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Title: | Antioxidant Versus Cytotoxic Properties of Hydroxycinnamic Acid Derivatives - A New Paradigm in Phenolic Research | Authors: | Esteves, Mário Siquet, Christophe Gaspar, Alexandra Rio, Vitor Sousa, Joana B. Reis, Salette Marques, M. Paula M. Borges, Fernanda |
Keywords: | Antineoplastic Agents; Coumaric Acids; Female; Free Radical Scavengers; Free Radicals; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Liposomes; Oxidative Stress; Structure-Activity Relationship; Uterine Cervical Neoplasms | Issue Date: | 2008 | Citation: | Archiv der Pharmazie. 341:3 (2008) 164-173 | Serial title, monograph or event: | Archiv der Pharmazie | Volume: | 341 | Issue: | 3 | Abstract: | Trihydroxycinnamic derivatives were synthesized and evaluated for their antioxidant and cytotoxic activities. The ester derivatives exhibited a higher radical-scavenging activity, when liposomes were used as target systems, a fact which may be related to their lipophilicity and conformational preferences. These compounds were found to display significant growth inhibition and cytotoxic effects towards a human cervix adenocarcinoma cell line (HeLa). The partition coefficients presently obtained for the trihydroxycinnamic derivatives correlate well both with their structural characteristics and with their antioxidant/cytotoxic activities. A positive structure-activity-property relationship between cytotoxic and antioxidant activities, which is intrinsically related with physico-chemical and conformational properties, is anticipated, as a noteworthy study that must be done for phenolic systems. As damage events are frequently correlated with oxidative stress, the prevalence of both properties in a single compound could be beneficial in terms of rationale preventive or therapeutic purposes. | URI: | https://hdl.handle.net/10316/8108 | DOI: | 10.1002/ardp.200700168 | Rights: | openAccess |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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