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Título: | The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetes | Autor: | Guerra, Sara Isabel da Silva Gastaldelli, Amalia |
Data: | Dez-2020 | Editora: | Elsevier | Projeto: | Italian National Research Council (CNR) project MEDIFENCE (“MEtabolic DIseases, Food and ENvironment: from CElls to humans”) grant number DSB.AD003.061 Marie Skłodowska-Curie Grant Agreement No. 722619 Marie Skłodowska-Curie Grant Agreement No. 734719 |
Título da revista, periódico, livro ou evento: | Current Opinion in Pharmacology | Volume: | 55 | Resumo: | In this review we have discussed how the liver plays a central role in the regulation of glucose metabolism and in insulin clearance. Both non-alcoholic fatty liver disease (NAFLD) and diabetes (T2D) are characterized by high plasma insulin concentrations, hepatic insulin resistance, high hepatic glucose production (HGP), in particular gluconeogenesis (GNG), that are increased proportionally to fasting hyperglycemia, while postprandial hyperglycemia is due to impaired suppression of HGP by insulin, and reduced hepatic glycogen storage. The liver acts also as a modulator of peripheral insulin since most of insulin secreted by the pancreas is cleared by the liver during the first pass. Hepatokines and hepatic lipids can act in either autocrine or paracrine way and can be responsible of the changes in insulin sensitivity and alterations in glucose metabolism. | URI: | https://hdl.handle.net/10316/95086 | ISSN: | 14714892 | DOI: | 10.1016/j.coph.2020.10.016 | Direitos: | embargoedAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Guerra et al COPHAR-D-20-00084 R1 final.pdf | 1.06 MB | Adobe PDF | Ver/Abrir |
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