Cunha-Oliveira, Teresa
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Credit Name
Cunha-Oliveira, Teresa
Name
Cunha-Oliveira, Teresa
Variants
Oliveira, M.T.
Cunha-Oliveira, T.
Oliveira, T.C.
Cunha-Oliveira, T.
Oliveira, T.C.
Email
teresa.oliveira@uc-biotech.pt
Other emails
https://orcid.org/0000-0002-7382-0339
Scopus Author ID
Researcher ID
Status
UC Researcher
Biography
Teresa Cunha-Oliveira got her PhD in Biology (Cell Biology) in 2007 from the University of Coimbra (Portugal), having contributed to introduce the role of mitochondria in the field of drug addiction, particularly concerning cocaine, heroin and amphetamine. In her first post-doctoral period (2007-2010) in the Center for Neuroscience and Cell Biology (CNC, Coimbra), she collaborated with a Medicinal Chemistry group at the University of Porto to uncover the cellular effects of a newly found chemical interaction between heroin and cocaine (speedball) that could have a great impact in the understanding of poly-drug abuse consequences. In her second post-doctoral period (2010-2012), she was focused on the role of mitochondria in neurodegenerative diseases, including Huntington’s disease (HD) and Parkinson’s disease. She became interested in the epigenetic mechanisms associated with long-term mitochondrial dysfunction and contributed to characterize the bioenergetic dysfunction in cybrids from HD patients, evidencing the involvement of pyruvate dehydrogenase (PDH) and the promising role of epigenetic modulators in reversing PDH and mitochondrial dysfunctions in HD models. From 2013 until now, she is part of the MitoXT group at the CNC, more interested in the role of mitochondria in drug toxicology and experimental therapeutics, especially doxorubicin (DOX), an anticancer agent with long-term cardiotoxic side-effects involving mitochondria. She contributed to describe DOX-induced mitochondrial dysfunction, transcriptional deregulation and epigenetic signalling using in vitro and in vivo models. Her current interests include the development and validation of innovative screening assays to assess mitochondrial health with applications in toxicology, diagnostics and development of innovative therapeutic strategies for personalized medicine.
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Publications
(All)
Type
Fulltext
Results 1-5 of 5 (Search time: 0.011 seconds).
| Issue Date | Title | Author(s) | Type | Access | |
|---|---|---|---|---|---|
| 1 | 2013 | Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria | Cunha-Oliveira, Teresa ; Silva, Lisbeth ; Silva, Ana Maria ; Moreno, António J. ; Oliveira, Catarina R. ; Santos, Maria S. | article | openAccess |
| 2 | 2013 | Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition | Bernardo, Telma C. ; Cunha-Oliveira, Teresa ; Serafim, Teresa L. ; Holy, Jon ; Krasutsky, Dmytro ; Kolomitsyna, Oksana ; Krasutsky, Pavel ; Moreno, A. J. M. ; Oliveira, Paulo J. | article | openAccess |
| 3 | 2013 | Medical Toxicology of Drugs of Abuse | Cunha-Oliveira, Teresa ; Rego, Ana Cristina ; Carvalho, Félix ; Oliveira, Catarina R. | bookPart | openAccess |
| 4 | 1-May-2013 | Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria | Cunha-Oliveira, Teresa ; Silva, Lisbeth ; Silva, Ana Maria ; Moreno, António J. ; Oliveira, Catarina R. ; Santos, Maria S. | article | openAccess |
| 5 | Sep-2013 | Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse | Perfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina | article | openAccess |