Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/96599
DC Field | Value | Language |
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dc.contributor.author | Esteves, A. Raquel | - |
dc.contributor.author | Munoz-Pinto, Mário F. | - |
dc.contributor.author | Nunes-Costa, Daniela | - |
dc.contributor.author | Candeias, Emanuel | - |
dc.contributor.author | Silva, Diana F. | - |
dc.contributor.author | Magalhães, João D. | - |
dc.contributor.author | Pereira-Santos, A. Raquel | - |
dc.contributor.author | Ferreira, I. Luisa | - |
dc.contributor.author | Alarico, Susana | - |
dc.contributor.author | Tiago, Igor | - |
dc.contributor.author | Empadinhas, Nuno | - |
dc.contributor.author | Cardoso, Sandra Morais | - |
dc.date.accessioned | 2021-12-01T15:35:33Z | - |
dc.date.available | 2021-12-01T15:35:33Z | - |
dc.date.issued | 2021-11-26 | - |
dc.identifier.issn | 0017-5749 | pt |
dc.identifier.issn | 1468-3288 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/96599 | - |
dc.description.abstract | Idiopathic Parkinson's disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impact the brain. In this work, we sought to demonstrate that the effects of the microbial toxin β-N-methylamino-L-alanine (BMAA) in the gut may trigger some PD cases, which is especially worrying as this toxin is present in certain foods but not routinely monitored by public health authorities. | pt |
dc.description.sponsorship | This work was funded by Santa Casa da Misericórdia de Lisboa, Portugal, through Mantero Belard Neurosciences Prize 2016 (MB-40-2016); by FMUCPEPITA (2018); by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-01-0145-FEDER-000012 (HealthyAging 2020) and through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalization and by Portuguese national funds via FCT—Fundação para a Ciência e a Tecnologia under projects PTDC/MED-NEU/3644/2020, PINFRA/22184/2016/POCI-01-0145-FEDER-022184 and UIDB/04539/2020. EC was supported by fellowship MB-40-2016. IT was supported by IF/01061/2014 Investigator contract. JDM is supported by PhD fellowship PD/BD/146409/2019, DN-C is supported by PhD fellowship SFRH/BD | pt |
dc.language.iso | eng | pt |
dc.publisher | BMJ | pt |
dc.relation | CENTRO-01-0145-FEDER-000012 (HealthyAging 2020) | pt |
dc.relation | PTDC/MED-NEU/3644/2020 | pt |
dc.relation | PINFRA/22184/2016 | pt |
dc.relation | POCI-01-0145-FEDER-022184 | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | PD/BD/146409/2019 | pt |
dc.relation | SFRH/BD/117777/2016 | pt |
dc.relation | PD/BD/06543/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt |
dc.subject | Gut inflammation | pt |
dc.subject | Intestinal bacteria | pt |
dc.subject | Intestinal barrier function | pt |
dc.subject | Neurobiology | pt |
dc.title | Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria | pt |
dc.type | article | - |
degois.publication.firstPage | gutjnl-2021-326023 | pt |
degois.publication.title | Gut | pt |
dc.relation.publisherversion | https://gut.bmj.com/content/early/2021/11/29/gutjnl-2021-326023.info | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1136/gutjnl-2021-326023 | pt |
dc.date.embargo | 2021-11-26 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CFE - Centre for Functional Ecology - Science for People & the Planet | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-8403-2015 | - |
crisitem.author.orcid | 0000-0002-0612-2645 | - |
crisitem.author.orcid | 0000-0002-1615-6099 | - |
crisitem.author.orcid | 0000-0001-8938-7560 | - |
crisitem.author.orcid | 0000-0002-2199-0555 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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gutjnl-2021-326023.full.pdf | 12.57 MB | Adobe PDF | View/Open |
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