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Title: Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer
Authors: Coelho, Margarida 
Capela, João
Anjo, Sandra I. 
Pacheco, João
Fernandes, Margarida Sá
Amendoeira, Isabel
Jones, John G. 
Raposo, Luís
Manadas, Bruno 
Keywords: proteomics; screening; thyroid cancer; annexins; Sp1
Issue Date: 26-Sep-2023
Publisher: MDPI
Project: This work was supported by the Ph.D. fellowship PD/BD/135178/2017, funded by Fundação para a Ciência e Tecnologia (FCT) and integrated into the doctoral program in Nuclear Magnetic Resonance (NMR) applied to Chemistry,Materials and Biosciences (PD/00065/2013). This work was also financed by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme and through the COMPETE 2020-Operational Programme for Competitiveness and Internationalisation (OPCI) as well as by Portuguese national funds via FCT–Fundação para a Ciência e a Tecnologia, under the UIDB/04539/2020, UIDP/04539/2020, LA/P/0058/2020, POCI-01- 0145-FEDER-029311, POCI-01-0145-FEDER-030943, PTDC/MED-NEU/27946/2017, and FCT-FEDER- 02/SAICT/2017/028147 projects. Mass spectrometers are part of the National Mass Spectrometry Network (RNEM) under the contract POCI-01-0145-FEDER-402-022125 (ref.: ROTEIRO/0028/2013). 
Serial title, monograph or event: International Journal of Molecular Sciences
Volume: 24
Issue: 19
Abstract: Differentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therapeutic targets. Proteomics analysis of benign and malignant human thyroid tissue largely revealed changes indicating modifications in RNA regulation, a common cancer characteristic. In addition, changes in the immune system and cell membrane/endocytic processes were also suggested to be involved. Annexin A1 was considered a potential malignancy biomarker and, similarly to other annexins, it was found to increase in the malignant group. Furthermore, a bioinformatics approach points to the transcription factor Sp1 as being potentially involved in most of the alterations seen in the malignant thyroid nodules.
ISSN: 1422-0067
DOI: 10.3390/ijms241914542
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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