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https://hdl.handle.net/10316/5168
Título: | Pyrrolidine-based amino alcohols: novel ligands for the enantioselective alkylation of benzaldehyde | Autor: | Gonsalves, António M. d'. A. Rocha Serra, M. Elisa S. Murtinho, Dina Silva, Vitor F. Beja, A. Matos Paixão, J. A. Silva, M. Ramos Veiga, L. Alte da |
Palavras-chave: | Enantioselective alkylation; [beta]-Amino alcohols; Diethylzinc; Pyrrolidinoalcohols; Benzaldehyde | Data: | 2003 | Citação: | Journal of Molecular Catalysis A: Chemical. 195:1-2 (2003) 1-9 | Resumo: | A series of easily obtained pyrrolidine-based [beta]-amino alcohols derived from tartaric acid and primary amines was synthesized and used as chiral ligands in the enantioselective alkylation of benzaldehyde. Using diethylzinc, 1-phenyl-1-propanol was obtained with enantiomeric excesses of up to 80% when (3S,4S)-N-(1-naphthylmethyl)-3,4-dihydroxypyrrolidine was used. The nature of the N-substituent on the ligand, as well as the reaction temperature proved to significantly influence reaction product distribution as well as the enantiomeric excess of the chiral alcohol. | URI: | https://hdl.handle.net/10316/5168 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Química - Artigos em Revistas Internacionais |
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file4be66d3480154457b85f68956d36d29f.pdf | 118.33 kB | Adobe PDF | Ver/Abrir |
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