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Título: | Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats | Autor: | Monteiro-Alfredo, Tamaeh Oliveira, Sara Amaro, Andreia Rosendo-Silva, Daniela Antunes, Katia Pires, Ana Salomé dos Santos Teixo, Ricardo Jorge Marques Abrantes, Ana Margarida Coelho Botelho, Maria Filomena Castelo-Branco, Miguel Seiça, Raquel Silva, Sónia de Picoli Souza, Kely Matafome, Paulo Nuno Centeio |
Palavras-chave: | Bocaiúva; Dabetes; Macaúba; Polyphenols; Vascular function | Data: | 20-Ago-2021 | Editora: | MDPI | Projeto: | PEst UID/NEU/04539/2013 ItemCrisRefDisplayStrategy.project.deleted.icon PEst UIDB/04539/2020 UID/NEU/04539/2019 UIDP/04539/2020 |
Título da revista, periódico, livro ou evento: | Nutrients | Volume: | 13 | Número: | 8 | Resumo: | Oxidative stress is involved in the metabolic dysregulation of type 2 diabetes (DM2). Acrocomia aculeata (Aa) fruit pulp has been described for the treatment of several diseases, and recently we have proved that its leaves have phenolic compounds with a marked antioxidant effect. We aimed to assess whether they can improve metabolic, redox and vascular functions in DM2. Control Wistar (W-Ctrl) and non-obese type 2 diabetic Goto-Kakizaki (GK-Ctrl) rats were treated for 30 days with 200 mg.kg-1 aqueous extract of Aa (EA-Aa) (Wistar, W-EA-Aa/GK, GK-EA-Aa). EA-Aa was able to reduce fasting glycaemia and triglycerides of GK-EA-Aa by improving proteins related to glucose and lipid metabolism, such as GLUT-4, PPARγ, AMPK, and IR, when compared to GK-Ctrl. It also improved viability of 3T3-L1 pre-adipocytes exposed by H2O2. EA-Aa also increased the levels of catalase in the aorta and kidney, reduced oxidative stress and increased relaxation of the aorta in GK-treated rats in relation to GK-Ctrl, in addition to the protective effect against oxidative stress in HMVec-D cells. We proved the direct antioxidant potential of the chemical compounds of EA-Aa, the increase in antioxidant defences in a tissue-specific manner and hypoglycaemic properties, improving vascular function in type 2 diabetes. EA-Aa and its constituents may have a therapeutic potential for the treatment of DM2 complications. | URI: | https://hdl.handle.net/10316/95718 | ISSN: | 2072-6643 | DOI: | 10.3390/nu13082856 | Direitos: | openAccess |
Aparece nas coleções: | I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D CFE - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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nutrients-13-02856-v2.pdf | 4.79 MB | Adobe PDF | Ver/Abrir |
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