Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/95659
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dc.contributor.authorMartins, Fátima O.-
dc.contributor.authorSacramento, Joana F.-
dc.contributor.authorOlea, Elena-
dc.contributor.authorMelo, Bernardete F.-
dc.contributor.authorPrieto-Lloret, Jesus-
dc.contributor.authorObeso, Ana-
dc.contributor.authorRocher, Asuncion-
dc.contributor.authorMatafome, Paulo-
dc.contributor.authorMonteiro, Emilia C.-
dc.contributor.authorConde, Silvia V.-
dc.date.accessioned2021-08-19T15:37:11Z-
dc.date.available2021-08-19T15:37:11Z-
dc.date.issued2021-
dc.identifier.issn2076-3921pt
dc.identifier.urihttp://hdl.handle.net/10316/95659-
dc.description.abstractSeveral studies demonstrated a link between obstructive sleep apnea (OSA) and the development of insulin resistance. However, the main event triggering insulin resistance in OSA remains to be clarified. Herein, we investigated the effect of mild and severe chronic intermittent hypoxia (CIH) on whole-body metabolic deregulation and visceral adipose tissue dysfunction. Moreover, we studied the contribution of obesity to CIH-induced dysmetabolic states. Experiments were performed in male Wistar rats submitted to a control and high-fat (HF) diet. Two CIH protocols were tested: A mild CIH paradigm (5/6 hypoxic (5% O2) cycles/h, 10.5 h/day) during 35 days and a severe CIH paradigm (30 hypoxic (5% O2) cycles, 8 h/day) during 15 days. Fasting glycemia, insulinemia, insulin sensitivity, weight, and fat mass were assessed. Adipose tissue hypoxia, inflammation, angiogenesis, oxidative stress, and metabolism were investigated. Mild and severe CIH increased insulin levels and induced whole-body insulin resistance in control animals, effects not associated with weight gain. In control animals, CIH did not modify adipocytes perimeter as well as adipose tissue hypoxia, angiogenesis, inflammation or oxidative stress. In HF animals, severe CIH attenuated the increase in adipocytes perimeter, adipose tissue hypoxia, angiogenesis, and dysmetabolism. In conclusion, adipose tissue dysfunction is not the main trigger for initial dysmetabolism in CIH. CIH in an early stage might have a protective role against the deleterious effects of HF diet on adipose tissue metabolism.pt
dc.language.isoengpt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectObstructive sleep apneapt
dc.subjectMetabolic dysfunctionpt
dc.subjectInsulin resistancept
dc.subjectAdipose tissuept
dc.subjectHypoxiapt
dc.subjectInflammationpt
dc.subjectOxidative stresspt
dc.titleChronic Intermittent Hypoxia Induces Early-Stage Metabolic Dysfunction Independently of Adipose Tissue Deregulationpt
dc.typearticle-
degois.publication.firstPage1233pt
degois.publication.issue8pt
degois.publication.titleAntioxidantspt
dc.peerreviewedyespt
dc.identifier.doi10.3390/antiox10081233pt
degois.publication.volume10pt
dc.date.embargo2021-01-01*
uc.date.periodoEmbargo0pt
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-3422-290X-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
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This item is licensed under a Creative Commons License Creative Commons