Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/96599
Title: Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria
Authors: Esteves, A. Raquel 
Munoz-Pinto, Mário F.
Nunes-Costa, Daniela
Candeias, Emanuel 
Silva, Diana F. 
Magalhães, João D.
Pereira-Santos, A. Raquel 
Ferreira, I. Luisa
Alarico, Susana 
Tiago, Igor 
Empadinhas, Nuno 
Cardoso, Sandra Morais 
Keywords: Gut inflammation; Intestinal bacteria; Intestinal barrier function; Neurobiology
Issue Date: 26-Nov-2021
Publisher: BMJ
Project: CENTRO-01-0145-FEDER-000012 (HealthyAging 2020) 
PTDC/MED-NEU/3644/2020 
PINFRA/22184/2016 
POCI-01-0145-FEDER-022184 
UIDB/04539/2020 
PD/BD/146409/2019 
SFRH/BD/117777/2016 
PD/BD/06543/2020 
Serial title, monograph or event: Gut
Abstract: Idiopathic Parkinson's disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impact the brain. In this work, we sought to demonstrate that the effects of the microbial toxin β-N-methylamino-L-alanine (BMAA) in the gut may trigger some PD cases, which is especially worrying as this toxin is present in certain foods but not routinely monitored by public health authorities.
URI: http://hdl.handle.net/10316/96599
ISSN: 0017-5749
1468-3288
DOI: 10.1136/gutjnl-2021-326023
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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