Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/113276
DC FieldValueLanguage
dc.contributor.authorLeston, Sara-
dc.contributor.authorFreitas, Andreia-
dc.contributor.authorRosa, João-
dc.contributor.authorVila Pouca, Ana Sofia-
dc.contributor.authorBarbosa, Jorge-
dc.contributor.authorReis-Santos, Patrick-
dc.contributor.authorFonseca, Vanessa F.-
dc.contributor.authorPardal, Miguel-
dc.contributor.authorRamos, Fernando-
dc.date.accessioned2024-02-12T14:19:05Z-
dc.date.available2024-02-12T14:19:05Z-
dc.date.issued2023-
dc.identifier.issn2076-3417pt
dc.identifier.urihttps://hdl.handle.net/10316/113276-
dc.description.abstractAnthropogenic chemical contamination represents a key stressor of natural environments with pharmaceuticals comprising a particular group of emerging pollutants with the potential to induce biological responses in non-target organisms. Therefore, an analytical method based on ultra-high-performance liquid chromatography coupled to time-of-flight tandem mass spectrometry (UHPLC-TOF-MS) was developed for estuarine and seawaters, targeting 63 globally used pharmaceuticals (including amoxicillin, ciprofloxacin, sulfamethoxazole, trimethoprim and venlafaxine included in the SurfaceWaterWatch List) from 8 therapeutic groups: antibiotics, analgesic, NSAIDs, antidepressants, -blockers, lipid regulators, anticonvulsants and antihypertensive drugs. The method presents high selectivity and sensitivity, with the limits of detection ranging from 0.01 to 8.92 ng/L and the limits of quantification from 0.02 to 29.73 ng/L. Considering precision, the highest value was achieved for amoxicillin (20.9%) and the lower for ofloxacin (2.6%), while recoveries ranged from 80.6 to 112.6%. Overall, the quantification method was highly efficient for multi-residues quantification in such complex environmental samples.pt
dc.language.isoengpt
dc.publisherMDPIpt
dc.relationThe authors would like to thank Fundação para a Ciência e a Tecnologia (FCT) for funding the research via project grants PTDC/MAR-EST/3048/2014 (BIOPHARMA), UIDB/04292/202, MARE (Marine and Environmental Sciences Centre, UIDB/04292/2020 and UIDP/04292/2020), ARNET (Aquatic Research Network Associated Laboratory, LA/P/0069/2020). and through the strategic plan of the Centre for Functional Ecology—Science for People and the Planet (CFE; UIDB/04004/2021), financed by FCT/MCTES through national funds (PIDDAC). Additional support was obtained via project “RENATURE—Valorization of the Natural Endogenous Resources of the Centro Region” (CENTRO-01-0145-FEDER-000007), funded by the Comissão de Coordenação da Região Centro. Sara Leston is supported by a researcher contract at the University of Coimbra (DL57/2016/IT057-18-7255).pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectenvironmental contaminationpt
dc.subjectemerging contaminantspt
dc.subjectdrugspt
dc.subjectseawaterpt
dc.subjectUHPLC-TOF-MSpt
dc.titlePharmaceuticals in Coastal Waters: An UHPLC-TOF-MS Multi-Residue Approachpt
dc.typearticle-
degois.publication.firstPage5975pt
degois.publication.issue10pt
degois.publication.titleApplied Sciences (Switzerland)pt
dc.peerreviewedyespt
dc.identifier.doi10.3390/app13105975pt
degois.publication.volume13pt
dc.date.embargo2023-01-01*
uc.date.periodoEmbargo0pt
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.cerifentitytypePublications-
crisitem.author.researchunitCFE - Centre for Functional Ecology - Science for People & the Planet-
crisitem.author.researchunitMARE - Marine and Environmental Sciences Centre-
crisitem.author.researchunitCFE - Centre for Functional Ecology - Science for People & the Planet-
crisitem.author.orcid0000-0001-9843-9465-
crisitem.author.orcid0000-0001-6048-7007-
crisitem.author.orcid0000-0002-6043-819X-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
I&D MARE - Artigos em Revistas Internacionais
I&D CFE - Artigos em Revistas Internacionais
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