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Title: Cardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mitochondrial function
Authors: Pereira, Gonçalo C
Pereira, Susana P
Tavares, Ludgero C
Carvalho, Filipa S
Magalhães-Novais, Silvia
Barbosa, Inês A
Santos, Maria S
Bjork, James
Moreno, António J
Wallace, Kendall B
Oliveira, Paulo J
Keywords: Animals
Antibiotics, Antineoplastic
Cytochromes c
Mitochondrial Myopathies
Rats, Wistar
Issue Date: 2016
Abstract: It is still unclear why anthracycline treatment results in a cardiac-specific myopathy. We investigated whether selective doxorubicin (DOX) cardiotoxicity involving mitochondrial degeneration is explained by different respiratory complexes reserves between tissues by comparing and contrasting treatment effects in heart vs liver and kidney. Alternatively, we have also explored if the degeneration is due to alterations of mitochondrial thresholds to incompatible states.
Peer review: yes
DOI: 10.1016/j.mito.2016.07.005
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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