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Credit Name
Cunha-Oliveira, Teresa
 
Name
Cunha-Oliveira, Teresa
 
Variants
Oliveira, M.T.
Cunha-Oliveira, T.
Oliveira, T.C.
 
Email
teresa.oliveira@uc-biotech.pt
 
 
 
Scopus Author ID
 
Researcher ID
 
Status
UC Researcher
Biography
Teresa Cunha-Oliveira got her PhD in Biology (Cell Biology) in 2007 from the University of Coimbra (Portugal), having contributed to introduce the role of mitochondria in the field of drug addiction, particularly concerning cocaine, heroin and amphetamine. In her first post-doctoral period (2007-2010) in the Center for Neuroscience and Cell Biology (CNC, Coimbra), she collaborated with a Medicinal Chemistry group at the University of Porto to uncover the cellular effects of a newly found chemical interaction between heroin and cocaine (speedball) that could have a great impact in the understanding of poly-drug abuse consequences. In her second post-doctoral period (2010-2012), she was focused on the role of mitochondria in neurodegenerative diseases, including Huntington’s disease (HD) and Parkinson’s disease. She became interested in the epigenetic mechanisms associated with long-term mitochondrial dysfunction and contributed to characterize the bioenergetic dysfunction in cybrids from HD patients, evidencing the involvement of pyruvate dehydrogenase (PDH) and the promising role of epigenetic modulators in reversing PDH and mitochondrial dysfunctions in HD models. From 2013 until now, she is part of the MitoXT group at the CNC, more interested in the role of mitochondria in drug toxicology and experimental therapeutics, especially doxorubicin (DOX), an anticancer agent with long-term cardiotoxic side-effects involving mitochondria. She contributed to describe DOX-induced mitochondrial dysfunction, transcriptional deregulation and epigenetic signalling using in vitro and in vivo models. Her current interests include the development and validation of innovative screening assays to assess mitochondrial health with applications in toxicology, diagnostics and development of innovative therapeutic strategies for personalized medicine.
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Publications
(All)

Refined By:
Author:  Rego, Ana Cristina

Results 1-26 of 26 (Search time: 0.02 seconds).

Issue DateTitleAuthor(s)TypeAccess
1Feb-2015Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human LymphoblastsNaia, Luana ; Ferreira, I. Luísa ; Cunha-Oliveira, Teresa ; Duarte, Ana I. ; Ribeiro, Márcio ; Rosenstock, Tatiana R. ; Laço, Mário N. ; Ribeiro, Maria J. ; Oliveira, Catarina R. ; Saudou, Frédéric ; Humbert, Sandrine ; Rego, A. Cristina articleopenAccess
22007Adaptation to oxidative stress in the chronic effects of cocaine and amphetamineCunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. articleopenAccess
32009BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neuronsAlmeida, S. ; Laço, M. ; Cunha-Oliveira, T. ; Oliveira, C. R. ; Rego, A. C. articleopenAccess
4Sep-2011Bioenergetic dysfunction in Huntington's disease human cybridsFerreira, I. Luísa ; Cunha-Oliveira, Teresa ; Nascimento, Maria V. ; Ribeiro, Márcio ; Proença, M. Teresa ; Januário, Cristina ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
52008Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugsCunha-Oliveira, Teresa ; Rego, Ana Cristina ; Oliveira, Catarina R. articleopenAccess
6Feb-2012Consequences of mitochondrial dysfunction in Huntington's Disease and protection via phosphorylation pathwaysCunha-Oliveira, Teresa ; Ferreira, Ildete L. ; Rego, A. Cristina bookPartopenAccess
72005Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxideCunha-Oliveira, T. ; Rego, A. C. ; Morgadinho, M. T. ; Sarmento, A. ; Macedo, T. ; Oliveira, C. R. conferenceObjectopenAccess
82006Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxideCunha-Oliveira, Teresa ; Rego, A. Cristina ; Morgadinho, Maria Teresa ; Macedo, Tice ; Oliveira, Catarina Resende articleopenAccess
9Sep-2012Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in micePereira, Frederico ; Cunha-Oliveira, Teresa ; Viana, Sofia ; Travassos, Ana Sofia ; Nunes, Sara ; Silva, Carlos ; Prediger, Rui ; Rego, Ana Cristina ; Ali, Syed ; Fontes Ribeiro, Carlos Alberto articleclosedAccess
102009Dysregulation of CREB Activation and Histone Acetylation in 3-Nitropropionic Acid-Treated Cortical Neurons: Prevention by BDNF and NGFAlmeida, Sandra ; Cunha-Oliveira, Teresa ; Laço, Mário ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
119-Mar-2012Efeito crónico da heroína e do peróxido de hidrogénio em células PC12Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Morgadinho, M. Teresa ; Macedo, Tice R. ; Oliveira, Catarina R. articleopenAccess
128-Mar-2012Expression of NR1/NR2B N-Methyl-d-Aspartate Receptors Enhances Heroin Toxicity in HEK293 CellsDomingues, António ; Cunha-Oliveira, Teresa ; Laço, Mário L. N. ; Macedo, Tice ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
1315-Nov-2012Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cellsRibeiro, Márcio ; Rosenstock, Tatiana ; Cunha-Oliveira, Teresa ; Ferreira, Ildete ; Oliveira, Catarina R. ; Rego, Ana Cristina articleopenAccess
142005Heroin-induced degeneration of cortical neurons involves mitochondria-dependent apoptosisCunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. articleopenAccess
158-Mar-2017Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's DiseaseNaia, Luana ; Cunha-Oliveira, Teresa ; Rodrigues, Joana ; Rosenstock, Tatiana R. ; Oliveira, Ana ; Ribeiro, Márcio ; Carmo, Catarina ; Oliveira-Sousa, Sofia I. ; Duarte, Ana I. ; Hayden, Michael R. ; Rego, A. Cristina articleopenAccess
162013Medical Toxicology of Drugs of AbuseCunha-Oliveira, Teresa ; Rego, Ana Cristina ; Carvalho, Félix ; Oliveira, Catarina R. bookPartopenAccess
172006Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamineCunha-Oliveira, T. ; Rego, A. C. ; Cardoso, S. M. ; Borges, F. ; Swerdlow, R. ; Macedo, T. ; Oliveira, C. R. articleopenAccess
182011Molecular interaction between cocaine and opioids. Implications on Speedball's toxicityCunha-Oliveira, T. ; Silva, L. ; Silva, A. M. ; Santos, M. S. ; Garrido, J. ; Borges, F. ; Rego, A. C. ; Oliveira, C. R. conferenceObjectopenAccess
192021MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic ProfileJacinto, Sandra; Guerreiro, Patrícia; Oliveira, Rita Machado de; Oliveira, Teresa Cunha ; Santos, Maria João ; Grazina, Manuela ; Rego, A. Cristina ; Outeiro, Tiago F. articleopenAccess
202012Neurotoxicity of cocaineCunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. bookPartopenAccess
218-Mar-2012Neurotoxicity of heroin-cocaine combinations in rat cortical neuronsCunha-Oliveira, Teresa ; Rego, A. Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina R. articleopenAccess
2228-Aug-2014Oxidative Stress and Drugs of Abuse: An UpdateCunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. articleopenAccess
23Sep-2013Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abusePerfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina articleopenAccess
241-Nov-2012Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abusePerfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina articleopenAccess
252007Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neuronsCunha-Oliveira, Teresa ; Rego, A. Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina Resende articleopenAccess
26Oct-2006Synthesis and Cytotoxic Profile of 3,4-Methylenedioxymethamphetamine (“Ecstasy”) and Its Metabolites on Undifferentiated PC12 Cells: A Putative Structure−Toxicity RelationshipMilhazes, Nuno ; Cunha-Oliveira, Teresa ; Martins, Pedro ; Garrido, Jorge ; Oliveira, Catarina ; Rego, A. Cristina ; Borges, Fernanda articleopenAccess