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https://hdl.handle.net/10316/93150
Título: | Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer's disease mouse model | Autor: | Ferreiro, Elisabete | Palavras-chave: | Alzheimer’s disease; Chronic hyperglycemia; Hippocampal neurogenesis; Immature neurons; Memory impairment; Synaptic facilitation; β-Catenin. | Data: | Ago-2020 | Título da revista, periódico, livro ou evento: | Neurobiology of Aging | Volume: | 92 | Resumo: | During aging, lifestyle-related factors shape the brain's response to insults and modulate the progression of neurodegenerative pathologies such as Alzheimer's disease (AD). This is the case for chronic hyperglycemia associated with type 2 diabetes, which reduces the brain's ability to handle the neurodegenerative burden associated with AD. However, the mechanisms behind the effects of chronic hyperglycemia in the context of AD are not fully understood. Here, we show that newly generated neurons in the hippocampal dentate gyrus of triple transgenic AD (3xTg-AD) mice present increased dendritic arborization and a number of synaptic puncta, which may constitute a compensatory mechanism allowing the animals to cope with a lower neurogenesis rate. Contrariwise, chronic hyperglycemia decreases the complexity and differentiation of 3xTg-AD newborn neurons and reduces the levels of β-catenin, a key intrinsic modulator of neuronal maturation. Moreover, synaptic facilitation is depressed in hyperglycemic 3xTg-AD mice, accompanying the defective hippocampal-dependent memory. Our data suggest that hyperglycemia evokes cellular and functional alterations that accelerate the onset of AD-related symptoms, namely memory impairment. | URI: | https://hdl.handle.net/10316/93150 | DOI: | 10.1016/j.neurobiolaging.2020.04.003 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Ferreiro et al_NeurobiologyAging-2020_repository.docx | Accepted Ms | 178 kB | Microsoft Word XML | Ver/Abrir |
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