Ramalho-Santos, João

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Credit Name
Ramalho-Santos, João
 
Full Name
Santos, João Ramalho de Sousa
 
 
 
 
Scopus Author ID
 
Researcher ID
 
Biography
João Ramalho-Santos is Professor at the Department of Life Sciences, University of Coimbra, Portugal, where he concluded his Ph.D in Cell Biology in 1997. He was a post-doctoral fellow in Reproductive Biology at Oregon Health & Science University USA (1997-2000), a Visiting Scientist at University of Pittsburgh, USA (2003-2006) and a Fulbright Fellow at University of California San Francisco, USA (2009). He currently is the Head of the Biology of Reproduction and Stem Cells Group at the Center for Neuroscience and Cell Biology at the University of Coimbra where he works on the bioenergetics and metabolism of gametes and stem cells, and on Science Communication and Bioethics issues related both to Assisted Reproduction and metabolism, aging and disease.
He is also Director of the Center for Neuroscience and Cell Biology.
He is Associate Editor of the Journals Reproduction and Human Reproduction, reviewer for over 30 journals and 6 agencies (Including FCT, Portugal, MRC, UK, and DFG, Germany). He is a former member of the National Ethics Council for the Life Sciences (CNECV)
h-Factor 47 (Google Scholar), 38 (ISI)
Citations: 8500 (Google Scholar), 5100 (ISI)
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Status
UC Researcher
 

Publications

Results 1-88 of 88 (Search time: 0.002 seconds).

Issue DateTitleAuthor(s)TypeAccess
12001Acrosome components after intracytoplasmic sperm injection: the decondensation frontierRamalho-Santos, João ; Simerly, Calvin R. ; Hewitson, Laura ; Schatten, Gerald articleopenAccess
227-Jun-1997Actividade fusogénica de vírus com envelope lipídico : fusão de membranas promovida pelos vírus influenza e SendaiSantos, João Ramalho de Sousa doctoralThesisembargoedAccess
32012Acute effects of TCDD administration: special emphasis on testicular and sperm mitochondrial functionMota, Paula C. ; Tavares, Renata S. ; Cordeiro, Marília ; Pereira, Susana P. ; Publicover, Stephen J. ; Oliveira, Paulo J. ; Ramalho-Santos, João articleopenAccess
47-Oct-2019Analysis of metabolic heterogeneity over cell division cycle in non-synchronized yeast a 13c based experimental-computational approachSantos, Inês Vasconcelos MirandadoctoralThesisopenAccess
512-Sep-2019Analysis of the Efficacy and Safety of Spermicides with Benzalkonium Cholride and Myristalkonium Chloride as Active PrinciplesAlfaiate, Maria Inês RodriguesmasterThesisclosedAccess
62013Anterior positioning of sex chromosomes on the head of human sperm sorted using visible wavelengthsAlçada-Morais, Sofia ; Sousa, Ana Paula ; Paiva, Artur ; Almeida-Santos, Teresa ; Ramalho-Santos, J. articleopenAccess
718-Dec-2012Approaches to Improve the Differentiation, Maturation and Biological Activity of Vascular Cells Derived from Stem CellsVazão, Helena Sofia Esmeraldo de Campos doctoralThesisopenAccess
82012Avaliação da integridade da cromatina em espermatozóides humanos : relevância clínicaSilva, Andreia Filipa Neves da masterThesisopenAccess
92012Biomarcadores em tumores das células germinativasSimões, Sónia Catarina Lopes masterThesisopenAccess
102018Bridging Health and Social Care with the Citizens – The Case of EIT Health Project “Healiqs4cities” and “Praça Vida+”, in PortugalSá-Moura, Bebiana; Couceiro, Patrícia; Catarino, Luis; Guardado, Diana; Brito, Maja de; Silva, Bárbara ; Tavares, Rui; Ramalho-Santos, João ; Teixeira, Ana M. ; Rama, Luís ; Reis, Flávio ; Mota-Pinto, Anabela ; Veríssimo, Manuel ; Gonçalves, Carlos ; Cunha, António; Malva, João O. articleopenAccess
112012Calcium mobilisation in human sperm and its effects on motilityFernandes, Leonor Cruz masterThesisopenAccess
122014A Cat Problem: Characterization of Feline Spermatogonial Stem CellsRebelo, Sara de Jesus Gomes Escada masterThesisopenAccess
132007Characterization of human sperm populations using conventional parameters, surface ubiquitination, and apoptotic markersVarum, Sandra ; Bento, Carla ; Sousa, Ana Paula M. ; Gomes-Santos, Carina S. S. ; Henriques, Paula ; Almeida-Santos, Teresa ; Teodósio, Cristina ; Paiva, Artur ; Ramalho-Santos, João articleopenAccess
1418-Jan-2016Characterization of KIR2DS1+ decidual Natural Killer cells in healthy and viral/bacterial – infected human pregnancyCrespo, Ângela Pascoal da Costa doctoralThesisopenAccess
15Mar-1993A common mechanism for influenza virus fusion activity and inactivationRamalho-Santos, João ; Nir, Shlomo ; Düzgünes, Nejat ; Carvalho, Arsélio Pato de ; Lima, Maria da Conceição Pedroso de articleopenAccess
1610-Sep-2018Comparação de parâmetros mitocondriais entre oócitos jovens e envelhecidosFernandes, Raquel Direito masterThesisclosedAccess
172006Comparison between different markers for sperm quality in the cat: Diff-Quik as a simple optical technique to assess changes in the DNA of feline epididymal spermMota, Paula C. ; Ramalho-Santos, João articleopenAccess
1822-Dec-2015Desafios na Inovação da Comunicação de Ciência em PortugalAmaral, Sara Varela doctoralThesisopenAccess
19Jan-2011Differential effects of p,p'-DDE on testis and liver mitochondria: implications for reproductive toxicologyMota, Paula C ; Cordeiro, Marília ; Pereira, Susana P ; Oliveira, Paulo J ; Moreno, António J ; Ramalho-Santos, João articleopenAccess
20Sep-2013Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar ratsPereira, Susana P ; Pereira, Gonçalo C ; Pereira, Cláudia V ; Carvalho, Filipa S ; Cordeiro, Marília H ; Mota, Paula C ; Ramalho-Santos, João ; Moreno, António J ; Oliveira, Paulo J articleopenAccess
212013Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar ratsPereira, Susana P. ; Pereira, Gonçalo C. ; Pereira, Cláudia V. ; Carvalho, Filipa S. ; Cordeiro, Marília H. ; Mota, Paula C. ; Ramalho-Santos, J. ; Moreno, A. J. M. ; Oliveira, Paulo J. articleopenAccess
222009Dual use of Diff-Quik-like stains for the simultaneous evaluation of human sperm morphology and chromatin statusSousa, Ana Paula M. ; Tavares, Renata S. ; Velez de la Calle, Juan Felipe ; Figueiredo, Helena ; Almeida, Vasco ; Almeida-Santos, Teresa ; Ramalho-Santos, João articleopenAccess
2320-Sep-2017Edible mushrooms as mediators of sustainability and human healthGomes, Cátia de Fátima Pires masterThesisopenAccess
242006Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetesAmaral, Sandra ; Moreno, António J. ; Santos, Maria Sancha ; Seiça, Raquel ; Ramalho-Santos, João articleopenAccess
252012Effects of Nicotine, Anandamide and Sildenafil Citrate in Sperm Function: The Role of the MitochondriaSousa, Maria Inês Ramalho de Almeida e masterThesisopenAccess
2617-Jun-2011Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated CounterpartsVarum, Sandra ; Rodrigues, Ana S. ; Moura, Michelle B. ; Momcilovic, Olga ; Easley, Charles A. ; Ramalho-Santos, João ; Van Houten, Bennett ; Schatten, Gerald articleopenAccess
2719-Sep-2018Estimulação angiogénica de tecido ovárico criopreservadoReis, Maria Carolina Pereira masterThesisembargoedAccess
2813-Sep-2013Estudo de subpopulações de espermatozóides com base no conteúdo em espécies reativas de oxigénio mitocondriaisMarques, Mónica João da Conceição masterThesisclosedAccess
2917-Sep-2019Evaluation of ageing-related molecular and bioenergetic alterations in bovine oocytesSoares, Maria MoreiramasterThesisclosedAccess
302013Evaluation of human sperm chromatin status after selection using a modified Diff-Quik stain indicates embryo quality and pregnancy outcomes following in vitro fertilizationTavares, R. S. ; Silva, A. F. ; Lourenço, B. ; Almeida-Santos, T. ; Sousa, A. P. ; Ramalho-Santos, J. articleopenAccess
312006Flow cytometry evaluation of lead and cadmium effects on mouse spermatogenesisOliveira, Helena ; Loureiro, João ; Filipe, Luísa ; Santos, Conceição ; Ramalho-Santos, João ; Sousa, Mário ; Pereira, Maria de Lourdes articleopenAccess
322002Fluorescent probes for monitoring virus fusion kinetics: comparative evaluation of reliabilityNunes-Correia, Isabel ; Eulálio, Ana ; Nir, Shlomo ; Düzgünes, Nejat ; Ramalho-Santos, João ; Lima, Maria C. Pedroso de articleopenAccess
3328-Dec-2017Framing Pluripotency: from gene to imagePerestrelo, Tânia Marisa Melim doctoralThesisembargoedAccess
342008Freeze-dried primate sperm retains early reproductive potential after intracytoplasmic sperm injectionSánchez-Partida, Luis Gabriel ; Simerly, Calvin R. ; Ramalho-Santos, João articleopenAccess
352001Fusion and Infection of Influenza and Sendai Viruses as Modulated by Dextran Sulfate: A Comparative StudyRamalho-Santos, João ; Lima, Maria Pedroso de articleopenAccess
362011Generation of a reporter system for monitorization of endothelial differentiationLima, Ana Francisca Silva de masterThesisopenAccess
3723-Mar-2015Generation of a VASA/GDF-9/ZP3-promoter driven triple transgenic reporter mouse line as a tool to study ovarian dynamicsCordeiro, Marília Henriques doctoralThesisopenAccess
38May-2002Golgi apparatus dynamics during mouse oocyte in vitro maturation: effect of the membrane trafficking inhibitor brefeldin AMoreno, Ricardo D. ; Schatten, Gerald ; Ramalho-Santos, João articleopenAccess
399-Nov-2020Heavy Metal Exposure And Its Effects In Male Reproductive Health: An In Vivo And In Vitro StudyCarola, Carolina MatosmasterThesisembargoedAccess
4010-Sep-2020High Fructose Feeding and Hepatic Fatty Liver Disease Inflammation: The Role of Intestinal MicrobiotaSilva, João Carlos Pinho da doctoralThesisopenAccess
412006Histopathological Effects of Hexavalent Chronium in Mouse KidneyOliveira, H. ; Santos, T. M. ; Ramalho-Santos, J. ; Pereira, M. de Lourdes articleopenAccess
422008Human sperm mitochondrial function : implications for male (in)fertilityAmaral, Maria Alexandra Barreto doctoralThesisopenAccess
4330-Jul-2015Human sperm mobility: proteins and metabolites towards the same journey's endPaiva, Carla Patrícia Rodrigues doctoralThesisopenAccess
4416-May-2011In Vitro Surfactant Structure-Toxicity Relationships: Implications for Surfactant Use in Sexually Transmitted Infection Prophylaxis and ContraceptionInácio, Ângela S. ; Mesquita, Katia A. ; Baptista, Marta ; Ramalho-Santos, João ; Vaz, Winchil L. C. ; Vieira, Otília V. articleopenAccess
452011Infertilidade equina : múltiplas fragilidades ou um "fado" do espermatozóideGamboa, Sandra Cristina de Oliveira Pinto doctoralThesisopenAccess
461998The influenza virus hemagglutinin: a model protein in the study of membrane fusionRamalho-Santos, João ; Pedroso de Lima, Maria C. articleopenAccess
472012Influência dos abusos estudantis durante os festejos académicos nos espermatozóidesAlmeida, Ana Karina Lopes masterThesisopenAccess
482-Dec-2013Inhibition of Mitochondrial Complex III Blocks Neuronal Differentiation and Maintains Embryonic Stem Cell PluripotencySandro, L. Pereira ; Grãos, Mário ; Rodrigues, Ana Sofia ; Anjo, Sandra I. ; Carvalho, Rui A. ; Oliveira, Paulo J. ; Arenas, Ernest ; Ramalho-Santos, João articleopenAccess
492014Insights into the reproductive dysfunction in diabetes : an in vitro approachPortela, Joana Mafalda Diogo masterThesisopenAccess
5019-Jan-1999Interactions of Influenza Virus with Cultured Cells: Detailed Kinetic Modeling of Binding and EndocytosisNunes-Correia, Isabel ; Ramalho-Santos, João ; Nir, Shlomo ; Lima, Maria C. Pedroso de articleopenAccess
511992Kinetic modeling of Sendai virus fusion with PC-12 cells. Effect of pH and temperature on fusion and viral inactivationLima, Maria da Conceição Pedroso de ; Ramalho-Santos, João ; Martins, Maria de Fátima ; Carvalho, Arsélio Pato de ; Bairos, Vasco ; Nir, Shlomo articleopenAccess
5228-Jan-2010Linking open chromatin to pluripotency in ES cells : the role of the chromatin remodeler Chd1Maia, Alexandre Gaspar doctoralThesisopenAccess
532003LIS1 association with dynactin is required for nuclear motility and genomic union in the fertilized mammalian oocytePayne, Christopher ; John, Justin C. St. ; Ramalho-Santos, João ; Schatten, Gerald articleopenAccess
542015Mechanisms and possible function of SIRT3 in mESCRibeiro, Marcelo Filipe Maleiro masterThesisopenAccess
551-Dec-2014Mechanisms of induced pluripotency: The role of the Nucleosome Remodelling and Deacetylase complexSantos, Rodrigo Luiz dos doctoralThesisembargoedAccess
5627-Jan-2016Mechanisms underlying metabolic shift in pluripotent stem cells: The potential role of sirtuinsCorreia, Marcelo José Marques doctoralThesisopenAccess
572001Membrane Trafficking Machinery Components Associated with the Mammalian Acrosome during SpermiogenesisRamalho-Santos, João ; Moreno, Ricardo D. ; Wessel, Gary M. ; Chan, Edward K. L. ; Schatten, Gerald articleopenAccess
582013Mitochondria and mammalian reproductionRamalho-Santos, J. ; Amaral, Sandra articleopenAccess
592013Mitochondria functionality and sperm qualityAmaral, Alexandra ; Lourenço, Bárbara ; Marques, Mónica ; Ramalho-Santos, J. articleopenAccess
6019-May-2010Mitochondria modulate pluripotency in human embryonic stem cellsVarum, Sandra Filipa Tavares doctoralThesisembargoedAccess
6130-Apr-2009Mitochondrial bioenergetics of testicular cells from the domestic cat (Felis catus)--A model for endangered speciesMota, Paula ; Amaral, Sandra ; Martins, Luís ; Pereira, Maria de Lourdes ; Oliveira, Paulo J. ; Ramalho-Santos, João articleopenAccess
622009A mitocôndria testicular como novo modelo toxicológico para avaliar correctamente o efeito de poluentes ambientais na reprodução masculina : estudo comparativo do impacto do DDE [1,1 -dicloro-2,2-bis(p-clorofenil)etileno] e TCDD (2,3,7,8-tetraclorodibenzo-p-dioxina) na bioenergética mitocondrial de testículo e fígadoCordeiro, Marília Henriques masterThesisopenAccess
63Mar-2004Mouse genetic corneal disease resulting from transgenic insertional mutagenesisRamalho, J. S. ; Gregory-Evans, K. ; Huxley, C. ; Seabra, M. C. articleopenAccess
6423-Mar-2011Not All Sperm Are Equal: Functional Mitochondria Characterize a Subpopulation of Human Sperm with Better Fertilization PotentialSousa, Ana Paula ; Amaral, Alexandra ; Baptista, Marta ; Tavares, Renata ; Caballero Campo, Pedro ; Caballero Peregrín, Pedro ; Freitas, Albertina ; Paiva, Artur ; Almeida-Santos, Teresa ; Ramalho-Santos, João articleopenAccess
652013p,p′-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrationsTavares, Renata S. ; Mansell, Steven ; Barratt, Christopher L. R. ; Wilson, Stuart M. ; Publicover, Stephen J. ; Ramalho-Santos, João articleopenAccess
662009Parabens in male infertility--Is there a mitochondrial connection?Tavares, Renata S. ; Martins, Fátima C. ; Oliveira, Paulo J. ; Ramalho-Santos, João ; Peixoto, Francisco P. articleopenAccess
6727-Sep-1996Partial fusion activity of influenza virus toward liposomes and erythrocyte ghosts is distinct from viral inactivationRamalho-Santos, João ; Lima, Maria C. Pedroso de ; Nir, Shlomo articleopenAccess
682014Preservação da fertilidade: maturação in vitro de oócitos pré ou pós vitrificaçãoMachado, Solange dos Santos Carril masterThesisopenAccess
692008The quantification of lipid and protein oxidation in stallion spermatozoa and seminal plasma: Seasonal distinctions and correlations with DNA strand breaks, classical seminal parameters and stallion fertilityMorte, Maria Inês ; Rodrigues, Ana Margarida ; Soares, Diana ; Rodrigues, Ana Sofia ; Gamboa, Sandra ; Ramalho-Santos, João articleopenAccess
7020-Sep-2018Quiet! They May Be at Rest: Metabolic Regulation of Paused Pluripotency.Silva, Bibiana Correia da masterThesisembargoedAccess
7118-Sep-2008Regulation of apoptosis and differentiation by P53 in human embryonic stem cellsGrandela, Ana Catarina Martins doctoralThesisopenAccess
7216-Mar-1999Role of a Transbilayer pH Gradient in the Membrane Fusion Activity of the Influenza Virus Hemagglutinin: Use of the R18 Assay to Monitor Membrane MergingRamalho-Santos, João ; Lima, Maria C. Pedroso de articleopenAccess
732004The role of target membrane sialic acid residues in the fusion activity of the influenza virus: the effect of two types of ganglioside on the kinetics of membrane mergingRamalho-Santos, João ; Lima, João Pedroso De articleopenAccess
742012Selecção de ovócitos para as técnicas de reprodução assistida com base no estudo das células do CumuolusLourenço, Bárbara Sofia Leitão Pinhão masterThesisopenAccess
751-Sep-2008Seminal traits, suitability for semen preservation and fertility in the native Portuguese horse breeds Puro Sangue Lusitano and Sorraia: Implications for stallion classification and assisted reproductionGamboa, Sandra ; Machado-Faria, Manuel ; Ramalho-Santos, João articleopenAccess
761998Sendai Virus Fusion Activity as Modulated by Target Membrane ComponentsNunes-Correia, Isabel ; Ramalho-Santos, João ; Pedroso de Lima, Maria C. articleopenAccess
772004Simultaneous analysis of cytoskeletal patterns and chromosome positioning in human fertilization failuresRamalho-Santos, João ; Amaral, Alexandra ; Brito, Raquel ; Freitas, Mariana ; Santos, Teresa Almeida articleopenAccess
782005SNARE proteins and caveolin-1 in stallion spermatozoa: possible implications for fertilityGamboa, Sandra ; Ramalho-Santos, João articleopenAccess
792000SNAREs in Mammalian Sperm: Possible Implications for FertilizationRamalho-Santos, João ; Moreno, Ricardo D. ; Sutovsky, Peter ; Chan, Anthony Wing-Sang ; Hewitson, Laura ; Wessel, Gary M. ; Simerly, Calvin R. ; Schatten, Gerald articleopenAccess
8015-Jul-2020Sperm quality in patients with infertility of unknown origin.Cristo, Maria Inês SousamasterThesisembargoedAccess
812008Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leakAmaral, Sandra ; Mota, Paula ; Rodrigues, Ana Sofia ; Martins, Luís ; Oliveira, Paulo J. ; Ramalho-Santos, João articleopenAccess
822009Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic ratsAmaral, Sandra ; Mota, Paula C. ; Lacerda, Beatriz ; Alves, Marco ; Pereira, Maria de Lourdes ; Oliveira, Paulo J. ; Ramalho-Santos, João articleopenAccess
8313-Feb-2014The role of metabolism and mitochondrial function in embryonic stem cellsRodrigues, Ana Sofia doctoralThesisembargoedAccess
8415-Jul-2014A two-sided tale : the influence of environmental endocrine disruptors and sperm chromatin status on male fertilitySantos Tavares, Renata doctoralThesisopenAccess
859-Apr-2014Unraveling the mechanisms of spermicidal activity by surfactants: their potential use as multi-functional compoundsBaptista, Marta Isabel Rodrigues doctoralThesisopenAccess
862013UVB irradiation as a tool to assess ROS-induced damage in human spermatozoaAmaral, S. ; Redmann, K. ; Sanchez, V. ; Mallidis, C. ; Ramalho-Santos, J. ; Schlatt, S. articleopenAccess
872002VAMP/synaptobrevin as an acrosomal marker for human spermRamalho-Santos, João ; Terada, Yukihiro ; Schatten, Gerald articleopenAccess
882010Vias metabólicas e funcionalidade de espermatozóides humanosPaiva, Carla Patrícia Rodrigues masterThesisopenAccess