Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/113379
Título: | Marine Macroalgae Polyphenols as Potential Neuroprotective Antioxidants in Neurodegenerative Diseases | Autor: | Lomartire, Silvia Gonçalves, Ana M. M. |
Palavras-chave: | marine polyphenols; seaweeds; antioxidant activity; neurodegenerative diseases; neuroprotective activity | Data: | 23-Abr-2023 | Editora: | MDPI | Projeto: | This work is financed by national funds through FCT—Foundation for Science and Technology, I.P., within the scope of the projects LA/P/0069/2020 granted to the Associate Laboratory ARNET, UIDB/04292/2020—granted to MARE—Marine and Environmental Sciences Centre and UIDP/50017/2020+UIDB/50017/2020 (by FCT/MTCES) granted to CESAM—Centre for Environmental and Marine Studies. This research was co-financed by the project AlgaMar4antivirus—Marine MacroalgaE for the prevention and treatment of ANTIviral diseases (Coronavirus SARS-CoV-2) (FA_07_2018_009), funded by the Blue Fund under Public Notice No. 7/2018—Scientific Research and Marine Technology. Silvia Lomartire thanks Foundation for Science and Technology (FCT) for the financial support granted through the doctoral grant 2021.05005.BD. Ana M. M. Gonçalves acknowledges University of Coimbra for the contract IT057-18-7253. | Título da revista, periódico, livro ou evento: | Marine Drugs | Volume: | 21 | Número: | 5 | Resumo: | Polyphenols are beneficial natural compounds with antioxidant properties that have recently gain a lot of interest for their potential therapeutic applications. Marine polyphenols derived from marine macroalgae have been discovered to possess interesting antioxidant properties; therefore, these compounds can be included in several areas of drug development. Authors have considered the use of polyphenol extracts from seaweeds as neuroprotective antioxidants in neurodegenerative diseases. Marine polyphenols may slow the progression and limit neuronal cell loss due to their antioxidant activity; therefore, the use of these natural compounds would improve the quality of life for patients affected with neurodegenerative diseases. Marine polyphenols have distinct characteristics and potential. Among seaweeds, brown algae are the main sources of polyphenols, and present the highest antioxidant activity in comparison to red algae and green algae. The present paper collects the most recent in vitro and in vivo evidence from investigations regarding polyphenols extracted from seaweeds that exhibit neuroprotective antioxidant activity. Throughout the review, oxidative stress in neurodegeneration and the mechanism of action of marine polyphenol antioxidant activity are discussed to evidence the potential of algal polyphenols for future use in drug development to delay cell loss in patients with neurodegenerative disorders. | URI: | https://hdl.handle.net/10316/113379 | ISSN: | 1660-3397 | DOI: | 10.3390/md21050261 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D MARE - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Marine-Macroalgae-Polyphenols-as-Potential-Neuroprotective-Antioxidants-in-Neurodegenerative-DiseasesMarine-Drugs.pdf | 1.37 MB | Adobe PDF | Ver/Abrir |
Visualizações de página
28
Visto em 8/mai/2024
Downloads
6
Visto em 8/mai/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons