Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/10535
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Carvalho, João F. S. | - |
dc.contributor.author | Silva, M. Manuel Cruz | - |
dc.contributor.author | Moreira, João N. | - |
dc.contributor.author | Simões, Sérgio | - |
dc.contributor.author | Melo, M. Luísa Sá e | - |
dc.date.accessioned | 2009-07-07T14:09:55Z | - |
dc.date.available | 2009-07-07T14:09:55Z | - |
dc.date.issued | 2009-07-09 | - |
dc.identifier.citation | Journal of Medicinal Chemistry. 52:13 (2009) 4007-4019 | en_US |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | https://hdl.handle.net/10316/10535 | - |
dc.description.abstract | A library of diastereomerically pure epoxysterols, prepared by combining chemical and enzymatic methodologies, was evaluated for cytotoxicity toward human cancer and noncancer cell lines. Unsaturated steroids were oxidized by magnesium bis(monoperoxyphthalate) hexahydrate in acetonitrile, and the resulting epimeric epoxides were enzymatically separated using Novozym 435 or lipase AY. Some of the synthesized epoxysterols have potent cytotoxicity and higher activity on cancer cell lines HT29 and LAMA-84. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | openAccess | eng |
dc.title | Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation, and SAR of Epoxysterols | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1021/jm9003973 | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-1938-4150 | - |
crisitem.author.orcid | 0000-0003-3449-0522 | - |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation.pdf | 1.03 MB | Adobe PDF | Ver/Abrir |
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