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Title: Indices of Metabolic Dysfunction and Oxidative Stress
Authors: Casadesus, Gemma 
Moreira, Paula 
Nunomura, Akihiko 
Siedlak, Sandra 
Bligh-Glover, William 
Balraj, Elizabeth 
Petot, Grace 
Smith, Mark 
Perry, George 
Issue Date: 2007
Citation: Neurochemical Research. 32:4 (2007) 717-722
Abstract: Abstract Metabolic alterations are a key player involved in the onset of Alzheimer disease pathophysiology and, in this review, we focus on diet, metabolic rate, and neuronal size differences that have all been shown to play etiological and pathological roles in Alzheimer disease. Specifically, one of the earliest manifestations of brain metabolic depression in these patients is a sustained high caloric intake meaning that general diet is an important factor to take in account. Moreover, atrophy in the vasculature and a reduced glucose transporter activity for the vessels is also a common feature in Alzheimer disease. Finally, the overall size of neurons is larger in cases of Alzheimer disease than that of age-matched controls and, in individuals with Alzheimer disease, neuronal size inversely correlates with disease duration and positively associates with oxidative stress. Overall, clarifying cellular and molecular manifestations involved in metabolic alterations may contribute to a better understanding of early Alzheimer disease pathophysiology.
DOI: 10.1007/s11064-007-9296-y
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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