Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/95659
Título: | Chronic Intermittent Hypoxia Induces Early-Stage Metabolic Dysfunction Independently of Adipose Tissue Deregulation | Autor: | Martins, Fátima O. Sacramento, Joana F. Olea, Elena Melo, Bernardete F. Prieto-Lloret, Jesus Obeso, Ana Rocher, Asuncion Matafome, Paulo Monteiro, Emilia C. Conde, Silvia V. |
Palavras-chave: | Obstructive sleep apnea; Metabolic dysfunction; Insulin resistance; Adipose tissue; Hypoxia; Inflammation; Oxidative stress | Data: | 2021 | Título da revista, periódico, livro ou evento: | Antioxidants | Volume: | 10 | Número: | 8 | Resumo: | Several studies demonstrated a link between obstructive sleep apnea (OSA) and the development of insulin resistance. However, the main event triggering insulin resistance in OSA remains to be clarified. Herein, we investigated the effect of mild and severe chronic intermittent hypoxia (CIH) on whole-body metabolic deregulation and visceral adipose tissue dysfunction. Moreover, we studied the contribution of obesity to CIH-induced dysmetabolic states. Experiments were performed in male Wistar rats submitted to a control and high-fat (HF) diet. Two CIH protocols were tested: A mild CIH paradigm (5/6 hypoxic (5% O2) cycles/h, 10.5 h/day) during 35 days and a severe CIH paradigm (30 hypoxic (5% O2) cycles, 8 h/day) during 15 days. Fasting glycemia, insulinemia, insulin sensitivity, weight, and fat mass were assessed. Adipose tissue hypoxia, inflammation, angiogenesis, oxidative stress, and metabolism were investigated. Mild and severe CIH increased insulin levels and induced whole-body insulin resistance in control animals, effects not associated with weight gain. In control animals, CIH did not modify adipocytes perimeter as well as adipose tissue hypoxia, angiogenesis, inflammation or oxidative stress. In HF animals, severe CIH attenuated the increase in adipocytes perimeter, adipose tissue hypoxia, angiogenesis, and dysmetabolism. In conclusion, adipose tissue dysfunction is not the main trigger for initial dysmetabolism in CIH. CIH in an early stage might have a protective role against the deleterious effects of HF diet on adipose tissue metabolism. | URI: | https://hdl.handle.net/10316/95659 | ISSN: | 2076-3921 | DOI: | 10.3390/antiox10081233 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
antioxidants-10-01233-v3.pdf | 4.12 MB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
3
Visto em 17/nov/2022
Citações WEB OF SCIENCETM
4
Visto em 2/mai/2023
Visualizações de página
186
Visto em 24/abr/2024
Downloads
91
Visto em 24/abr/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons