Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/7956
Título: | Preparation and physicochemical characterization of omeprazole:methyl-beta-cyclodextrin inclusion complex in solid state | Autor: | Figueiras, Ana Ribeiro, Laura Vieira, M. Veiga, Francisco |
Data: | 2007 | Citação: | Journal of Inclusion Phenomena and Macrocyclic Chemistry. 57:1 (2007) 173-177 | Resumo: | Abstract In this work, we illustrate the usefulness of cyclodextrins, namely, methyl-ß-cyclodextrin (MßCD), an amorphous, methylated derivative of the natural ß-cyclodextrin (ßCD), as a tool to form an inclusion complex with omeprazole (OME), a poorly water soluble drug. Solid binary systems between OME and MßCD were prepared experimentally in a stoichiometry 1:1 by different techniques (physical mixing, kneading, spray-drying and freeze-drying). Afterward these products were characterized by Fourier transformation-infrared spectroscopy (FTIR); X-ray diffractometry (XRD) and scanning electron microscopy (SEM). The results obtained suggest that spray-drying and freeze-drying methods yield a higher degree of amorphous entities suggesting the formation of inclusion complexes between OME and MßCD. | URI: | https://hdl.handle.net/10316/7956 | DOI: | 10.1007/s10847-006-9200-4 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
Mostrar registo em formato completo
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.