Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/111881
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dc.contributor.authorCoelho, Margarida-
dc.contributor.authorCapela, João-
dc.contributor.authorAnjo, Sandra I.-
dc.contributor.authorPacheco, João-
dc.contributor.authorFernandes, Margarida Sá-
dc.contributor.authorAmendoeira, Isabel-
dc.contributor.authorJones, John G.-
dc.contributor.authorRaposo, Luís-
dc.contributor.authorManadas, Bruno-
dc.date.accessioned2024-01-16T08:48:03Z-
dc.date.available2024-01-16T08:48:03Z-
dc.date.issued2023-09-26-
dc.identifier.issn1422-0067pt
dc.identifier.urihttps://hdl.handle.net/10316/111881-
dc.description.abstractDifferentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therapeutic targets. Proteomics analysis of benign and malignant human thyroid tissue largely revealed changes indicating modifications in RNA regulation, a common cancer characteristic. In addition, changes in the immune system and cell membrane/endocytic processes were also suggested to be involved. Annexin A1 was considered a potential malignancy biomarker and, similarly to other annexins, it was found to increase in the malignant group. Furthermore, a bioinformatics approach points to the transcription factor Sp1 as being potentially involved in most of the alterations seen in the malignant thyroid nodules.pt
dc.language.isoengpt
dc.publisherMDPIpt
dc.relationThis work was supported by the Ph.D. fellowship PD/BD/135178/2017, funded by Fundação para a Ciência e Tecnologia (FCT) and integrated into the doctoral program in Nuclear Magnetic Resonance (NMR) applied to Chemistry,Materials and Biosciences (PD/00065/2013). This work was also financed by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme and through the COMPETE 2020-Operational Programme for Competitiveness and Internationalisation (OPCI) as well as by Portuguese national funds via FCT–Fundação para a Ciência e a Tecnologia, under the UIDB/04539/2020, UIDP/04539/2020, LA/P/0058/2020, POCI-01- 0145-FEDER-029311, POCI-01-0145-FEDER-030943, PTDC/MED-NEU/27946/2017, and FCT-FEDER- 02/SAICT/2017/028147 projects. Mass spectrometers are part of the National Mass Spectrometry Network (RNEM) under the contract POCI-01-0145-FEDER-402-022125 (ref.: ROTEIRO/0028/2013).pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectproteomicspt
dc.subjectscreeningpt
dc.subjectthyroid cancerpt
dc.subjectannexinspt
dc.subjectSp1pt
dc.subject.meshHumanspt
dc.subject.meshAnnexinspt
dc.subject.meshRNA, Messengerpt
dc.subject.meshProteomicspt
dc.subject.meshThyroid Nodulept
dc.subject.meshThyroid Neoplasmspt
dc.titleProteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancerpt
dc.typearticle-
degois.publication.firstPage14542pt
degois.publication.issue19pt
degois.publication.titleInternational Journal of Molecular Sciencespt
dc.peerreviewedyespt
dc.identifier.doi10.3390/ijms241914542pt
degois.publication.volume24pt
dc.date.embargo2023-09-26*
uc.date.periodoEmbargo0pt
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
crisitem.author.orcid0000-0002-0392-1118-
crisitem.author.orcid0000-0002-3745-3885-
crisitem.author.orcid0000-0002-2087-4042-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
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