Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/95086
DC Field | Value | Language |
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dc.contributor.author | Guerra, Sara Isabel da Silva | - |
dc.contributor.author | Gastaldelli, Amalia | - |
dc.date.accessioned | 2021-06-21T12:24:53Z | - |
dc.date.available | 2021-06-21T12:24:53Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 14714892 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/95086 | - |
dc.description.abstract | In this review we have discussed how the liver plays a central role in the regulation of glucose metabolism and in insulin clearance. Both non-alcoholic fatty liver disease (NAFLD) and diabetes (T2D) are characterized by high plasma insulin concentrations, hepatic insulin resistance, high hepatic glucose production (HGP), in particular gluconeogenesis (GNG), that are increased proportionally to fasting hyperglycemia, while postprandial hyperglycemia is due to impaired suppression of HGP by insulin, and reduced hepatic glycogen storage. The liver acts also as a modulator of peripheral insulin since most of insulin secreted by the pancreas is cleared by the liver during the first pass. Hepatokines and hepatic lipids can act in either autocrine or paracrine way and can be responsible of the changes in insulin sensitivity and alterations in glucose metabolism. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier | pt |
dc.relation | Italian National Research Council (CNR) project MEDIFENCE (“MEtabolic DIseases, Food and ENvironment: from CElls to humans”) grant number DSB.AD003.061 | pt |
dc.relation | Marie Skłodowska-Curie Grant Agreement No. 722619 | pt |
dc.relation | Marie Skłodowska-Curie Grant Agreement No. 734719 | pt |
dc.rights | embargoedAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.title | The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetes | pt |
dc.type | article | - |
degois.publication.firstPage | 165-174 | pt |
degois.publication.lastPage | 174 | pt |
degois.publication.title | Current Opinion in Pharmacology | pt |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/abs/pii/S1471489220301193#! | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.coph.2020.10.016 | pt |
degois.publication.volume | 55 | pt |
dc.date.embargo | 2021-12-01 | * |
uc.date.periodoEmbargo | 365 | pt |
item.openairetype | article | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Guerra et al COPHAR-D-20-00084 R1 final.pdf | 1.06 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License