Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/47559
Title: Cardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mitochondrial function
Authors: Pereira, Gonçalo C
Pereira, Susana P
Tavares, Ludgero C
Carvalho, Filipa S
Magalhães-Novais, Silvia
Barbosa, Inês A
Santos, Maria S
Bjork, James
Moreno, António J
Wallace, Kendall B
Oliveira, Paulo J
Keywords: Animals
Antibiotics, Antineoplastic
Cardiolipins
Cytochromes c
Doxorubicin
Kidney
Liver
Male
Mitochondria
Mitochondrial Myopathies
Myocardium
Rats, Wistar
Issue Date: 2016
Abstract: It is still unclear why anthracycline treatment results in a cardiac-specific myopathy. We investigated whether selective doxorubicin (DOX) cardiotoxicity involving mitochondrial degeneration is explained by different respiratory complexes reserves between tissues by comparing and contrasting treatment effects in heart vs liver and kidney. Alternatively, we have also explored if the degeneration is due to alterations of mitochondrial thresholds to incompatible states.
Peer review: yes
URI: http://hdl.handle.net/10316/47559
DOI: 10.1016/j.mito.2016.07.005
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais



FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.