Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/113276
Title: Pharmaceuticals in Coastal Waters: An UHPLC-TOF-MS Multi-Residue Approach
Authors: Leston, Sara 
Freitas, Andreia
Rosa, João 
Vila Pouca, Ana Sofia
Barbosa, Jorge
Reis-Santos, Patrick 
Fonseca, Vanessa F.
Pardal, Miguel 
Ramos, Fernando 
Keywords: environmental contamination; emerging contaminants; drugs; seawater; UHPLC-TOF-MS
Issue Date: 2023
Publisher: MDPI
Project: The authors would like to thank Fundação para a Ciência e a Tecnologia (FCT) for funding the research via project grants PTDC/MAR-EST/3048/2014 (BIOPHARMA), UIDB/04292/202, MARE (Marine and Environmental Sciences Centre, UIDB/04292/2020 and UIDP/04292/2020), ARNET (Aquatic Research Network Associated Laboratory, LA/P/0069/2020). and through the strategic plan of the Centre for Functional Ecology—Science for People and the Planet (CFE; UIDB/04004/2021), financed by FCT/MCTES through national funds (PIDDAC). Additional support was obtained via project “RENATURE—Valorization of the Natural Endogenous Resources of the Centro Region” (CENTRO-01-0145-FEDER-000007), funded by the Comissão de Coordenação da Região Centro. Sara Leston is supported by a researcher contract at the University of Coimbra (DL57/2016/IT057-18-7255). 
Serial title, monograph or event: Applied Sciences (Switzerland)
Volume: 13
Issue: 10
Abstract: Anthropogenic chemical contamination represents a key stressor of natural environments with pharmaceuticals comprising a particular group of emerging pollutants with the potential to induce biological responses in non-target organisms. Therefore, an analytical method based on ultra-high-performance liquid chromatography coupled to time-of-flight tandem mass spectrometry (UHPLC-TOF-MS) was developed for estuarine and seawaters, targeting 63 globally used pharmaceuticals (including amoxicillin, ciprofloxacin, sulfamethoxazole, trimethoprim and venlafaxine included in the SurfaceWaterWatch List) from 8 therapeutic groups: antibiotics, analgesic, NSAIDs, antidepressants, -blockers, lipid regulators, anticonvulsants and antihypertensive drugs. The method presents high selectivity and sensitivity, with the limits of detection ranging from 0.01 to 8.92 ng/L and the limits of quantification from 0.02 to 29.73 ng/L. Considering precision, the highest value was achieved for amoxicillin (20.9%) and the lower for ofloxacin (2.6%), while recoveries ranged from 80.6 to 112.6%. Overall, the quantification method was highly efficient for multi-residues quantification in such complex environmental samples.
URI: https://hdl.handle.net/10316/113276
ISSN: 2076-3417
DOI: 10.3390/app13105975
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
I&D MARE - Artigos em Revistas Internacionais
I&D CFE - Artigos em Revistas Internacionais

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