Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/21646
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Natu, Mădălina V. | - |
dc.contributor.author | Gaspar, Manuel N. | - |
dc.contributor.author | Ribeiro, Carlos A. Fontes | - |
dc.contributor.author | Correia, Ilídio J. | - |
dc.contributor.author | Silva, Daniela | - |
dc.contributor.author | Sousa, Hermínio C. de | - |
dc.contributor.author | Gil, M. H. | - |
dc.date.accessioned | 2013-02-14T14:40:10Z | - |
dc.date.available | 2013-02-14T14:40:10Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | NATU, Mădălina V. [et al.] - A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug. "Biomedical Materials". ISSN 1748-60416. 6:2 (2011) 9 p. | por |
dc.identifier.issn | 1748-6041 | - |
dc.identifier.uri | https://hdl.handle.net/10316/21646 | - |
dc.description.abstract | Implantable dorzolamide-loaded discs were prepared by blending poly(ε-caprolactone), PCL, with poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), Lu. By blending, crystallinity, water uptake and mass loss were modified relative to the pure polymers. Burst was diminished by coating the discs with a PCL shell. All samples presented burst release except PCL-coated samples that showed controlled release during 18 days. For PCL-coated samples, barrier control of diffusion coupled with partition control from the core slowed down the release, while for 50/50 Lu/PCL-coated samples, the enhancement in the porosity of the core diminished partition control of drug release. Nonlinear regression analysis suggested that a degradation model fully describes the release curve considering a triphasic release mechanism: the instantaneous diffusion (burst), diffusion and polymer degradation stages. The MTT test indicated that the materials are not cytotoxic for corneal endothelial cells. A good in vitro–in vivo correlation was obtained, with similar amounts of drug released in vitro and in vivo. The discs decreased intraocular pressure (IOP) in normotensive rabbit eyes by 13.0% during 10 days for PCL-coated and by 13.0% during 4 days for 50/50 Lu/PCL-coated samples. The percentages of IOP decrease are similar to those obtained by dorzolamide eyedrop instillation (11.0%). | por |
dc.language.iso | eng | por |
dc.publisher | IOP Publishing | por |
dc.rights | closedAccess | por |
dc.title | A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug | por |
dc.type | article | por |
degois.publication.firstPage | 9 p. | por |
degois.publication.issue | 2 | por |
degois.publication.title | Biomedical Materials | por |
dc.date.embargoEndDate | 10000-01-01 | - |
dc.relation.publisherversion | http://iopscience.iop.org/1748-605X/6/2/025003 | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1088/1748-6041/6/2/025003 | - |
degois.publication.volume | 6 | por |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | reserved | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIEPQPF – Chemical Process Engineering and Forest Products Research Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-9707-4895 | - |
crisitem.author.orcid | 0000-0003-1613-9675 | - |
crisitem.author.orcid | 0000-0002-2629-7805 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais FCTUC Eng.Química - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | Login |
---|---|---|---|---|
2011 BM Natu.pdf | 650.21 kB | Adobe PDF | Request a copy |
SCOPUSTM
Citations
21
checked on Apr 15, 2024
WEB OF SCIENCETM
Citations
5
19
checked on Apr 2, 2024
Page view(s) 50
518
checked on Apr 16, 2024
Download(s)
97
checked on Apr 16, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.