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Title: | Exposure to Obesogenic Environments during Perinatal Development Modulates Offspring Energy Balance Pathways in Adipose Tissue and Liver of Rodent Models | Authors: | Sousa, Diana Sá-Rocha, Mariana Amaro, Andreia Ferreira-Junior, Marcos Divino Cavalcante, Keilah Valéria Naves Monteiro-Alfredo, Tamaeh Barra, Cátia Rosendo-Silva, Daniela Saavedra, Lucas Paulo Jacinto Magalhães, José Caseiro, Armando Freitas Mathias, Paulo Cezar de Pereira, Susana P. Oliveira, Paulo J. Gomes, Rodrigo Mello Matafome, Paulo |
Keywords: | metabolic diseases; energy balance; metabolic programming; sugars and AGEs; obesity/adipose tissue | Issue Date: | 4-Mar-2023 | Publisher: | MDPI | Project: | This work was supported by Portugal Foundation for Science and Technology (strategic projects UIDB/04539/2020, UIDP/04539/2020, and LA/P/0058/2020: CIBB), PTDC/DTPDES/ 1082/2014 (POCI-01-0145-FEDER-016657), CENTRO-01-0246-FEDER-000010 (Multidisciplinary Institute of Ageing in Coimbra), and FCT-Post-doctoral Fellowship (SPP, SFRH/BPD/116061/2016). | Serial title, monograph or event: | Nutrients | Volume: | 15 | Issue: | 5 | Abstract: | Obesogenic environments such as Westernized diets, overnutrition, and exposure to glycation during gestation and lactation can alter peripheral neuroendocrine factors in offspring, predisposing for metabolic diseases in adulthood. Thus, we hypothesized that exposure to obesogenic environments during the perinatal period reprograms offspring energy balance mechanisms. Four rat obesogenic models were studied: maternal diet-induced obesity (DIO); early-life obesity induced by postnatal overfeeding; maternal glycation; and postnatal overfeeding combined with maternal glycation. Metabolic parameters, energy expenditure, and storage pathways in visceral adipose tissue (VAT) and the liver were analyzed. Maternal DIO increased VAT lipogenic [NPY receptor-1 (NPY1R), NPY receptor-2 (NPY2R), and ghrelin receptor], but also lipolytic/catabolic mechanisms [dopamine-1 receptor (D1R) and p-AMP-activated protein kinase (AMPK)] in male offspring, while reducing NPY1R in females. Postnatally overfed male animals only exhibited higher NPY2R levels in VAT, while females also presented NPY1R and NPY2R downregulation. Maternal glycation reduces VAT expandability by decreasing NPY2R in overfed animals. Regarding the liver, D1R was decreased in all obesogenic models, while overfeeding induced fat accumulation in both sexes and glycation the inflammatory infiltration. The VAT response to maternal DIO and overfeeding showed a sexual dysmorphism, and exposure to glycotoxins led to a thin-outside-fat-inside phenotype in overfeeding conditions and impaired energy balance, increasing the metabolic risk in adulthood. | URI: | https://hdl.handle.net/10316/113898 | ISSN: | 2072-6643 | DOI: | 10.3390/nu15051281 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FCTUC Química - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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Exposure-to-Obesogenic-Environments-during-Perinatal-Development-Modulates-Offspring-Energy-Balance-Pathways-in-Adipose-Tissue-and-Liver-of-Rodent-ModelsNutrients.pdf | 9.09 MB | Adobe PDF | View/Open |
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