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Title: Frontotemporal dementia and mitochondrial DNA transitions
Authors: Grazina, Manuela 
Silva, Filipe 
Santana, Isabel 
Santiago, Beatriz 
Mendes, Cândida 
Simões, Marta
Oliveira, Miguel 
Cunha, Luís 
Oliveira, Catarina 
Keywords: Frontotemporal dementia; Point mutation; Mitochondrial respiratory chain; Hominoid primates; Age of onset; APO E gene
Issue Date: 2004
Citation: Neurobiology of Disease. 15:2 (2004) 306-311
Abstract: Frontotemporal dementia (FTD) is the second most common type of primary degenerative dementia. Some patients present an overlap between Alzheimer's disease (AD) and FTD both in neuropathological and clinical aspects. This may suggest a similar overlap in physiopathology, namely an involvement of mitochondrial DNA (mtDNA) in FTD, as it has been associated to AD. To determine if mtDNA is involved in FTD, we performed a Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) analysis, specific to mtDNA NADH Dehydrogenase subunit 1 (ND1) nucleotides 3337-3340, searching for mutations previously described in Parkinson's and AD patients. We could identify one FTD patient with two mtDNA transitions: one already known (3316 G-to-A) and another unreported (3337 G-to-A). Additionally, mitochondrial respiratory chain complex I activity was reduced in leukocytes of this patient (36% of the control mean activity). To our knowledge, this is the first report of mtDNA variants in FTD patients.
DOI: 10.1016/j.nbd.2003.11.004
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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