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https://hdl.handle.net/10316/21646
Título: | A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug | Autor: | Natu, Mădălina V. Gaspar, Manuel N. Ribeiro, Carlos A. Fontes Correia, Ilídio J. Silva, Daniela Sousa, Hermínio C. de Gil, M. H. |
Data: | 2011 | Editora: | IOP Publishing | Citação: | NATU, Mădălina V. [et al.] - A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug. "Biomedical Materials". ISSN 1748-60416. 6:2 (2011) 9 p. | Título da revista, periódico, livro ou evento: | Biomedical Materials | Volume: | 6 | Número: | 2 | Resumo: | Implantable dorzolamide-loaded discs were prepared by blending poly(ε-caprolactone), PCL, with poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), Lu. By blending, crystallinity, water uptake and mass loss were modified relative to the pure polymers. Burst was diminished by coating the discs with a PCL shell. All samples presented burst release except PCL-coated samples that showed controlled release during 18 days. For PCL-coated samples, barrier control of diffusion coupled with partition control from the core slowed down the release, while for 50/50 Lu/PCL-coated samples, the enhancement in the porosity of the core diminished partition control of drug release. Nonlinear regression analysis suggested that a degradation model fully describes the release curve considering a triphasic release mechanism: the instantaneous diffusion (burst), diffusion and polymer degradation stages. The MTT test indicated that the materials are not cytotoxic for corneal endothelial cells. A good in vitro–in vivo correlation was obtained, with similar amounts of drug released in vitro and in vivo. The discs decreased intraocular pressure (IOP) in normotensive rabbit eyes by 13.0% during 10 days for PCL-coated and by 13.0% during 4 days for 50/50 Lu/PCL-coated samples. The percentages of IOP decrease are similar to those obtained by dorzolamide eyedrop instillation (11.0%). | URI: | https://hdl.handle.net/10316/21646 | ISSN: | 1748-6041 | DOI: | 10.1088/1748-6041/6/2/025003 | Direitos: | closedAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais FCTUC Eng.Química - Artigos em Revistas Internacionais |
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2011 BM Natu.pdf | 650.21 kB | Adobe PDF | Pedir uma cópia |
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