças com síndrome de depleção | Pereira, Carla Isabel Teixeira de Jesus | masterThesis | openAccess |
| 4 | 2012 | Análise experimental da patogenicidade de variações de sequência novas no genoma mitocondrial | Bacalhau, Mafalda Rita Avó | masterThesis | openAccess |
| 5 | 2009 | Análise farmacogenómica de efeitos secundários da analgesia epidural com morfina no tratamento da dor pós-cesariana | Valentim, Ana do Rosário Caleiro | masterThesis | openAccess |
| 6 | 2011 | Antenatal manifestations of mitochondrial disorders | Tavares, Mariana Silva Vide | masterThesis | openAccess |
| 7 | 2016 | Argininemia and plasma arginine bioavailability - predictive factors of mortality in the severe trauma patients? | Costa, Beatriz P. ; Martins, Paulo ; Veríssimo, Carla ; Simões, Marta ; Tomé, Marisa; Grazina, Manuela ; Pimentel, Jorge ; Sousa, Francisco Castro | article | openAccess |
| 8 | 2009 | Avaliação da actividade enzimática da cadeia respiratória mitocondrial na esclerose múltipla | Mendes, Cândida Elsa Frias | masterThesis | openAccess |
| 9 | 2011 | Avaliação do número de cópias do DNA mitocondrial como biomarcador no cancro do pulmão | Bonifácio, Ana Catarina da Silva | doctoralThesis | openAccess |
| 10 | Feb-2011 | AZT – Molécula de Morte e Sobrevivência Celular | Pinto, Catarina Inês Sanches | masterThesis | openAccess |
| 11 | 2011 | CD40 in oral squamous cell carcinoma : a posssible role as a new therapeutic target | Soares, Ana Margarida da Rosa | masterThesis | openAccess |
| 12 | Feb-2016 | Clinical and metabolic characterization of Bronco-Pulmonary Carcinoma in Surgical Stadium | Dias, José Alberto de Castro e. | masterThesis | openAccess |
| 13 | Jul-2013 | Coenzyme Q10 deficiency in mitochondrial DNA depletion syndromes | Montero, Raquel ; Grazina, Manuela ; López-Gallardo, Ester ; Montoya, Julio ; Briones, Paz ; Navarro-Sastre, Aleix ; Land, John M. ; Hargreaves, Iain P. ; Artuch, Rafael ; O'Callaghan, Maria del Mar ; Jou, Cristina ; Jimenez, Cecilia ; Buján, Nuria ; Pineda, Mercè ; García-Cazorla, Angels ; Nascimento, Andrés ; Perez-Dueñas, Belen ; Ruiz-Pesini, Eduardo ; Fratter, Carl ; Salviati, Leonardo ; Simões, Marta; Mendes, Cândida ; Santos, Maria João ; Diogo, Luísa ; Garcia, Paula ; Navas, Plácido | article | openAccess |
| 14 | 2014 | Comprehensive analysis of MYOC gene in primary open-angle glaucoma | Ferreira, Ana Filipa Bento | masterThesis | openAccess |
| 15 | 2014 | CYP2D6 genetic variation and predicted metabolic profile in post-cesarean section pain: pharmacogenetic interpretation | Quinta, Rosa Margarida Figueiredo | masterThesis | openAccess |
| 16 | 2016 | Deficiência das enzimas do ciclo de Krebs | Silva, Jaquelina Henriques | masterThesis | openAccess |
| 17 | 10-Jan-2018 | Establishing the pathogenicity of novel mitochondrial DNA sequence variations: a cell and molecular biology approach | Bacalhau, Mafalda Rita Avó | doctoralThesis | embargoedAccess (2 years) |
| 18 | 2010 | Estudo farmacogenético da acção do propofol no sistema energético mitocondrial em células hela | Lapa, Teresa Alexandra Santos Carvalho | masterThesis | openAccess |
| 19 | 8-Apr-2014 | Estudo in vivo de caracterização da reacção inflamatória pós implantação de biomateriais à base de hidroxiapatite para aplicação em Medicina Dentária | Figueiredo, Andreia Sofia de Paiva | doctoralThesis | openAccess |
| 20 | 2011 | Farmacogenomics and pain | Eufrásio, Ana Isabel Osório | masterThesis | openAccess |
| 21 | 2004 | Frontotemporal dementia and mitochondrial DNA transitions | Grazina, Manuela ; Silva, Filipe ; Santana, Isabel ; Santiago, Beatriz ; Mendes, Cândida ; Simões, Marta; Oliveira, Miguel ; Cunha, Luís ; Oliveira, Catarina | article | openAccess |
| 22 | 2016 | Functional Investigation of OXPHOS assembly factors in Leber’s Hereditary Optic Neuropathy | Fonseca, Maria Inês Arêlo Manso da | masterThesis | embargoedAccess |
| 23 | 2006 | Genetic basis of Alzheimer's dementia: role of mtDNA mutations | Grazina, M. ; Pratas, J. ; Silva, F. ; Oliveira, S. ; Santana, I. ; Oliveira, C. | article | openAccess |
| 24 | 27-Jan-2023 | GenEye24: Novel Rapid Screening Test for the Top-3 Leber's Hereditary Optic Neuropathy Pathogenic Sequence Variants | Martins, Sara; Santos, Maria João; Teixeira, Márcia; Diogo, Luisa ; Macário, Maria do Carmo; Pedro Marques, João; Fonseca, Pedro; Grazina, Manuela | article | openAccess |
| 25 | 20-Jun-2006 | Genoma mitocondrial e défice energético no diagnóstico das doenças da cadeia respiratória mitocondrial | Grazina, Maria Manuela Monteiro | doctoralThesis | openAccess |
| 26 | 2014 | Genotype-phenotype correlation in mitochondrial depletion syndrome due to DGUOK deficiency | Duarte, Sara Filipa Rosa | masterThesis | openAccess |
| 27 | 28-Jul-2017 | Glutaminemia prognostic significance in critical surgical patients - An analysis of plasma aminogram profile | Costa, Beatriz Pinto ; Martins, Paulo ; Veríssimo, Carla ; Simões, Marta ; Tomé, Marisa; Grazina, Manuela ; Pimentel, Jorge ; Sousa, Francisco Castro | article | openAccess |
| 28 | 2015 | Insights on attentional processing : magic as a new method of research | Gonçalves, Diana Pinto | masterThesis | openAccess |
| 29 | 30-Mar-2017 | Intestinal dysfunction in the critical trauma patients - An early and frequent event | Costa, Beatriz Pinto ; Martins, Paulo ; Veríssimo, Carla ; Simões, Marta ; Tomé, Marisa; Grazina, Manuela ; Pimentel, Jorge ; Sousa, Francisco Castro | article | openAccess |
| 30 | 2012 | Investigação do cross-talk genómico na neuropatia ótica hereditária de Leber | Sousa, Tânia Sofia Silva | masterThesis | openAccess |
| 31 | 2011 | Investigação do gene TWINKLE em casos de deleções múltiplas do mtDNA | Baptista, Vera Lúcia da Silva | masterThesis | openAccess |
| 32 | 2012 | Investigação do mtDNA nas doenças de Huntington e Parkinson | Fernandes, Sabrina | masterThesis | openAccess |
| 33 | 2012 | Investigação dos genes MT-CO na demência frontotemporal | Martins, Catarina Isabel Mendes | masterThesis | openAccess |
| 34 | 12-Sep-2018 | Investigation of genes associated to mitochondrial import and post-translational processing in LHON | Teixeira, Márcia Joana Nascimento | masterThesis | embargoedAccess |
| 35 | 2013 | Investigation of plasma ATP levels in frontotemporal lobar degeneration | Monteiro, Ana Rita | masterThesis | openAccess |
| 36 | 1-Nov-2013 | Long term cortical plasticity in visual retinotopic areas in humans with silent retinal ganglion cell loss | Almeida, Otília C. d' ; Mateus, Catarina ; Reis, Aldina ; Grazina, Manuela M. ; Castelo-Branco, Miguel | article | openAccess |
| 37 | 2014 | Metabolic effects of hypoxia in colorectal cancer by 13C NMR isotopomer analysis | Abrantes, Ana M. ; Tavares, Ludgero C. ; Pires, Salomé ; Casalta-Lopes, João ; Mendes, Cândida ; Simões, Marta ; Grazina, Manuela M. ; Carvalho, Rui A. ; Botelho, Maria Filomena | article | openAccess |
| 38 | 6-Jun-2017 | Mitochondrial DNA mutations and Hearing Loss Connection | Augusto, Paulo José Pina Barreto | masterThesis | closedAccess |
| 39 | May-2013 | Mitochondrial DNA variants in complex V coding genes contributing to frontotemporal lobar degeration | Abrantes, João Paulo Fernandes | masterThesis | openAccess |
| 40 | 2013 | Mitochondrial genome analysis in frontotemporal lobar degeneration : tRNAs contribution | Oliveira, Isabel Maria Isabel Maria Lopes de Matos | masterThesis | openAccess |
| 41 | 2021 | MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile | Jacinto, Sandra; Guerreiro, Patrícia; Oliveira, Rita Machado de; Oliveira, Teresa Cunha ; Santos, Maria João ; Grazina, Manuela ; Rego, A. Cristina ; Outeiro, Tiago F. | article | openAccess |
| 42 | 2014 | MT-CYB sequencing analysis in frontotemporal lobar degeneration | Gonçalves, Mónica Silveira | masterThesis | openAccess |
| 43 | 31-Aug-2021 | MYOC Gene Sequencing Analysis in Primary Open-Angle Glaucoma Patients from the Centre Region of Portugal | Silva, Filipe ; Ferreira, Filipa ; Faria, Pedro; Sobral, Isa ; Rodrigues, Mariana ; Pratas, João ; Silva, Filipe ; Grazina, Manuela ; Moura Pereira, José; Girão, Henrique ; Pereira, Paulo | article | openAccess |
| 44 | 29-Apr-2015 | Parto prematuro - Estudo epidemiológico e genético. O envolvimento do gene HBD1. | Domingues, Ana Patrícia | doctoralThesis | openAccess |
| 45 | 2014 | Pharmacogenomics of drug addiction | Macedo, Carolina Augusta Azevedo Ferreira de | masterThesis | openAccess |
| 46 | 2014 | (Re)defining the concept of "pathogenic mutation" : translational analysis of an unusual lhon case | Guiomar, Pedro Filipe Rebelo | masterThesis | openAccess |
| 47 | 19-Feb-2015 | Regulação genética do receptor 5-HT2A na Demência Frontotemporal | Luís, Daniela Filipa Ribeiro | doctoralThesis | embargoedAccess |
| 48 | Sep-2016 | Relevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population | Céspedes-Garro, Carolina; Rodrigues-Soares, Fernanda; Jiménez-Arce, Gerardo; Naranjo, María-Eugenia G; Tarazona-Santos, Eduardo; Fariñas, Humberto; Barrantes, Ramiro; Llerena, Adrián; Grazina, Manuela ; CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics & Pharmacogenomics RIBEFa | article | openAccess |
| 49 | 2011 | Variação genética do gene CYPD6 na analgesia do parto : abordagem farmacogenómica | Raposo, Ana Cristina Baptista | masterThesis | openAccess |