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https://hdl.handle.net/10316/111881
Título: | Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer | Autor: | Coelho, Margarida Capela, João Anjo, Sandra I. Pacheco, João Fernandes, Margarida Sá Amendoeira, Isabel Jones, John G. Raposo, Luís Manadas, Bruno |
Palavras-chave: | proteomics; screening; thyroid cancer; annexins; Sp1 | Data: | 26-Set-2023 | Editora: | MDPI | Projeto: | PD/BD/135178/2017 PD/00065/2013 UIDB/04539/2020 info:eu-repo/grantAgreement/UIDP/04539/2020 LA/P/0058/2020 POCI-01- 0145-FEDER-029311 POCI-01-0145-FEDER-030943 PTDC/MED-NEU/27946/2017 FEDER- 02/SAICT/2017/028147 POCI-01-0145-FEDER-402-022125 |
Título da revista, periódico, livro ou evento: | International Journal of Molecular Sciences | Volume: | 24 | Número: | 19 | Resumo: | Differentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therapeutic targets. Proteomics analysis of benign and malignant human thyroid tissue largely revealed changes indicating modifications in RNA regulation, a common cancer characteristic. In addition, changes in the immune system and cell membrane/endocytic processes were also suggested to be involved. Annexin A1 was considered a potential malignancy biomarker and, similarly to other annexins, it was found to increase in the malignant group. Furthermore, a bioinformatics approach points to the transcription factor Sp1 as being potentially involved in most of the alterations seen in the malignant thyroid nodules. | URI: | https://hdl.handle.net/10316/111881 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms241914542 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Química - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Proteomics-Reveals-mRNA-Regulation-and-the-Action-of-Annexins-in-Thyroid-CancerInternational-Journal-of-Molecular-Sciences.pdf | 3.23 MB | Adobe PDF | Ver/Abrir |
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