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Title: Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats
Authors: Monteiro-Alfredo, Tamaeh
Oliveira, Sara
Amaro, Andreia
Rosendo-Silva, Daniela
Antunes, Katia
Pires, Ana Salomé dos Santos 
Teixo, Ricardo Jorge Marques 
Abrantes, Ana Margarida Coelho 
Botelho, Maria Filomena 
Castelo-Branco, Miguel 
Seiça, Raquel 
Silva, Sónia
de Picoli Souza, Kely
Matafome, Paulo Nuno Centeio 
Keywords: Bocaiúva; Dabetes; Macaúba; Polyphenols; Vascular function
Issue Date: 20-Aug-2021
Publisher: MDPI
Project: PEst UID/NEU/04539/2013 
PEst UIDB/04539/2020 
Serial title, monograph or event: Nutrients
Volume: 13
Issue: 8
Abstract: Oxidative stress is involved in the metabolic dysregulation of type 2 diabetes (DM2). Acrocomia aculeata (Aa) fruit pulp has been described for the treatment of several diseases, and recently we have proved that its leaves have phenolic compounds with a marked antioxidant effect. We aimed to assess whether they can improve metabolic, redox and vascular functions in DM2. Control Wistar (W-Ctrl) and non-obese type 2 diabetic Goto-Kakizaki (GK-Ctrl) rats were treated for 30 days with 200 aqueous extract of Aa (EA-Aa) (Wistar, W-EA-Aa/GK, GK-EA-Aa). EA-Aa was able to reduce fasting glycaemia and triglycerides of GK-EA-Aa by improving proteins related to glucose and lipid metabolism, such as GLUT-4, PPARγ, AMPK, and IR, when compared to GK-Ctrl. It also improved viability of 3T3-L1 pre-adipocytes exposed by H2O2. EA-Aa also increased the levels of catalase in the aorta and kidney, reduced oxidative stress and increased relaxation of the aorta in GK-treated rats in relation to GK-Ctrl, in addition to the protective effect against oxidative stress in HMVec-D cells. We proved the direct antioxidant potential of the chemical compounds of EA-Aa, the increase in antioxidant defences in a tissue-specific manner and hypoglycaemic properties, improving vascular function in type 2 diabetes. EA-Aa and its constituents may have a therapeutic potential for the treatment of DM2 complications.
ISSN: 2072-6643
DOI: 10.3390/nu13082856
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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