Cunha-Oliveira, Teresa
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Credit Name
Cunha-Oliveira, Teresa
Name
Cunha-Oliveira, Teresa
Variants
Oliveira, M.T.
Cunha-Oliveira, T.
Oliveira, T.C.
Cunha-Oliveira, T.
Oliveira, T.C.
Email
teresa.oliveira@uc-biotech.pt
Other emails
https://orcid.org/0000-0002-7382-0339
Scopus Author ID
Researcher ID
Status
UC Researcher
Biography
Teresa Cunha-Oliveira got her PhD in Biology (Cell Biology) in 2007 from the University of Coimbra (Portugal), having contributed to introduce the role of mitochondria in the field of drug addiction, particularly concerning cocaine, heroin and amphetamine. In her first post-doctoral period (2007-2010) in the Center for Neuroscience and Cell Biology (CNC, Coimbra), she collaborated with a Medicinal Chemistry group at the University of Porto to uncover the cellular effects of a newly found chemical interaction between heroin and cocaine (speedball) that could have a great impact in the understanding of poly-drug abuse consequences. In her second post-doctoral period (2010-2012), she was focused on the role of mitochondria in neurodegenerative diseases, including Huntington’s disease (HD) and Parkinson’s disease. She became interested in the epigenetic mechanisms associated with long-term mitochondrial dysfunction and contributed to characterize the bioenergetic dysfunction in cybrids from HD patients, evidencing the involvement of pyruvate dehydrogenase (PDH) and the promising role of epigenetic modulators in reversing PDH and mitochondrial dysfunctions in HD models. From 2013 until now, she is part of the MitoXT group at the CNC, more interested in the role of mitochondria in drug toxicology and experimental therapeutics, especially doxorubicin (DOX), an anticancer agent with long-term cardiotoxic side-effects involving mitochondria. She contributed to describe DOX-induced mitochondrial dysfunction, transcriptional deregulation and epigenetic signalling using in vitro and in vivo models. Her current interests include the development and validation of innovative screening assays to assess mitochondrial health with applications in toxicology, diagnostics and development of innovative therapeutic strategies for personalized medicine.
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Publications
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Results 1-26 of 26 (Search time: 0.034 seconds).
| Issue Date | Title | Author(s) | Type | Access | |
|---|---|---|---|---|---|
| 1 | Feb-2015 | Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts | Naia, Luana ; Ferreira, I. Luísa ; Cunha-Oliveira, Teresa ; Duarte, Ana I. ; Ribeiro, Márcio ; Rosenstock, Tatiana R. ; Laço, Mário N. ; Ribeiro, Maria J. ; Oliveira, Catarina R. ; Saudou, Frédéric ; Humbert, Sandrine ; Rego, A. Cristina | article | openAccess |
| 2 | 2007 | Adaptation to oxidative stress in the chronic effects of cocaine and amphetamine | Cunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. | article | openAccess |
| 3 | 2009 | BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons | Almeida, S. ; Laço, M. ; Cunha-Oliveira, T. ; Oliveira, C. R. ; Rego, A. C. | article | openAccess |
| 4 | Sep-2011 | Bioenergetic dysfunction in Huntington's disease human cybrids | Ferreira, I. Luísa ; Cunha-Oliveira, Teresa ; Nascimento, Maria V. ; Ribeiro, Márcio ; Proença, M. Teresa ; Januário, Cristina ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 5 | 2008 | Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs | Cunha-Oliveira, Teresa ; Rego, Ana Cristina ; Oliveira, Catarina R. | article | openAccess |
| 6 | Feb-2012 | Consequences of mitochondrial dysfunction in Huntington's Disease and protection via phosphorylation pathways | Cunha-Oliveira, Teresa ; Ferreira, Ildete L. ; Rego, A. Cristina | bookPart | openAccess |
| 7 | 2005 | Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide | Cunha-Oliveira, T. ; Rego, A. C. ; Morgadinho, M. T. ; Sarmento, A. ; Macedo, T. ; Oliveira, C. R. | conferenceObject | openAccess |
| 8 | 2006 | Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Morgadinho, Maria Teresa ; Macedo, Tice ; Oliveira, Catarina Resende | article | openAccess |
| 9 | Sep-2012 | Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice | Pereira, Frederico ; Cunha-Oliveira, Teresa ; Viana, Sofia ; Travassos, Ana Sofia ; Nunes, Sara ; Silva, Carlos ; Prediger, Rui ; Rego, Ana Cristina ; Ali, Syed ; Fontes Ribeiro, Carlos Alberto | article | closedAccess |
| 10 | 2009 | Dysregulation of CREB Activation and Histone Acetylation in 3-Nitropropionic Acid-Treated Cortical Neurons: Prevention by BDNF and NGF | Almeida, Sandra ; Cunha-Oliveira, Teresa ; Laço, Mário ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 11 | 9-Mar-2012 | Efeito crónico da heroína e do peróxido de hidrogénio em células PC12 | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Morgadinho, M. Teresa ; Macedo, Tice R. ; Oliveira, Catarina R. | article | openAccess |
| 12 | 8-Mar-2012 | Expression of NR1/NR2B N-Methyl-d-Aspartate Receptors Enhances Heroin Toxicity in HEK293 Cells | Domingues, António ; Cunha-Oliveira, Teresa ; Laço, Mário L. N. ; Macedo, Tice ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 13 | 15-Nov-2012 | Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells | Ribeiro, Márcio ; Rosenstock, Tatiana ; Cunha-Oliveira, Teresa ; Ferreira, Ildete ; Oliveira, Catarina R. ; Rego, Ana Cristina | article | openAccess |
| 14 | 2005 | Heroin-induced degeneration of cortical neurons involves mitochondria-dependent apoptosis | Cunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. | article | openAccess |
| 15 | 8-Mar-2017 | Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease | Naia, Luana ; Cunha-Oliveira, Teresa ; Rodrigues, Joana ; Rosenstock, Tatiana R. ; Oliveira, Ana ; Ribeiro, Márcio ; Carmo, Catarina ; Oliveira-Sousa, Sofia I. ; Duarte, Ana I. ; Hayden, Michael R. ; Rego, A. Cristina | article | openAccess |
| 16 | 2013 | Medical Toxicology of Drugs of Abuse | Cunha-Oliveira, Teresa ; Rego, Ana Cristina ; Carvalho, Félix ; Oliveira, Catarina R. | bookPart | openAccess |
| 17 | 2006 | Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine | Cunha-Oliveira, T. ; Rego, A. C. ; Cardoso, S. M. ; Borges, F. ; Swerdlow, R. ; Macedo, T. ; Oliveira, C. R. | article | openAccess |
| 18 | 2011 | Molecular interaction between cocaine and opioids. Implications on Speedball's toxicity | Cunha-Oliveira, T. ; Silva, L. ; Silva, A. M. ; Santos, M. S. ; Garrido, J. ; Borges, F. ; Rego, A. C. ; Oliveira, C. R. | conferenceObject | openAccess |
| 19 | 2021 | MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile | Jacinto, Sandra; Guerreiro, Patrícia; Oliveira, Rita Machado de; Oliveira, Teresa Cunha ; Santos, Maria João ; Grazina, Manuela ; Rego, A. Cristina ; Outeiro, Tiago F. | article | openAccess |
| 20 | 2012 | Neurotoxicity of cocaine | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. | bookPart | openAccess |
| 21 | 8-Mar-2012 | Neurotoxicity of heroin-cocaine combinations in rat cortical neurons | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina R. | article | openAccess |
| 22 | 28-Aug-2014 | Oxidative Stress and Drugs of Abuse: An Update | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. | article | openAccess |
| 23 | Sep-2013 | Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse | Perfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina | article | openAccess |
| 24 | 1-Nov-2012 | Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse | Perfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina | article | openAccess |
| 25 | 2007 | Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina Resende | article | openAccess |
| 26 | Oct-2006 | Synthesis and Cytotoxic Profile of 3,4-Methylenedioxymethamphetamine (“Ecstasy”) and Its Metabolites on Undifferentiated PC12 Cells: A Putative Structure−Toxicity Relationship | Milhazes, Nuno ; Cunha-Oliveira, Teresa ; Martins, Pedro ; Garrido, Jorge ; Oliveira, Catarina ; Rego, A. Cristina ; Borges, Fernanda | article | openAccess |