Cunha-Oliveira, Teresa

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Credit Name
Cunha-Oliveira, Teresa
 
Name
Cunha-Oliveira, Teresa
 
Variants
Oliveira, M.T.
Cunha-Oliveira, T.
Oliveira, T.C.
 
Email
teresa.oliveira@uc-biotech.pt
 
Other emails
 
ORCID
 
Scopus Author ID
 
Researcher ID
 
Status
UC Researcher
Biography
Teresa Cunha-Oliveira got her PhD in Biology (Cell Biology) in 2007 from the University of Coimbra (Portugal), having contributed to introduce the role of mitochondria in the field of drug addiction, particularly concerning cocaine, heroin and amphetamine. In her first post-doctoral period (2007-2010) in the Center for Neuroscience and Cell Biology (CNC, Coimbra), she collaborated with a Medicinal Chemistry group at the University of Porto to uncover the cellular effects of a newly found chemical interaction between heroin and cocaine (speedball) that could have a great impact in the understanding of poly-drug abuse consequences. In her second post-doctoral period (2010-2012), she was focused on the role of mitochondria in neurodegenerative diseases, including Huntington’s disease (HD) and Parkinson’s disease. She became interested in the epigenetic mechanisms associated with long-term mitochondrial dysfunction and contributed to characterize the bioenergetic dysfunction in cybrids from HD patients, evidencing the involvement of pyruvate dehydrogenase (PDH) and the promising role of epigenetic modulators in reversing PDH and mitochondrial dysfunctions in HD models. From 2013 until now, she is part of the MitoXT group at the CNC, more interested in the role of mitochondria in drug toxicology and experimental therapeutics, especially doxorubicin (DOX), an anticancer agent with long-term cardiotoxic side-effects involving mitochondria. She contributed to describe DOX-induced mitochondrial dysfunction, transcriptional deregulation and epigenetic signalling using in vitro and in vivo models. Her current interests include the development and validation of innovative screening assays to assess mitochondrial health with applications in toxicology, diagnostics and development of innovative therapeutic strategies for personalized medicine.
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Publications
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Type:  article
Author:  Simões, Rui F.

Results 1-9 of 9 (Search time: 0.008 seconds).

Issue DateTitleAuthor(s)TypeAccess
11-Sep-2017Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicityFerreira, André ; Cunha-Oliveira, Teresa ; Simões, Rui F. ; Carvalho, Filipa S. ; Burgeiro, Ana ; Nordgren, Kendra ; Wallace, Kendall B. ; Oliveira, Paulo J. articleopenAccess
2Nov-2017Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblastsCoelho, Ana R. ; Martins, Tatiana R. ; Couto, Renata ; Deus, Cláudia ; Pereira, Cláudia V. ; Simões, Rui F. ; Rizvanov, Albert A. ; Silva, Filomena ; Cunha-Oliveira, Teresa ; Oliveira, Paulo J. ; Serafim, Teresa L. articleopenAccess
3Nov-2021Corrigendum to 'A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients'. [Redox Biology 45 (2021) 102037]Deus, Cláudia M. ; Pereira, Susana P. ; Cunha-Oliveira, Teresa ; Teixeira, José ; Simões, Rui F. ; Cagide, Fernando; Benfeito, Sofia; Borges, Fernanda; Raimundo, Nuno ; Oliveira, Paulo J. articleopenAccess
410-Mar-2022Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational StatisticsSimões, Rui F. ; Oliveira, Paulo J. ; Oliveira, Teresa Cunha ; Pereira, Francisco B. articleopenAccess
518-Sep-2019Intracellular and Intercellular Mitochondrial Dynamics in Parkinson's DiseaseValdinocci, Dario; Simões, Rui F. ; Kovarova, Jaromira ; Cunha-Oliveira, Teresa ; Neuzil, Jiri ; Pountney, Dean LarticleopenAccess
6Mar-2016Ketogenic diets: from cancer to mitochondrial diseases and beyondBranco, Ana F. ; Ferreira, André ; Simões, Rui F. ; Magalhães-Novais, Sílvia ; Zehowski, Cheryl ; Cope, Elisabeth ; Silva, Ana Marta ; Pereira, Daniela ; Sardão, Vilma A. ; Cunha-Oliveira, Teresa articleopenAccess
716-Jul-2022Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systemsAmorim, Ricardo ; Simões, Inês C. M.; Teixeira, José; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana ; Tavares, Ludgero C. ; Benfeito, Sofia; Pereira, Susana P.; Simões, Rui F. ; Karkucinska-Wieckowska, Agnieszka; Viegas, Ivan ; Szymanska, Sylwia; Dąbrowski, Michał; Janikiewicz, Justyna; Cunha-Oliveira, Teresa ; Dobrzyń, Agnieszka; Jones, John Griffith ; Borges, Fernanda; Wieckowski, Mariusz R. ; Oliveira, Paulo J.articleopenAccess
82021A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patientsDeus, Cláudia M. ; Pereira, Susana P.; Cunha-Oliveira, Teresa ; Teixeira, José; Simões, Rui F. ; Cagide, Fernando; Benfeito, Sofia; Borges, Fernanda; Raimundo, Nuno ; Oliveira, Paulo J.articleopenAccess
92021Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamineSimões, Rui F. ; Pino, Rute; Soares, Maurício Moreira ; Kovarova, Jaromira ; Neuzil, Jiri ; Travasso, Rui ; Oliveira, Paulo J.; Cunha-Oliveira, Teresa ; Pereira, Francisco B.articleopenAccess