Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/7898
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rolo, Anabela | - |
dc.contributor.author | Oliveira, Paulo | - |
dc.contributor.author | Moreno, António | - |
dc.contributor.author | Palmeira, Carlos | - |
dc.date.accessioned | 2009-02-17T10:36:01Z | - |
dc.date.available | 2009-02-17T10:36:01Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | Bioscience Reports. 21:1 (2001) 73-80 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/7898 | - |
dc.description.abstract | Several reports support the concept that bile acids may be cytotoxic during cholestatic disease process by causing mitochondrial dysfunction. Here we report additional data and findings aimed at a better understanding of the involvement of the permeability transition pore (PTP) opening in bile acids toxicity. The mitochondrial PTP is implicated as a mediator of cell injury and death in many situations. In the presence of calcium and phosphate, chenodeoxycholic acid (CDCA) induced a permeability transition in freshly isolated rat liver mitochondria, characterized by membrane depolarization, release of matrix calcium, and osmotic swelling. All these events were blocked by cyclosporine A (CyA) and the calcium uniporter inhibitor ruthenium red (RR). The results suggest that CDCA increases the sensitivity of isolated mitochondria in vitro to the calcium-dependent induction of the PTP. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Chenodeoxycholate Is a Potent Inducer of the Permeability Transition Pore in Rat Liver Mitochondria | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1023/A:1010438202519 | en_US |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | MARE - Marine and Environmental Sciences Centre | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-3535-9630 | - |
crisitem.author.orcid | 0000-0002-5201-9948 | - |
crisitem.author.orcid | 0000-0003-3575-7604 | - |
crisitem.author.orcid | 0000-0002-2639-7697 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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