Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5155
Title: Antioxidant protection of low density lipoprotein by procyanidins: structure/activity relationships
Authors: Porto, Patrícia Andréia Leite da Silva 
Laranjinha, João António Nave 
Freitas, Victor Armando Pereira de 
Keywords: Procyanidins; Antioxidant; Low density lipoproteins (LDL); cis-Parinaric acid; Conjugated dienes
Issue Date: 2003
Citation: Biochemical Pharmacology. 66:6 (2003) 947-954
Abstract: The antioxidant activity of catechins and oligomeric procyanidins against low density lipoproteins peroxidation was studied by means of three distinct methods: cis-parinaric acid fluorescence decay, conjugated-dienes detection, and oxygen consumption. A relationship between the radical trapping efficiency of procyanidins and their structure was investigated. The results indicated that: (i) interflavan linkage type (C4---C6 or C4---C8) exerts a significant effect upon radical-trapping antioxidant activity of procyanidins. It is suggested that the conformation adopted by each procyanidin in aqueous solution influence their hydrophilic character, hence affecting their interaction with the peroxyl radicals present in aqueous phase and those in LDL particle (lipidic nature); (ii) antioxidant activity increase with the degree of polymerization for the compounds with (-)-epicatechin (epi) as structural unit (epi, dimer B2 (epi-epi) and trimer C1 (epi-epi-epi)); (iii) galloylation increases antioxidant activity of procyanidins, specially in the case of B2-3''-O-gallate dimer, which revealed the maximal trapping efficiency.
URI: http://hdl.handle.net/10316/5155
DOI: 10.1016/S0006-2952(03)00458-1
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
file590ce68b7b7b407ab19a38b2b8e8bbdc.pdf269.42 kBAdobe PDFView/Open
Show full item record

WEB OF SCIENCETM
Citations 50

81
checked on Aug 2, 2022

Page view(s)

198
checked on Aug 11, 2022

Download(s)

340
checked on Aug 11, 2022

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.