Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/95718
DC Field | Value | Language |
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dc.contributor.author | Monteiro-Alfredo, Tamaeh | - |
dc.contributor.author | Oliveira, Sara | - |
dc.contributor.author | Amaro, Andreia | - |
dc.contributor.author | Rosendo-Silva, Daniela | - |
dc.contributor.author | Antunes, Katia | - |
dc.contributor.author | Pires, Ana Salomé dos Santos | - |
dc.contributor.author | Teixo, Ricardo Jorge Marques | - |
dc.contributor.author | Abrantes, Ana Margarida Coelho | - |
dc.contributor.author | Botelho, Maria Filomena | - |
dc.contributor.author | Castelo-Branco, Miguel | - |
dc.contributor.author | Seiça, Raquel | - |
dc.contributor.author | Silva, Sónia | - |
dc.contributor.author | de Picoli Souza, Kely | - |
dc.contributor.author | Matafome, Paulo Nuno Centeio | - |
dc.date.accessioned | 2021-09-10T16:10:16Z | - |
dc.date.available | 2021-09-10T16:10:16Z | - |
dc.date.issued | 2021-08-20 | - |
dc.identifier.issn | 2072-6643 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/95718 | - |
dc.description.abstract | Oxidative stress is involved in the metabolic dysregulation of type 2 diabetes (DM2). Acrocomia aculeata (Aa) fruit pulp has been described for the treatment of several diseases, and recently we have proved that its leaves have phenolic compounds with a marked antioxidant effect. We aimed to assess whether they can improve metabolic, redox and vascular functions in DM2. Control Wistar (W-Ctrl) and non-obese type 2 diabetic Goto-Kakizaki (GK-Ctrl) rats were treated for 30 days with 200 mg.kg-1 aqueous extract of Aa (EA-Aa) (Wistar, W-EA-Aa/GK, GK-EA-Aa). EA-Aa was able to reduce fasting glycaemia and triglycerides of GK-EA-Aa by improving proteins related to glucose and lipid metabolism, such as GLUT-4, PPARγ, AMPK, and IR, when compared to GK-Ctrl. It also improved viability of 3T3-L1 pre-adipocytes exposed by H2O2. EA-Aa also increased the levels of catalase in the aorta and kidney, reduced oxidative stress and increased relaxation of the aorta in GK-treated rats in relation to GK-Ctrl, in addition to the protective effect against oxidative stress in HMVec-D cells. We proved the direct antioxidant potential of the chemical compounds of EA-Aa, the increase in antioxidant defences in a tissue-specific manner and hypoglycaemic properties, improving vascular function in type 2 diabetes. EA-Aa and its constituents may have a therapeutic potential for the treatment of DM2 complications. | pt |
dc.description.sponsorship | This work was supported by grants from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | PEst UID/NEU/04539/2013 | pt |
dc.relation | PEst UIDB/04539/2020 | pt |
dc.relation | UID/NEU/04539/2019 | pt |
dc.relation | UIDP/04539/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Bocaiúva | pt |
dc.subject | Dabetes | pt |
dc.subject | Macaúba | pt |
dc.subject | Polyphenols | pt |
dc.subject | Vascular function | pt |
dc.title | Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats | pt |
dc.type | article | - |
degois.publication.firstPage | 2856 | pt |
degois.publication.issue | 8 | pt |
degois.publication.title | Nutrients | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/nu13082856 | pt |
degois.publication.volume | 13 | pt |
dc.date.embargo | 2021-08-20 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0001-5514-0797 | - |
crisitem.author.orcid | 0000-0001-7994-4650 | - |
crisitem.author.orcid | 0000-0003-4185-7871 | - |
crisitem.author.orcid | 0000-0001-7202-1650 | - |
crisitem.author.orcid | 0000-0003-4364-6373 | - |
crisitem.author.orcid | 0000-0002-8378-0895 | - |
crisitem.author.orcid | 0000-0002-3422-290X | - |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D CFE - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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nutrients-13-02856-v2.pdf | 4.79 MB | Adobe PDF | View/Open |
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