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Título: | Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism | Autor: | Almeida, Nuno Carrara, Guia Palmeira, Carlos M. Fernandes, Ana S. Parsons, Maddy Smith, Geoffrey L. Saraiva, Nuno |
Palavras-chave: | Calcium; Cell invasion; Golgi apparatus; Hydrogen peroxide; Metabolism; TMBIM | Data: | Jan-2020 | Editora: | Elsevier | Projeto: | UID/DTP/04567/2019 Isaac Newton grant UID/DTP/04567/2016 STSM grants from EU-ROS (BM1203) and EuroCellNet (CA15214) COST actions GLS is a Wellcome Trust Principal Research Fellow [090315/B/09] |
Título da revista, periódico, livro ou evento: | Redox Biology | Volume: | 28 | Resumo: | The mechanisms by which the Golgi apparatus (GA) impacts on cell invasion are poorly understood. The human Golgi Anti-Apoptotic Protein (hGAAP, also known as TMBIM4) is a highly conserved Golgi cation channel that modulates intracellular Ca2+ fluxes. Human GAAP is expressed in all human tissues, is essential for cell viability and provides resistance against a range of apoptotic stresses. Furthermore, hGAAP enhances adhesion and cell migration by increasing the turnover of focal adhesions due to activation of store-operated Ca2+ entry. Here, we describe a GA-derived mechanism that controls cell invasion. The overexpression of hGAAP stimulates 3-dimensional proteolytic cell invasion by a mechanism that is dependent on the accumulation of intracellular hydrogen peroxide, which might be produced by the hGAAP-dependent stimulation of mitochondrial respiration. These findings provide new insight into the complex mechanisms by which Ca2+ and reactive oxygen species signaling contribute to cell invasion and to the role of the GA in these processes. | URI: | https://hdl.handle.net/10316/106653 | ISSN: | 22132317 | DOI: | 10.1016/j.redox.2019.101361 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Stimulation of cell invasion by the Golgi Ion Channel GAAPTMBIM4 via an H2O2-Dependent Mechanism.pdf | 1.88 MB | Adobe PDF | Ver/Abrir |
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