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Credit Name
Cunha-Oliveira, Teresa
 
Name
Cunha-Oliveira, Teresa
 
Variants
Oliveira, M.T.
Cunha-Oliveira, T.
Oliveira, T.C.
 
Email
teresa.oliveira@uc-biotech.pt
 
 
 
Scopus Author ID
 
Researcher ID
 
Status
UC Researcher
Biography
Teresa Cunha-Oliveira got her PhD in Biology (Cell Biology) in 2007 from the University of Coimbra (Portugal), having contributed to introduce the role of mitochondria in the field of drug addiction, particularly concerning cocaine, heroin and amphetamine. In her first post-doctoral period (2007-2010) in the Center for Neuroscience and Cell Biology (CNC, Coimbra), she collaborated with a Medicinal Chemistry group at the University of Porto to uncover the cellular effects of a newly found chemical interaction between heroin and cocaine (speedball) that could have a great impact in the understanding of poly-drug abuse consequences. In her second post-doctoral period (2010-2012), she was focused on the role of mitochondria in neurodegenerative diseases, including Huntington’s disease (HD) and Parkinson’s disease. She became interested in the epigenetic mechanisms associated with long-term mitochondrial dysfunction and contributed to characterize the bioenergetic dysfunction in cybrids from HD patients, evidencing the involvement of pyruvate dehydrogenase (PDH) and the promising role of epigenetic modulators in reversing PDH and mitochondrial dysfunctions in HD models. From 2013 until now, she is part of the MitoXT group at the CNC, more interested in the role of mitochondria in drug toxicology and experimental therapeutics, especially doxorubicin (DOX), an anticancer agent with long-term cardiotoxic side-effects involving mitochondria. She contributed to describe DOX-induced mitochondrial dysfunction, transcriptional deregulation and epigenetic signalling using in vitro and in vivo models. Her current interests include the development and validation of innovative screening assays to assess mitochondrial health with applications in toxicology, diagnostics and development of innovative therapeutic strategies for personalized medicine.
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Publications
(All)

Results 1-61 of 61 (Search time: 0.002 seconds).

Issue DateTitleAuthor(s)TypeAccess
1Feb-2015Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human LymphoblastsNaia, Luana ; Ferreira, I. Luísa ; Cunha-Oliveira, Teresa ; Duarte, Ana I. ; Ribeiro, Márcio ; Rosenstock, Tatiana R. ; Laço, Mário N. ; Ribeiro, Maria J. ; Oliveira, Catarina R. ; Saudou, Frédéric ; Humbert, Sandrine ; Rego, A. Cristina articleopenAccess
22013Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondriaCunha-Oliveira, Teresa ; Silva, Lisbeth ; Silva, Ana Maria ; Moreno, António J. ; Oliveira, Catarina R. ; Santos, Maria S. articleopenAccess
32007Adaptation to oxidative stress in the chronic effects of cocaine and amphetamineCunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. articleopenAccess
41-Sep-2017Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicityFerreira, André ; Cunha-Oliveira, Teresa ; Simões, Rui F. ; Carvalho, Filipa S. ; Burgeiro, Ana ; Nordgren, Kendra ; Wallace, Kendall B. ; Oliveira, Paulo J. articleopenAccess
52015Analysis of pro-apoptotic protein trafficking to and from mitochondriaVega-Naredo, Ignacio ; Cunha-Oliveira, Teresa ; Serafim, Teresa L. ; Sardão, Vilma A. ; Oliveira, Paulo J. articleopenAccess
4617-Mar-2017Aula de Campo e Aula de Museu: Recursos didáticos para conteúdos com Paleontologia nos Ensinos Básico e SecundárioAzenha, Matilde Lopes de Oliveira doctoralThesisopenAccess
472009BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neuronsAlmeida, S. ; Laço, M. ; Cunha-Oliveira, T. ; Oliveira, C. R. ; Rego, A. C. articleopenAccess
48Nov-2017Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblastsCoelho, Ana R. ; Martins, Tatiana R. ; Couto, Renata ; Deus, Cláudia ; Pereira, Cláudia V. ; Simões, Rui F. ; Rizvanov, Albert A. ; Silva, Filomena ; Cunha-Oliveira, Teresa ; Oliveira, Paulo J. ; Serafim, Teresa L. articleopenAccess
49Sep-2011Bioenergetic dysfunction in Huntington's disease human cybridsFerreira, I. Luísa ; Cunha-Oliveira, Teresa ; Nascimento, Maria V. ; Ribeiro, Márcio ; Proença, M. Teresa ; Januário, Cristina ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
502008Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugsCunha-Oliveira, Teresa ; Rego, Ana Cristina ; Oliveira, Catarina R. articleopenAccess
5114-Oct-2023Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Reduction during Fetal Development in a Non-Human Primate ModelPereira, Susana P. ; Diniz, Mariana S. ; Tavares, Ludgero C. ; Cunha-Oliveira, Teresa ; Li, Cun; Cox, Laura A ; Nijland, Mark J. ; Nathanielsz, Peter W. ; Oliveira, Paulo J. articleopenAccess
52Feb-2012Consequences of mitochondrial dysfunction in Huntington's Disease and protection via phosphorylation pathwaysCunha-Oliveira, Teresa ; Ferreira, Ildete L. ; Rego, A. Cristina bookPartopenAccess
53Nov-2021Corrigendum to 'A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients'. [Redox Biology 45 (2021) 102037]Deus, Cláudia M. ; Pereira, Susana P. ; Cunha-Oliveira, Teresa ; Teixeira, José ; Simões, Rui F. ; Cagide, Fernando; Benfeito, Sofia; Borges, Fernanda; Raimundo, Nuno ; Oliveira, Paulo J. articleopenAccess
542005Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxideCunha-Oliveira, T. ; Rego, A. C. ; Morgadinho, M. T. ; Sarmento, A. ; Macedo, T. ; Oliveira, C. R. conferenceObjectopenAccess
552006Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxideCunha-Oliveira, Teresa ; Rego, A. Cristina ; Morgadinho, Maria Teresa ; Macedo, Tice ; Oliveira, Catarina Resende articleopenAccess
562013Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transitionBernardo, Telma C. ; Cunha-Oliveira, Teresa ; Serafim, Teresa L. ; Holy, Jon ; Krasutsky, Dmytro ; Kolomitsyna, Oksana ; Krasutsky, Pavel ; Moreno, A. J. M. ; Oliveira, Paulo J. articleopenAccess
57Sep-2012Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in micePereira, Frederico ; Cunha-Oliveira, Teresa ; Viana, Sofia ; Travassos, Ana Sofia ; Nunes, Sara ; Silva, Carlos ; Prediger, Rui ; Rego, Ana Cristina ; Ali, Syed ; Fontes Ribeiro, Carlos Alberto articleclosedAccess
5825-Nov-2019Doxorubicin persistently rewires cardiac circadian homeostasis in miceFerreira, Luciana L ; Cervantes, Marlene; Froufe, Hugo J. C.; Egas, Conceição ; Cunha-Oliveira, Teresa ; Sassone-Corsi, Paolo; Oliveira, Paulo J. articleembargoedAccess
592018Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytesCunha-Oliveira, Teresa ; Ferreira, Luciana L ; Coelho, Ana Raquel ; Deus, Cláudia M ; Oliveira, Paulo J articleopenAccess
602009Dysregulation of CREB Activation and Histone Acetylation in 3-Nitropropionic Acid-Treated Cortical Neurons: Prevention by BDNF and NGFAlmeida, Sandra ; Cunha-Oliveira, Teresa ; Laço, Mário ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
619-Mar-2012Efeito crónico da heroína e do peróxido de hidrogénio em células PC12Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Morgadinho, M. Teresa ; Macedo, Tice R. ; Oliveira, Catarina R. articleopenAccess
623-Dec-2020Effects of Extended Passaging on the BEAS-2B Cell Line, an in vitro Model of Human Lung Epithelium Established for the Study of Lung CarcinogenesisSobral, Margarida Conceição MoreiramasterThesisembargoedAccess
6310-Mar-2022Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational StatisticsSimões, Rui F. ; Oliveira, Paulo J. ; Oliveira, Teresa Cunha ; Pereira, Francisco B. articleopenAccess
6421-Sep-2018Experimental enhancement of cellular OXPHOS reliance for mitochondrial health assessments - Development and characterization of a rapid and efficient method to induce OXPHOS in skin fibroblasts, for the assessment of mitochondiral toxicity and protection.Costa, Cláudio Figueiredo masterThesisopenAccess
658-Mar-2012Expression of NR1/NR2B N-Methyl-d-Aspartate Receptors Enhances Heroin Toxicity in HEK293 CellsDomingues, António ; Cunha-Oliveira, Teresa ; Laço, Mário L. N. ; Macedo, Tice ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
6615-Nov-2012Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cellsRibeiro, Márcio ; Rosenstock, Tatiana ; Cunha-Oliveira, Teresa ; Ferreira, Ildete ; Oliveira, Catarina R. ; Rego, Ana Cristina articleopenAccess
672005Heroin-induced degeneration of cortical neurons involves mitochondria-dependent apoptosisCunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. articleopenAccess
68Aug-2018Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cellsAbreu, Patrícia L. ; Cunha-Oliveira, Teresa ; Ferreira, Leonardo M R ; Urbano, Ana M. articleopenAccess
698-Mar-2017Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's DiseaseNaia, Luana ; Cunha-Oliveira, Teresa ; Rodrigues, Joana ; Rosenstock, Tatiana R. ; Oliveira, Ana ; Ribeiro, Márcio ; Carmo, Catarina ; Oliveira-Sousa, Sofia I. ; Duarte, Ana I. ; Hayden, Michael R. ; Rego, A. Cristina articleopenAccess
703-Oct-2019Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic StressFerreira, Leonardo M. R. ; Cunha-Oliveira, Teresa ; Sobral, Margarida C. ; Abreu, Patrícia L. ; Alpoim, Maria Carmen ; Urbano, Ana M. articleopenAccess
719-Dec-2020Impact of Rebaudioside A in cancer cell metabolism: Potential as a safe chemotherapeutic adjuvantAfonso, Gonçalo José Martins masterThesisopenAccess
7218-Sep-2019Intracellular and Intercellular Mitochondrial Dynamics in Parkinson's DiseaseValdinocci, Dario; Simões, Rui F. ; Kovarova, Jaromira ; Cunha-Oliveira, Teresa ; Neuzil, Jiri ; Pountney, Dean LarticleopenAccess
73Aug-2016Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicitySilva, Ana Marta ; Barbosa, Inês A. ; Seabra, Cátia ; Beltrão, Nuno ; Santos, Raquel ; Vega-Naredo, Ignacio ; Oliveira, Paulo ; Cunha-Oliveira, Teresa articleopenAccess
74Mar-2016Ketogenic diets: from cancer to mitochondrial diseases and beyondBranco, Ana F. ; Ferreira, André ; Simões, Rui F. ; Magalhães-Novais, Sílvia ; Zehowski, Cheryl ; Cope, Elisabeth ; Silva, Ana Marta ; Pereira, Daniela ; Sardão, Vilma A. ; Cunha-Oliveira, Teresa articleopenAccess
752013Medical Toxicology of Drugs of AbuseCunha-Oliveira, Teresa ; Rego, Ana Cristina ; Carvalho, Félix ; Oliveira, Catarina R. bookPartopenAccess
761-Jul-2018Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative CapacityPereira, Susana P. ; Deus, Cláudia M. ; Serafim, Teresa L. ; Cunha-Oliveira, Teresa ; Oliveira, Paulo J. articleopenAccess
7710-May-2023Metabolic Priming as a Tool in Redox and Mitochondrial TheragnosticsPinho, Sónia A. ; Anjo, Sandra I. ; Cunha-Oliveira, Teresa articleopenAccess
5816-Sep-2019Mitochondria-based screening of drug neurotoxicity in differentiated SH-SY5Y cellsFerrão, Rafaela Margarida CuramasterThesisembargoedAccess
59Dec-2014Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblastsMoreira, Ana C. ; Branco, Ana F. ; Sampaio, Susana F. ; Cunha-Oliveira, Teresa ; Martins, Tatiana R. ; Holy, Jon ; Oliveira, Paulo J. ; Sardão, Vilma A. articleopenAccess
601-May-2013Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondriaCunha-Oliveira, Teresa ; Silva, Lisbeth ; Silva, Ana Maria ; Moreno, António J. ; Oliveira, Catarina R. ; Santos, Maria S. articleopenAccess
612006Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamineCunha-Oliveira, T. ; Rego, A. C. ; Cardoso, S. M. ; Borges, F. ; Swerdlow, R. ; Macedo, T. ; Oliveira, C. R. articleopenAccess
622020Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defectsDeus, Cláudia M. ; Pereira, Susana P. ; Cunha-Oliveira, Teresa ; Pereira, Francisco B. ; Raimundo, Nuno Filipe Viegas das Neves ; Oliveira, Paulo J. articleembargoedAccess
632011Molecular interaction between cocaine and opioids. Implications on Speedball's toxicityCunha-Oliveira, T. ; Silva, L. ; Silva, A. M. ; Santos, M. S. ; Garrido, J. ; Borges, F. ; Rego, A. C. ; Oliveira, C. R. conferenceObjectopenAccess
642021MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic ProfileJacinto, Sandra; Guerreiro, Patrícia; Oliveira, Rita Machado de; Oliveira, Teresa Cunha ; Santos, Maria João ; Grazina, Manuela ; Rego, A. Cristina ; Outeiro, Tiago F. articleopenAccess
657-Nov-2007Neuronal dysfunction induced by drugs of abuseOliveira, Maria Teresa Martins da Cunha doctoralThesisopenAccess
6620-Jul-2021Neuronal mitochondrial metabolism and dynamic profiling under physiological and pathological conditions using biological-based machine learning approachesSimões, Rui Fernando Vieira Lisboa Matias doctoralThesisembargoedAccess
672012Neurotoxicity of cocaineCunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. bookPartopenAccess
688-Mar-2012Neurotoxicity of heroin-cocaine combinations in rat cortical neuronsCunha-Oliveira, Teresa ; Rego, A. Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina R. articleopenAccess
6928-Aug-2014Oxidative Stress and Drugs of Abuse: An UpdateCunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. articleopenAccess
702020Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological InterventionCunha-Oliveira, Teresa ; Montezinho, Liliana ; Mendes, Catarina; Firuzi, Omidreza; Saso, Luciano; Oliveira, Paulo J. ; Silva, Filomena S. G. articleopenAccess
712021Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamineSimões, Rui F. ; Pino, Rute; Soares, Maurício Moreira ; Kovarova, Jaromira ; Neuzil, Jiri ; Travasso, Rui ; Oliveira, Paulo J.; Cunha-Oliveira, Teresa ; Pereira, Francisco B.articleopenAccess
725-Feb-2019Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer CellsBajzikova, Martina ; Kovarova, Jaromira ; Coelho, Ana R. ; Boukalova, Stepana ; Oh, Sehyun ; Rohlenova, Katerina ; Svec, David ; Hubackova, Sona ; Endaya, Berwini ; Judasova, Kristyna ; Bezawork-Geleta, Ayenachew ; Kluckova, Katarina ; Chatre, Laurent ; Zobalova, Renata ; Novakova, Anna ; Vanova, Katerina ; Ezrova, Zuzana ; Maghzal, Ghassan J ; Magalhaes Novais, Silvia ; Olsinova, Marie ; Krobova, Linda ; An, Yong Jin ; Davidova, Eliska ; Nahacka, Zuzana ; Sobol, Margarita ; Cunha-Oliveira, Teresa ; Sandoval-Acuña, Cristian ; Strnad, Hynek ; Zhang, Tongchuan ; Huynh, Thanh ; Serafim, Teresa L. ; Hozak, Pavel ; Sardão, Vilma A. ; Koopman, Werner J H ; Ricchetti, Miria ; Oliveira, Paulo J ; Kolar, Frantisek ; Kubista, Mikael ; Truksa, Jaroslav ; Dvorakova-Hortova, Katerina ; Pacak, Karel ; Gurlich, Robert ; Stocker, Roland ; Zhou, Yaoqi ; Berridge, Michael V ; Park, Sunghyouk ; Dong, Lanfeng ; Rohlena, Jakub ; Neuzil, Jiri articleembargoedAccess
53Sep-2013Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abusePerfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina articleopenAccess
541-Nov-2012Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abusePerfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina articleopenAccess
552017Role of Mitochondria on the Neurological Effects of CocainePereira, S.P. ; Cunha-Oliveira, T. articleopenAccess
56Jan-2015Role of mtDNA-related mitoepigenetic phenomena in cancerFerreira, André ; Serafim, Teresa L. ; Sardão, Vilma A. ; Cunha-Oliveira, Teresa articleopenAccess
5714-May-2021Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reductionPereira, Susana P. ; Tavares, Ludgero C. ; Duarte, Ana I. ; Baldeiras, Inês ; Cunha-Oliveira, Teresa ; Martins, João D. ; Santos, Maria S. ; Maloyan, Alina; Moreno, Antonio J. ; Cox, Laura A. ; Li, Cun; Nathanielsz, Peter W. ; Nijland, Mark J. ; Oliveira, Paulo J. articleembargoedAccess
58Feb-2019Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblastsFerreira, Luciana L. ; Cunha-Oliveira, Teresa ; Veloso, Caroline D. ; Costa, Cláudio F. ; Wallace, Kendall B. ; Oliveira, Paulo J. articleembargoedAccess
592007Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neuronsCunha-Oliveira, Teresa ; Rego, A. Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina Resende articleopenAccess
60Oct-2006Synthesis and Cytotoxic Profile of 3,4-Methylenedioxymethamphetamine (“Ecstasy”) and Its Metabolites on Undifferentiated PC12 Cells: A Putative Structure−Toxicity RelationshipMilhazes, Nuno ; Cunha-Oliveira, Teresa ; Martins, Pedro ; Garrido, Jorge ; Oliveira, Catarina ; Rego, A. Cristina ; Borges, Fernanda articleopenAccess
612014β-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?Branco, Ana F. ; Moreira, Ana C. ; Cunha-Oliveira, Teresa ; Couto, Renata ; Sardão, Vilma A. ; Rizvanov, Albert A. ; Palotas, Andras ; Oliveira, Paulo J. articleopenAccess