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Title: LDL Isolated from Plasma-Loaded Red Wine Procyanidins Resist Lipid Oxidation and Tocopherol Depletion
Authors: Lourenço, Cátia F. 
Gago, Bruno 
Barbosa, Rui M. 
Freitas, Víctor de 
Laranjinha, João 
Issue Date: 28-May-2008
Publisher: American Chemical Society
Citation: Journal of Agricultural and Food Chemistry. 56:10 (2008) 3798-3804
Abstract: Dietary phenolic compounds may act as antioxidants in vitro, but because of structural modifications during absorption, its role based on concentrations high enough to afford an antioxidant protection needs to be re-evaluated. We have explored the hypothesis that red wine procyanidins interact with low density lipoproteins (LDL) and that, at this location, the phenolic compounds efficiently protect LDL from oxidation and maintain LDL α-tocopherol at a high steady state concentration by recycling it back from the α-tocopheroxyl radical. To this end, human plasma was supplemented with wine procyanidins and isolated LDL were challenged with a constant flux of peroxyl radicals. As compared with LDL from plasma-free procyanidins, those LDL better resisted lipid oxidation and exhibited longer lag-phases of α-tocopherol consumption. The procyanidins, depending on their structure, were able to reduce the UV-induced α-tocopherol radical in a micellar system, as evidenced by electron paramagnetic ressonance. Mechanistically, the protection of LDL was interpreted in terms of quenching of peroxyl radicals and the recycling of α-tocopherol by the procyanidins bound to the lipoproteins. These results support the notion that, in human plasma, the procyanidins, via binding to LDL, may act as efficient local antioxidants.
ISSN: 0021-8561
DOI: 10.1021/jf0733259
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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