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|Title:||Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis||Authors:||Salazar, Ivan L.
Lourenço, Ana S. T.
Teixeira, Anabela Claro
Mendes, Vera M.
Novo, Ana Margarida
Macário, Maria do Carmo
Saraiva, Maria João
Pais, Alberto A. C. C.
Duarte, Carlos B.
|Keywords:||Biomarkers; Cerebrospinal fluid (CSF); Multiple sclerosis; Transthyretin (TTR)||Issue Date:||8-Feb-2022||Publisher:||BMC||Project:||BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
|Serial title, monograph or event:||Journal of Neuroinflammation||Volume:||19||Issue:||1||Abstract:||Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and concomitant axonal loss. The lack of a single specific test, and the similarity to other inflammatory diseases of the central nervous system, makes it difficult to have a clear diagnosis of multiple sclerosis. Therefore, laboratory tests that allows a clear and definite diagnosis, as well as to predict the different clinical courses of the disease are of utmost importance. Herein, we compared the cerebrospinal fluid (CSF) proteome of patients with multiple sclerosis (in the relapse-remitting phase of the disease) and other diseases of the CNS (inflammatory and non-inflammatory) aiming at identifying reliable biomarkers of multiple sclerosis.||URI:||http://hdl.handle.net/10316/99647||ISSN:||1742-2094||DOI:||10.1186/s12974-022-02404-2||Rights:||openAccess|
|Appears in Collections:||FCTUC Química - Artigos em Revistas Internacionais|
I&D CNC - Artigos em Revistas Internacionais
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