Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/10535
Title: Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation, and SAR of Epoxysterols
Authors: Carvalho, João F. S. 
Silva, M. Manuel Cruz 
Moreira, João N. 
Simões, Sérgio 
Melo, M. Luísa Sá e 
Issue Date: 9-Jul-2009
Publisher: American Chemical Society
Citation: Journal of Medicinal Chemistry. 52:13 (2009) 4007-4019
Abstract: A library of diastereomerically pure epoxysterols, prepared by combining chemical and enzymatic methodologies, was evaluated for cytotoxicity toward human cancer and noncancer cell lines. Unsaturated steroids were oxidized by magnesium bis(monoperoxyphthalate) hexahydrate in acetonitrile, and the resulting epimeric epoxides were enzymatically separated using Novozym 435 or lipase AY. Some of the synthesized epoxysterols have potent cytotoxicity and higher activity on cancer cell lines HT29 and LAMA-84.
URI: http://hdl.handle.net/10316/10535
ISSN: 0022-2623
DOI: 10.1021/jm9003973
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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