Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/8108
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Esteves, Mário | - |
dc.contributor.author | Siquet, Christophe | - |
dc.contributor.author | Gaspar, Alexandra | - |
dc.contributor.author | Rio, Vitor | - |
dc.contributor.author | Sousa, Joana B. | - |
dc.contributor.author | Reis, Salette | - |
dc.contributor.author | Marques, M. Paula M. | - |
dc.contributor.author | Borges, Fernanda | - |
dc.date.accessioned | 2009-02-09T11:11:19Z | - |
dc.date.available | 2009-02-09T11:11:19Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Archiv der Pharmazie. 341:3 (2008) 164-173 | - |
dc.identifier.uri | https://hdl.handle.net/10316/8108 | - |
dc.description.abstract | Trihydroxycinnamic derivatives were synthesized and evaluated for their antioxidant and cytotoxic activities. The ester derivatives exhibited a higher radical-scavenging activity, when liposomes were used as target systems, a fact which may be related to their lipophilicity and conformational preferences. These compounds were found to display significant growth inhibition and cytotoxic effects towards a human cervix adenocarcinoma cell line (HeLa). The partition coefficients presently obtained for the trihydroxycinnamic derivatives correlate well both with their structural characteristics and with their antioxidant/cytotoxic activities. A positive structure-activity-property relationship between cytotoxic and antioxidant activities, which is intrinsically related with physico-chemical and conformational properties, is anticipated, as a noteworthy study that must be done for phenolic systems. As damage events are frequently correlated with oxidative stress, the prevalence of both properties in a single compound could be beneficial in terms of rationale preventive or therapeutic purposes. | - |
dc.language.iso | eng | - |
dc.rights | openAccess | - |
dc.subject | Antineoplastic Agents | - |
dc.subject | Coumaric Acids | - |
dc.subject | Female | - |
dc.subject | Free Radical Scavengers | - |
dc.subject | Free Radicals | - |
dc.subject | HeLa Cells | - |
dc.subject | Humans | - |
dc.subject | Hydrophobic and Hydrophilic Interactions | - |
dc.subject | Liposomes | - |
dc.subject | Oxidative Stress | - |
dc.subject | Structure-Activity Relationship | - |
dc.subject | Uterine Cervical Neoplasms | - |
dc.title | Antioxidant Versus Cytotoxic Properties of Hydroxycinnamic Acid Derivatives - A New Paradigm in Phenolic Research | - |
dc.type | article | - |
degois.publication.firstPage | 164 | - |
degois.publication.lastPage | 173 | - |
degois.publication.issue | 3 | - |
degois.publication.title | Archiv der Pharmazie | - |
dc.peerreviewed | yes | - |
dc.identifier.doi | 10.1002/ardp.200700168 | - |
degois.publication.volume | 341 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | QFM-UC – Molecular Physical-Chemistry R&D Unit | - |
crisitem.author.orcid | 0000-0002-8391-0055 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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