Title: Ketogenic diets: from cancer to mitochondrial diseases and beyond
Authors: Branco, Ana F. 
Ferreira, André 
Simões, Rui F. 
Magalhães-Novais, Sílvia 
Zehowski, Cheryl 
Cope, Elisabeth 
Silva, Ana Marta 
Pereira, Daniela 
Sardão, Vilma A. 
Cunha-Oliveira, Teresa 
Issue Date: Mar-2016
Publisher: Wiley
Project: PTDC/DTP-FTO/2433/2014 
info:eu-repo/grantAgreement/FCT/5876/147358/PT 
Abstract: BACKGROUND: The employment of dietary strategies such as ketogenic diets, which force cells to alter their energy source, has shown efficacy in the treatment of several diseases. Ketogenic diets are composed of high fat, moderate protein and low carbohydrates, which favour mitochondrial respiration rather than glycolysis for energy metabolism. DESIGN: This review focuses on how oncological, neurological and mitochondrial disorders have been targeted by ketogenic diets, their metabolic effects, and the possible mechanisms of action on mitochondrial energy homeostasis. The beneficial and adverse effects of the ketogenic diets are also highlighted. RESULTS AND CONCLUSIONS: Although the full mechanism by which ketogenic diets improve oncological and neurological conditions still remains to be elucidated, their clinical efficacy has attracted many new followers, and ketogenic diets can be a good option as a co-adjuvant therapy, depending on the situation and the extent of the disease.
URI: http://hdl.handle.net/10316/44842
ISSN: 1365-2362
DOI: 10.1111/eci.12591
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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