Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/106653
DC Field | Value | Language |
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dc.contributor.author | Almeida, Nuno | - |
dc.contributor.author | Carrara, Guia | - |
dc.contributor.author | Palmeira, Carlos M. | - |
dc.contributor.author | Fernandes, Ana S. | - |
dc.contributor.author | Parsons, Maddy | - |
dc.contributor.author | Smith, Geoffrey L. | - |
dc.contributor.author | Saraiva, Nuno | - |
dc.date.accessioned | 2023-04-14T08:30:07Z | - |
dc.date.available | 2023-04-14T08:30:07Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 22132317 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/106653 | - |
dc.description.abstract | The mechanisms by which the Golgi apparatus (GA) impacts on cell invasion are poorly understood. The human Golgi Anti-Apoptotic Protein (hGAAP, also known as TMBIM4) is a highly conserved Golgi cation channel that modulates intracellular Ca2+ fluxes. Human GAAP is expressed in all human tissues, is essential for cell viability and provides resistance against a range of apoptotic stresses. Furthermore, hGAAP enhances adhesion and cell migration by increasing the turnover of focal adhesions due to activation of store-operated Ca2+ entry. Here, we describe a GA-derived mechanism that controls cell invasion. The overexpression of hGAAP stimulates 3-dimensional proteolytic cell invasion by a mechanism that is dependent on the accumulation of intracellular hydrogen peroxide, which might be produced by the hGAAP-dependent stimulation of mitochondrial respiration. These findings provide new insight into the complex mechanisms by which Ca2+ and reactive oxygen species signaling contribute to cell invasion and to the role of the GA in these processes. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier | pt |
dc.relation | UID/DTP/04567/2019 | pt |
dc.relation | Isaac Newton grant | pt |
dc.relation | UID/DTP/04567/2016 | pt |
dc.relation | STSM grants from EU-ROS (BM1203) and EuroCellNet (CA15214) COST actions | pt |
dc.relation | GLS is a Wellcome Trust Principal Research Fellow [090315/B/09] | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Calcium | pt |
dc.subject | Cell invasion | pt |
dc.subject | Golgi apparatus | pt |
dc.subject | Hydrogen peroxide | pt |
dc.subject | Metabolism | pt |
dc.subject | TMBIM | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Calcium Signaling | pt |
dc.subject.mesh | Cell Adhesion | pt |
dc.subject.mesh | Cell Line, Tumor | pt |
dc.subject.mesh | Cell Movement | pt |
dc.subject.mesh | Cell Survival | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Hydrogen Peroxide | pt |
dc.subject.mesh | MCF-7 Cells | pt |
dc.subject.mesh | Membrane Proteins | pt |
dc.subject.mesh | Mice | pt |
dc.subject.mesh | Mitochondria | pt |
dc.subject.mesh | Neoplasm Invasiveness | pt |
dc.subject.mesh | Neoplasm Transplantation | pt |
dc.subject.mesh | Neoplasms | pt |
dc.subject.mesh | Reactive Oxygen Species | pt |
dc.subject.mesh | Up-Regulation | pt |
dc.title | Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism | pt |
dc.type | article | - |
degois.publication.firstPage | 101361 | pt |
degois.publication.title | Redox Biology | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.redox.2019.101361 | pt |
degois.publication.volume | 28 | pt |
dc.date.embargo | 2020-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | LAETA - Associated Laboratory for Energy, Transports and Aeronautics | - |
crisitem.author.researchunit | ADAI - Association for the Development of Industrial Aerodynamics | - |
crisitem.author.orcid | 0000-0002-2639-7697 | - |
crisitem.author.orcid | 0000-0002-7805-002X | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Stimulation of cell invasion by the Golgi Ion Channel GAAPTMBIM4 via an H2O2-Dependent Mechanism.pdf | 1.88 MB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License