Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/7956
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Figueiras, Ana | - |
dc.contributor.author | Ribeiro, Laura | - |
dc.contributor.author | Vieira, M. | - |
dc.contributor.author | Veiga, Francisco | - |
dc.date.accessioned | 2009-02-17T10:49:26Z | - |
dc.date.available | 2009-02-17T10:49:26Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Journal of Inclusion Phenomena and Macrocyclic Chemistry. 57:1 (2007) 173-177 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/7956 | - |
dc.description.abstract | Abstract In this work, we illustrate the usefulness of cyclodextrins, namely, methyl-ß-cyclodextrin (MßCD), an amorphous, methylated derivative of the natural ß-cyclodextrin (ßCD), as a tool to form an inclusion complex with omeprazole (OME), a poorly water soluble drug. Solid binary systems between OME and MßCD were prepared experimentally in a stoichiometry 1:1 by different techniques (physical mixing, kneading, spray-drying and freeze-drying). Afterward these products were characterized by Fourier transformation-infrared spectroscopy (FTIR); X-ray diffractometry (XRD) and scanning electron microscopy (SEM). The results obtained suggest that spray-drying and freeze-drying methods yield a higher degree of amorphous entities suggesting the formation of inclusion complexes between OME and MßCD. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Preparation and physicochemical characterization of omeprazole:methyl-beta-cyclodextrin inclusion complex in solid state | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1007/s10847-006-9200-4 | en_US |
uc.controloAutoridade | Sim | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.orcid | 0000-0001-8170-1113 | - |
crisitem.author.orcid | 0000-0002-3667-0562 | - |
crisitem.author.orcid | 0000-0002-1041-0068 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.