Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/10535
Title: | Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation, and SAR of Epoxysterols | Authors: | Carvalho, João F. S. Silva, M. Manuel Cruz Moreira, João N. Simões, Sérgio Melo, M. Luísa Sá e |
Issue Date: | 9-Jul-2009 | Publisher: | American Chemical Society | Citation: | Journal of Medicinal Chemistry. 52:13 (2009) 4007-4019 | Abstract: | A library of diastereomerically pure epoxysterols, prepared by combining chemical and enzymatic methodologies, was evaluated for cytotoxicity toward human cancer and noncancer cell lines. Unsaturated steroids were oxidized by magnesium bis(monoperoxyphthalate) hexahydrate in acetonitrile, and the resulting epimeric epoxides were enzymatically separated using Novozym 435 or lipase AY. Some of the synthesized epoxysterols have potent cytotoxicity and higher activity on cancer cell lines HT29 and LAMA-84. | URI: | https://hdl.handle.net/10316/10535 | ISSN: | 0022-2623 | DOI: | 10.1021/jm9003973 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation.pdf | 1.03 MB | Adobe PDF | View/Open |
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