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https://hdl.handle.net/10316/47559
Title: | Cardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mitochondrial function | Authors: | Pereira, Gonçalo C. Pereira, Susana P. Tavares, Ludgero C. Carvalho, Filipa S. Magalhães-Novais, Sílvia Barbosa, Inês A. Santos, Maria S. Bjork, James Moreno, António J. Wallace, Kendall B. Oliveira, Paulo J. |
Keywords: | Animals; Antibiotics, Antineoplastic; Cardiolipins; Cytochromes c; Doxorubicin; Kidney; Liver; Male; Mitochondria; Mitochondrial Myopathies; Myocardium; Rats, Wistar | Issue Date: | 2016 | Serial title, monograph or event: | Mitochondrion | Volume: | 30 | Abstract: | It is still unclear why anthracycline treatment results in a cardiac-specific myopathy. We investigated whether selective doxorubicin (DOX) cardiotoxicity involving mitochondrial degeneration is explained by different respiratory complexes reserves between tissues by comparing and contrasting treatment effects in heart vs liver and kidney. Alternatively, we have also explored if the degeneration is due to alterations of mitochondrial thresholds to incompatible states. | URI: | https://hdl.handle.net/10316/47559 | DOI: | 10.1016/j.mito.2016.07.005 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Pereira et al._2016_Mitochondrion_Cardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mito-annotated.pdf | 1.81 MB | Adobe PDF | View/Open |
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