Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/7898
Título: Chenodeoxycholate Is a Potent Inducer of the Permeability Transition Pore in Rat Liver Mitochondria
Autor: Rolo, Anabela 
Oliveira, Paulo 
Moreno, António 
Palmeira, Carlos 
Data: 2001
Citação: Bioscience Reports. 21:1 (2001) 73-80
Resumo: Several reports support the concept that bile acids may be cytotoxic during cholestatic disease process by causing mitochondrial dysfunction. Here we report additional data and findings aimed at a better understanding of the involvement of the permeability transition pore (PTP) opening in bile acids toxicity. The mitochondrial PTP is implicated as a mediator of cell injury and death in many situations. In the presence of calcium and phosphate, chenodeoxycholic acid (CDCA) induced a permeability transition in freshly isolated rat liver mitochondria, characterized by membrane depolarization, release of matrix calcium, and osmotic swelling. All these events were blocked by cyclosporine A (CyA) and the calcium uniporter inhibitor ruthenium red (RR). The results suggest that CDCA increases the sensitivity of isolated mitochondria in vitro to the calcium-dependent induction of the PTP.
URI: https://hdl.handle.net/10316/7898
DOI: 10.1023/A:1010438202519
Direitos: openAccess
Aparece nas coleções:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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