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Credit Name
Cunha-Oliveira, Teresa
 
Name
Cunha-Oliveira, Teresa
 
Variants
Oliveira, M.T.
Cunha-Oliveira, T.
Oliveira, T.C.
 
Email
teresa.oliveira@uc-biotech.pt
 
 
 
Scopus Author ID
 
Researcher ID
 
Status
UC Researcher
Biography
Teresa Cunha-Oliveira got her PhD in Biology (Cell Biology) in 2007 from the University of Coimbra (Portugal), having contributed to introduce the role of mitochondria in the field of drug addiction, particularly concerning cocaine, heroin and amphetamine. In her first post-doctoral period (2007-2010) in the Center for Neuroscience and Cell Biology (CNC, Coimbra), she collaborated with a Medicinal Chemistry group at the University of Porto to uncover the cellular effects of a newly found chemical interaction between heroin and cocaine (speedball) that could have a great impact in the understanding of poly-drug abuse consequences. In her second post-doctoral period (2010-2012), she was focused on the role of mitochondria in neurodegenerative diseases, including Huntington’s disease (HD) and Parkinson’s disease. She became interested in the epigenetic mechanisms associated with long-term mitochondrial dysfunction and contributed to characterize the bioenergetic dysfunction in cybrids from HD patients, evidencing the involvement of pyruvate dehydrogenase (PDH) and the promising role of epigenetic modulators in reversing PDH and mitochondrial dysfunctions in HD models. From 2013 until now, she is part of the MitoXT group at the CNC, more interested in the role of mitochondria in drug toxicology and experimental therapeutics, especially doxorubicin (DOX), an anticancer agent with long-term cardiotoxic side-effects involving mitochondria. She contributed to describe DOX-induced mitochondrial dysfunction, transcriptional deregulation and epigenetic signalling using in vitro and in vivo models. Her current interests include the development and validation of innovative screening assays to assess mitochondrial health with applications in toxicology, diagnostics and development of innovative therapeutic strategies for personalized medicine.
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Publications
(All)

Refined By:
Subject:  Mitochondria

Results 1-11 of 11 (Search time: 0.009 seconds).

Issue DateTitleAuthor(s)TypeAccess
1Feb-2015Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human LymphoblastsNaia, Luana ; Ferreira, I. Luísa ; Cunha-Oliveira, Teresa ; Duarte, Ana I. ; Ribeiro, Márcio ; Rosenstock, Tatiana R. ; Laço, Mário N. ; Ribeiro, Maria J. ; Oliveira, Catarina R. ; Saudou, Frédéric ; Humbert, Sandrine ; Rego, A. Cristina articleopenAccess
22013Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondriaCunha-Oliveira, Teresa ; Silva, Lisbeth ; Silva, Ana Maria ; Moreno, António J. ; Oliveira, Catarina R. ; Santos, Maria S. articleopenAccess
32015Analysis of pro-apoptotic protein trafficking to and from mitochondriaVega-Naredo, Ignacio ; Cunha-Oliveira, Teresa ; Serafim, Teresa L. ; Sardão, Vilma A. ; Oliveira, Paulo J. articleopenAccess
48-Mar-2017Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's DiseaseNaia, Luana ; Cunha-Oliveira, Teresa ; Rodrigues, Joana ; Rosenstock, Tatiana R. ; Oliveira, Ana ; Ribeiro, Márcio ; Carmo, Catarina ; Oliveira-Sousa, Sofia I. ; Duarte, Ana I. ; Hayden, Michael R. ; Rego, A. Cristina articleopenAccess
52021A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patientsDeus, Cláudia M. ; Pereira, Susana P.; Cunha-Oliveira, Teresa ; Teixeira, José; Simões, Rui F. ; Cagide, Fernando; Benfeito, Sofia; Borges, Fernanda; Raimundo, Nuno ; Oliveira, Paulo J.articleopenAccess
6Dec-2014Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblastsMoreira, Ana C. ; Branco, Ana F. ; Sampaio, Susana F. ; Cunha-Oliveira, Teresa ; Martins, Tatiana R. ; Holy, Jon ; Oliveira, Paulo J. ; Sardão, Vilma A. articleopenAccess
72020Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defectsDeus, Cláudia M. ; Pereira, Susana P. ; Cunha-Oliveira, Teresa ; Pereira, Francisco B. ; Raimundo, Nuno Filipe Viegas das Neves ; Oliveira, Paulo J. articleembargoedAccess
82021Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamineSimões, Rui F. ; Pino, Rute; Soares, Maurício Moreira ; Kovarova, Jaromira ; Neuzil, Jiri ; Travasso, Rui ; Oliveira, Paulo J.; Cunha-Oliveira, Teresa ; Pereira, Francisco B.articleopenAccess
9Sep-2013Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abusePerfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina articleopenAccess
10Jan-2015Role of mtDNA-related mitoepigenetic phenomena in cancerFerreira, André ; Serafim, Teresa L. ; Sardão, Vilma A. ; Cunha-Oliveira, Teresa articleopenAccess
112014β-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?Branco, Ana F. ; Moreira, Ana C. ; Cunha-Oliveira, Teresa ; Couto, Renata ; Sardão, Vilma A. ; Rizvanov, Albert A. ; Palotas, Andras ; Oliveira, Paulo J. articleopenAccess