Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/47559
DC FieldValueLanguage
dc.contributor.authorPereira, Gonçalo C.-
dc.contributor.authorPereira, Susana P.-
dc.contributor.authorTavares, Ludgero C.-
dc.contributor.authorCarvalho, Filipa S.-
dc.contributor.authorMagalhães-Novais, Sílvia-
dc.contributor.authorBarbosa, Inês A.-
dc.contributor.authorSantos, Maria S.-
dc.contributor.authorBjork, James-
dc.contributor.authorMoreno, António J.-
dc.contributor.authorWallace, Kendall B.-
dc.contributor.authorOliveira, Paulo J.-
dc.date.accessioned2018-02-12T13:38:23Z-
dc.date.available2018-02-12T13:38:23Z-
dc.date.issued2016-
dc.identifier.urihttp://hdl.handle.net/10316/47559-
dc.description.abstractIt is still unclear why anthracycline treatment results in a cardiac-specific myopathy. We investigated whether selective doxorubicin (DOX) cardiotoxicity involving mitochondrial degeneration is explained by different respiratory complexes reserves between tissues by comparing and contrasting treatment effects in heart vs liver and kidney. Alternatively, we have also explored if the degeneration is due to alterations of mitochondrial thresholds to incompatible states.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAnimalspor
dc.subjectAntibiotics, Antineoplasticpor
dc.subjectCardiolipinspor
dc.subjectCytochromes cpor
dc.subjectDoxorubicinpor
dc.subjectKidneypor
dc.subjectLiverpor
dc.subjectMalepor
dc.subjectMitochondriapor
dc.subjectMitochondrial Myopathiespor
dc.subjectMyocardiumpor
dc.subjectRats, Wistarpor
dc.titleCardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mitochondrial functionpor
dc.typearticle-
degois.publication.firstPage95-104por
degois.publication.lastPage104por
degois.publication.titleMitochondrionpor
dc.peerreviewedyespor
dc.identifier.doi10.1016/j.mito.2016.07.005por
degois.publication.volume30por
uc.controloAutoridadeSim-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptInstitute of Interdisciplinary Research-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitMARE - Marine and Environmental Sciences Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-1168-2444-
crisitem.author.orcid0000-0002-2324-1259-
crisitem.author.orcid0000-0002-6881-9392-
crisitem.author.orcid0000-0003-3575-7604-
crisitem.author.orcid0000-0002-5201-9948-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
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