Loading... 2 0 20 0 false
 
Credit Name
Laranjinha, João
 
Name
Laranjinha, João
 
Variants
Laranjinha, João
 
 
 
Ciência ID
 
Scopus Author ID
 
Status
UC Researcher
Biography
João Laranjinha is professor of Biochemistry and Molecular Biology at the Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. He graduated in Pharmaceutical Sciences (University of Coimbra) in 1984 and got a PhD in Biochemistry (University of Coimbra) in 1996. He did Postdoc studies with Enrique Cadenas in 1997-1998 at the Dept. Molecular Pharmacology and Toxicology, University Southern California, Los Angeles, USA. His research is focused on the functional impact of nitric oxide in the brain as a neurometabolic regulator and as a mediator of neurovascular coupling with impact in aging and neurodegeneration. He is also interested in dietary nitrite-driven regulatory processes, encompassing the non-enzymatic production of nitric oxide along the nitrate:nitrite:NO pathway. He has been awarded several prizes, including the Science and Humanity award by The Oxygen Club of California and is member of the editorial board of major journals in his area of research, including Redox Biology, Free Radical Biology and Medicine, Archives of Biochemistry and Biophysics, Free Radical Research and Biofactors. He has chaired the organizing and scientific committees of several international conferences, including the European (SFRRE 2007) and International (SFRRI 2018) meetings of the Society for Free Radical Research. He has been member of the council of the European Society for Neurochemistry and the European Society for Free Radical Research for several years and President of the Portuguese Biochemical Society (2014-18). Currently, he serves as member of the Advanced Courses Committee of FEBS and as the president of the General Assembly of the Portuguese Biochemical Society.
Loading... 3 0 20 0 false

Publications

Results 1-61 of 61 (Search time: 0.002 seconds).

Issue DateTitleAuthor(s)TypeAccess
120083,4-Dihydroxyphenylacetic acid (DOPAC) modulates the toxicity induced by nitric oxide in PC-12 cells via mitochondrial dysfunctioningNunes, Carla ; Almeida, Leonor ; Laranjinha, João articleopenAccess
2Sep-2015Ação de flavonoides na doença inflamatória intestinalJin, LuyiotheropenAccess
32018Age-Dependent Impairment of Neurovascular and Neurometabolic Coupling in the HippocampusLourenço, Cátia F. ; Ledo, Ana ; Caetano, Miguel ; Barbosa, Rui M. ; Laranjinha, João articleopenAccess
4Jun-2014Alzheimer: diabetes tipo 3?Almeida, Mariana Matos deotheropenAccess
52003Antioxidant protection of low density lipoprotein by procyanidins: structure/activity relationshipsPorto, Patrícia Andréia Leite da Silva ; Laranjinha, João António Nave ; Freitas, Victor Armando Pereira de articleopenAccess
65-Dec-2012Biological role of nitrite and nitric oxide in the stomach: from diet to protein tyrosine with implications for gastric physiologyRocha, Bárbara Silva doctoralThesisopenAccess
715-Jun-2013Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brainSantos, Ricardo M. ; Rodrigues, Marcelo S. ; Laranjinha, João ; Barbosa, Rui M. articleopenAccess
81998Cholesteryl Ester Hydroperoxide Formation in Myoglobin-Catalyzed Low Density Lipoprotein Oxidation : Concerted Antioxidant Activity of Caffeic and p-Coumaric Acids with AscorbateVieira, Otília ; Laranjinha, João ; Madeira, Vítor ; Almeida, Leonor articleopenAccess
92000Citotoxicidade e sinalização em células endoteliais vasculares induzidas por lipoproteínas humanas (LDL) oxidadas: mecanismos de protecção por ácidos fenólicos da dietaVieira, Maria Otília Vitoriana doctoralThesisembargoedAccess
10Nov-2005Concentration Dynamics of Nitric Oxide in Rat Hippocampal SlicesLedo, Ana ; Barbosa, Rui M. ; Cadenas, Enrique ; Gerhardt, Greg ; Laranjinha, João articleopenAccess
1129-Nov-2005Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptorLedo, Ana ; Barbosa, Rui M. ; Gerhardt, Greg A. ; Cadenas, Enrique ; Laranjinha, João articleopenAccess
122006Detecção electroquímica de óxido nítrico em fatias de hipocampo de rato com micoeléctrodos de fibra de carbonoFerreira, Nuno Ricardo Esteves masterThesisopenAccess
13Jul-2014Diabetes tipo 3: uma nova perspectiva sobre a doença de AlzheimerMarques, João Gabriel de OliveiraotheropenAccess
1415-Nov-2007Dinâmica de concentração do óxido nítrico produzido no hipocampo de rato por activação de receptores do glutamatoLedo, Ana Margarida da Cruz doctoralThesisopenAccess
1526-Sep-2008Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitroBem, Andreza Fabro de ; Farina, Marcelo ; Portella, Rafael de Lima ; Nogueira, Cristina Wayne ; Dinis, Teresa C. P. ; Laranjinha, João A. N. ; Almeida, Leonor M. ; Rocha, João Batista Teixeira articleopenAccess
16Sep-2015Doença de Alzheimer e resistência à insulinaTuca, OctavianotheropenAccess
1730-Sep-2022Dynamic changes of aerobic brain oxidative metabolism revealed by lactate and the redox modulation by nitriteDias, Cândida Marília das NevesdoctoralThesisopenAccess
182005Electrochemical measurement of endogenously produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodesFerreira, Nuno R. ; Ledo, Ana ; Frade, João G. ; Gerhardt, Greg A. ; Laranjinha, João ; Barbosa, Rui M. articleopenAccess
192-Mar-2023Epigenetic Modifications Induced by the Gut Microbiota May Result from What We Eat: Should We Talk about Precision Diet in Health and Disease?Reva, Katerina; Laranjinha, João ; Rocha, Bárbara S. articleopenAccess
20Oct-2017European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)Egea, Javier; Fabregat, Isabel; Frapart, Yves M; Ghezzi, Pietro; Görlach, Agnes; Kietzmann, Thomas; Kubaichuk, Kateryna; Knaus, Ulla G.; Lopez, Manuela G.; Olaso-Gonzalez, Gloria; Petry, Andreas; Schulz, Rainer; Vina, Jose; Winyard, Paul; Abbas, Kahina; Ademowo, Opeyemi S.; Afonso, Catarina B.; Andreadou, Ioanna; Antelmann, Haike; Antunes, Fernando; Aslan, Mutay; Bachschmid, Markus M.; Barbosa, Rui M. ; Belousov, Vsevolod; Berndt, Carsten; Bernlohr, David; Bertrán, Esther; Bindoli, Alberto; Bottari, Serge P.; Brito, Paula M. ; Carrara, Guia; Casas, Ana I.; Chatzi, Afroditi; Chondrogianni, Niki; Conrad, Marcus; Cooke, Marcus S.; Costa, João G.; Cuadrado, Antonio; My-Chan Dang, Pham; De Smet, Barbara; Debelec-Butuner, Bilge; Dias, Irundika H K; Dunn, Joe Dan; Edson, Amanda J; El Assar, Mariam; El-Benna, Jamel; Ferdinandy, Péter; Fernandes, Ana S.; Fladmark, Kari E.; Förstermann, Ulrich; Giniatullin, Rashid; Giricz, Zoltán; Görbe, Anikó; Griffiths, Helen; Hampl, Vaclav; Hanf, Alina; Herget, Jan; Hernansanz-Agustín, Pablo; Hillion, Melanie; Huang, Jingjing; Ilikay, Serap; Jansen-Dürr, Pidder; Jaquet, Vincent; Joles, Jaap A; Kalyanaraman, Balaraman; Kaminskyy, Danylo; Karbaschi, Mahsa; Kleanthous, Marina; Klotz, Lars-Oliver; Korac, Bato; Korkmaz, Kemal Sami; Koziel, Rafal; Kračun, Damir; Krause, Karl-Heinz; Kren, Vladimir ; Krieg, Thomas; Laranjinha, João ; Lazou, Antigone; Li, Huige; Martínez-Ruiz, Antonio; Matsui, Reiko; McBean, Gethin J.; Meredith, Stuart P.; Messens, Joris; Miguel, Verónica; Mikhed, Yuliya; Milisav, Irina; Milković, Lidija; Miranda-Vizuete, Antonio; Mojović, Miloš; Monsalve, María; Mouthuy, Pierre-Alexis; Mulvey, John; Münzel, Thomas; Muzykantov, Vladimir; Nguyen, Isabel T. N.; Oelze, Matthias; Oliveira, Nuno G; Palmeira, Carlos M. ; Papaevgeniou, Nikoletta; Pavićević, Aleksandra; Pedre, Brandán; Peyrot, Fabienne; Phylactides, Marios; Pircalabioru, Gratiela G.; Pitt, Andrew R.; Poulsen, Henrik E.; Prieto, Ignacio; Rigobello, Maria Pia; Robledinos-Antón, Natalia; Rodríguez-Mañas, Leocadio; Rolo, Anabela P. ; Rousset, Francis; Ruskovska, Tatjana; Saraiva, Nuno Baía ; Sasson, Shlomo; Schröder, Katrin; Semen, Khrystyna; Seredenina, Tamara; Shakirzyanova, Anastasia; Smith, Geoffrey L.; Soldati, Thierry; Sousa, Bebiana C.; Spickett, Corinne M.; Stancic, Ana; Stasia, Marie José; Steinbrenner, Holger; Stepanić, Višnja; Steven, Sebastian; Tokatlidis, Kostas; Tuncay, Erkan; Turan, Belma; Ursini, Fulvio; Vacek, Jan; Vajnerova, Olga; Valentová, Kateřina; Van Breusegem, Frank; Varisli, Lokman; Veal, Elizabeth A.; Yalçın, A Suha; Yelisyeyeva, Olha; Žarković, Neven; Zatloukalová, Martina; Zielonka, Jacek; Touyz, Rhian M.; Papapetropoulos, Andreas; Grune, Tilman; Lamas, Santiago; Schmidt, Harald H H W; Di Lisa, Fabio; Daiber, AndreasarticleopenAccess
21Aug-2021A High Fat/Cholesterol Diet Recapitulates Some Alzheimer's Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial DysfunctionMancini, Gianni; Dias, Cândida ; Lourenço, Cátia F. ; Laranjinha, João ; Bem, Andreza de; Ledo, Ana articleopenAccess
222013High-Resolution Respirometry for Metabolic Profiling of Acute Rat Hippocampal SlicesHenriques, Tiago André Ferreira masterThesisopenAccess
23Dec-2013Human colon adenocarcinoma HT-29 cell: electrochemistry and nicotine stimulationOliveira, S. C. B. ; Santarino, I. B. ; Enache, T. A. ; Nunes, C. ; Laranjinha, J. ; Barbosa, R. M. ; Brett, A. M. Oliveira articleopenAccess
242022In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activityLedo, A. ; Fernandes, E. ; Salvador, A. ; Laranjinha, J. ; Barbosa, R. M. articleopenAccess
252000Inhibition of human LDL lipid peroxidation by phenol-rich beverages and their impact on plasma total antioxidant capacity in humansSerafini, Mauro ; Laranjinha, João A. N. ; Almeida, Leonor M. ; Maiani, G. articleopenAccess
2624-Sep-2018Innovative pathways underlying the etiology and the therapeutics via modulation of the gut microbiotaRibeiro, Ricardo Manuel EstevesmasterThesisopenAccess
2725-Sep-2020Internship report and thesis entitled “Diet, microbiota and epigenetics – a dynamic and adjustable triade to explore new treatment approaches”Reva, KaterinamasterThesisopenAccess
2828-May-2008LDL Isolated from Plasma-Loaded Red Wine Procyanidins Resist Lipid Oxidation and Tocopherol DepletionLourenço, Cátia F. ; Gago, Bruno ; Barbosa, Rui M. ; Freitas, Víctor de ; Laranjinha, João articleopenAccess
2926-Sep-2017O microbiota e o ser humanoQueiroz, João Pedro Nunes masterThesisopenAccess
306-Nov-2017Microbiota-host interactions during antibiotic therapy: unveiling novel redox signaling pathways with impact on gut homeostasisRocha, Bárbara Silva masterThesisclosedAccess
3128-Jul-2017Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arraysLourenço, Cátia F. ; Ledo, Ana ; Gerhardt, Greg A. ; Laranjinha, João ; Barbosa, Rui M. articleopenAccess
322015Neurovascular and neurometabolic derailment in aging and Alzheimer's diseaseLourenço, Cátia F. ; Ledo, Ana ; Dias, Cândida ; Barbosa, Rui M. ; Laranjinha, João articleopenAccess
332004Nitric oxide in brain: diffusion, targets and concentration dynamics in hippocampal subregionsLedo, Ana ; Frade, João ; Barbosa, Rui M. ; Laranjinha, João articleopenAccess
342012Nitric oxide inactivation mechanisms in the brain: role in bioenergetics and neurodegenerationSantos, Ricardo M. ; Lourenço, Cátia F. ; Ledo, Ana ; Barbosa, Rui M. ; Laranjinha, João articleopenAccess
352012Nitric oxide mediates neurovascular coupling in the brain effect of polyphenols in animal models of Alzheimer's diseaseFonseca, Ana rita de Jesus Alves da masterThesisopenAccess
362021Nitric Oxide Pathways in Neurovascular Coupling Under Normal and Stress Conditions in the Brain: Strategies to Rescue Aberrant Coupling and Improve Cerebral Blood FlowLourenço, Cátia F. ; Laranjinha, João articleopenAccess
37Sep-2016Nutrigenómica e qualidade de vida : funções e eficácia de moduladores de NRF2 presentes em suplementos da dietaOliveira, Luís Francisco Lourenço Vaz deotheropenAccess
38Jul-2014Obesidade e diabetes: o papel das citocinas do tecido adiposoMoura, Pedro Miguel Cruz HenriquesotheropenAccess
392002Oxidation of DOPAC by nitric oxide: effect of superoxide dismutaseLaranjinha, João ; Cadenas, Enrique articleopenAccess
4026-Jun-2019Pathophysiology of Doxorubicin Cardiotoxicity: From Mitochondrial Homeostasis to Biological ClocksFerreira, Luciana Carolina LopesdoctoralThesisembargoedAccess
412008The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditionsGago, Bruno ; Nyström, Thomas ; Cavaleiro, Carlos ; Rocha, Bárbara S. ; Barbosa, Rui M. ; Laranjinha, João ; Lundberg, Jon O. articleopenAccess
421996Pressão oxidativa em lipoproteínas humanas de baixa densidade (LDL): Mecanismos de antioxidação por ácidos fenólicos da dietaLaranjinha, João António Nave doctoralThesisembargoedAccess
43Dec-1996Rapid isolation of low density lipoproteins in a concentrated fraction free from water-soluble plasma antioxidantsVieira, Otília V. ; Laranjinha, João A. ; Madeira, Vítor M. ; Almeida, Leonor M. articleopenAccess
4415-Sep-2008Real-time change of nitric oxide in rat hippocampal slices and astrocytic glutathione release via glutamate-dependent pathwaysFrade, João Gonçalo Leal de Oliveira e Silva doctoralThesisopenAccess
452007Red wine-dependent reduction of nitrite to nitric oxide in the stomachGago, Bruno ; Lundberg, Jon O. ; Barbosa, Rui M. ; Laranjinha, João articleopenAccess
461999Redox Cycles of Caffeic Acid, alpha-Tocopherol, and Ascorbate: Implications for Protection of Low-Density Lipoproteins Against OxidationLaranjinha, João ; Cadenas, Enrique articleopenAccess
472005Redox interactions of nitric oxide with dopamine and its derivativesAntunes, Fernando ; Nunes, Carla ; Laranjinha, João ; Cadenas, Enrique articleopenAccess
483-Oct-2017Relatório de estágio e monografia intitulada :"mecanismos epigenéticos na formação de memória e capacidades cognitivas"Brazão, João António Lima de Andrade CondemasterThesisopenAccess
4914-Sep-2018Relatórios de Estágio e Monografia intitulada “Novas Estratégias Biomédicas: Modulação do Epigenoma e Terapia do Cancro"Arrais, Débora Gomes masterThesisopenAccess
503-Oct-2017Relatórios de Estágio e Monografia intitulada “O Parkinson, a Microbiota Intestinal e a Epigenética”Silva, Miguel Pereira da masterThesisopenAccess
51Aug-2016Role of nitrite, urate and pepsin in the gastroprotective effects of salivaRocha, Bárbara S. ; Lundberg, Jon O. ; Radi, Rafael; Laranjinha, João articleopenAccess
52Feb-2013Self-mixing microprobe for monitoring microvascular perfusion in rat brainFigueiras, Edite ; Oliveira, Ricardo ; Lourenço, Cátia F. ; Campos, Rita ; Humeau-Heurtier, Anne ; Barbosa, Rui M. ; Laranjinha, João ; Requicha Ferreira, Luís F. ; de Mul, Frits F M articleopenAccess
53Jul-2016Síndrome metabólico e dieta vegetariana: relação benéfica, deletéria ou irrelevante?Lijnzaat, Pedro de AzevedootheropenAccess
54Jul-2016The human microbiome: a fine line between symbiosis and pathogenesisGonçalves, João Miguel da SilvaotheropenAccess
551-Apr-2016The interplay of ascorbic acid, nitric oxide and nitrite in the brain and its role on the regulation of cerebral blood flow: an in vivo electrochemical studyFerreira, Nuno Ricardo Esteves doctoralThesisopenAccess
56Sep-2016The long and winding road of STAT3 in the mitochondriaRamos, Carlos Eduardo Cardanho dosotheropenAccess
57Jul-2016The pathogenesis of Parkinson Disease : the microbiota-gut-brain axisFernandes, Ana Rita CardosootheropenAccess
589-May-2013The redox interplay between nitrite and nitric oxide: From the gut to the brainPereira, Cassilda ; Ferreira, Nuno R. ; Rocha, Bárbara S. ; Barbosa, Rui M. ; Laranjinha, João articleopenAccess
5918-May-2016The role of nitrite-derived nitric oxide in gastric physiology: biochemical mechanisms, molecular targets and the modulatory effect of red winePereira, Cassilda Maria Lopes doctoralThesisopenAccess
602011The role of polyphenols and reactive nitrogen species in inflammatory conditions of the gastrointestinal tract|Ferreira, Elisabete Priscila Pinto masterThesisopenAccess
6118-Jan-2013Unravelling New Roles for SIRT1 in Mitochondrial BiollogyGomes, Ana Patrícia da Silva doctoralThesisopenAccess